Exploring host factors that impact reovirus replication, dissemination, and reovirus-induced cell death in cancer versus normal cells in culture

Methods in Molecular Biology

Volumn 797, Issue , 2012, Pages 163-176

  Shmulevitz, Maya ^a   Lee, Patrick W K ^b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Apoptosis; Cell to cell spread; Immunohistochemistry; MAPK ERK; Oncolytic virus; Plaque titration; Ras; Reovirus

Indexed keywords

ONCOLYTIC VIRUS; RAS PROTEIN;

APOPTOSIS; ARTICLE; CELL TRANSFORMATION; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; METHODOLOGY; NEOPLASM; ONCOLYTIC VIROTHERAPY; PHYSIOLOGY; REOVIRUS; SIGNAL TRANSDUCTION; TUMOR CELL LINE; VIRUS REPLICATION;

APOPTOSIS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; MAP KINASE SIGNALING SYSTEM; NEOPLASMS; ONCOLYTIC VIROTHERAPY; ONCOLYTIC VIRUSES; RAS PROTEINS; REOVIRIDAE; VIRUS REPLICATION;

ORTHOREOVIRUS;

EID: 80555135980     PISSN: 10643745     EISSN: 19406029     Source Type: Book Series    
DOI: 10.1007/978-1-61779-340-0_12     Document Type: Chapter

References (12)

1. Coffey M.C., Strong J.E., Forsyth P.A., Lee P.W. (1998) Reovirus therapy of tumors with activated Ras pathway. Science 282: 1332–4.
2. Hirasawa K., Nishikawa S.G., Norman K.L., Alain T., Kossakowska A., Lee P.W. (2002) Oncolytic reovirus against ovarian and colon cancer. Cancer Res 62: 1696–701.
3. Norman K.L., Coffey M.C., Hirasawa K. et al. (2002) Reovirus oncolysis of human breast cancer. Hum Gene Ther 13: 641–52.
4. Strong J.E., Coffey M.C., Tang D., Sabinin P., Lee P.W. (1998) The molecular basis of viral oncolysis: usurpation of the Ras signaling pathway by reovirus. EMBO J 17: 3351–62.
5. Marcato P., Shmulevitz M., Pan D., Stoltz D., Lee P.W. (2007) Ras transformation mediates reovirus oncolysis by enhancing virus uncoating, particle infectivity, and apoptosis-dependent release. Mol Ther 15: 1522–30.
6. Borden E.C., Sen G.C., Uze G. et al. (2007) Interferons at age 50: past, current and future impact on biomedicine. Nat Rev Drug Discov 6: 975–90.
7. Shmulevitz M., Pan L.Z., Garant K., Pan D., Lee P.W. (2010) Oncogenic Ras promotes reovirus spread by suppressing IFN-beta production through negative regulation of RIG-I signaling. Cancer Res 70: 4912–21.
8. Mendez I.I., Hermann L.L., Hazelton P.R., Coombs K.M. (2000) A comparative analysis of freon substitutes in the purification of reovirus and calicivirus. J Virol Methods 90: 59–67.
9. Virgin H.W., Mann M.A., Fields B.N., Tyler K.L. (1991) Monoclonal antibodies to reovirus reveal structure/function relationships between capsid proteins and genetics of susceptibility to antibody action. J Virol 65: 6772–81.
10. Duncia J.V., Santella J.B., III, Higley C.A. et al. (1998) MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products. Bioorg Med Chem Lett 8: 2839–44.
11. Tyler K.L., Mann M.A., Fields B.N., Virgin H.W. (1993) Protective anti-reovirus monoclonal antibodies and their effects on viral pathogenesis. J Virol 67: 3446–53.
12. Virgin H.W., Bassel-Duby R., Fields B.N., Tyler K.L. (1988) Antibody protects against lethal infection with the neurally spreading reovirus type 3 (Dearing). J Virol 62: 4594–604.