Molecular signature induced by RNASET2, a tumor antagonizing gene, in ovarian cancer cells

Oncotarget

Volumn 2, Issue 6, 2011, Pages 477-484

  Acquati, Francesco ^a   Monti, Laura ^a   Lualdi, Marta ^a   Fabbri, Marco ^b   Sacco, Maria Grazia ^b   Gribaldo, Laura ^b   Taramelli, Roberto ^a  

^a UNIVERSITY OF INSUBRIA   (Italy)

^b JOINT RESEARCH CENTRE   (Italy)

Author keywords

Cancer microenvironment; RNases; Transcriptional profile

Indexed keywords

AMPHIREGULIN; CD146 ANTIGEN; NICOTINAMIDE METHYLTRANSFERASE; RIBONUCLEASE; RNASET2 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

AMPHIREGULIN GENE; ARTICLE; CANCER CELL CULTURE; CANCER EPIDEMIOLOGY; CANCER LOCALIZATION; CARBOXYPEPTIDASE A GENE; DERMOKINE GENE; DNA DAMAGE INDUCIBLE TRANSCRIPT 4 GENE; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIM AND CYSTEINE RICH DOMAIN 1 GENE; MELANOMA CELL ADHESION MOLECULE GENE; NICOTINAMIDE N METHYLTRANSFERASE GENE; ONCOGENE; OVARY CANCER; PLASMINOGEN ACTIVATOR KINASE GENE; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE H GENE; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNASET2 GENE; SENSITIVITY ANALYSIS; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE; ANIMAL; CARCINOMA; FEMALE; GENE EXPRESSION REGULATION; GENETICS; OVARY TUMOR; PATHOLOGY; PHYSIOLOGY; REVIEW; TUMOR CELL CULTURE; UPREGULATION; VALIDATION STUDY;

ANIMALS; CARCINOMA; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; OVARIAN NEOPLASMS; RIBONUCLEASES; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION; VALIDATION STUDIES AS TOPIC;

EID: 80555133409     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.274     Document Type: Article

References (42)

1. Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol. 2007;18:581-92.
2. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ. Cancer statistics 2008. CA Cancer J Clin. 2008;58:71-96.
3. Feeley KM, Wells M. Precursor lesions of ovarian epithelial malignancy. Histopathology. 2001;38:87-95.
4. Auersperg N, Maines-Bandiera SL, Dyck HG, Kruk PA. Characterization of cultured human ovarian surface epithelial cells: phenotypic plasticity and premalignant changes. Laboratory Investigation. 1994;71:510-8.
5. Mueller M, Fusenig N. Friends or foes-bipolar effects of the tumor stroma in cancer. Nature Rev Cancer. 2004;4:839-42.
6. Liotta L, Kohn E. The microenvironment of the tumor-host interface. Nature. 2001;411:375-9.
7. Klein G, Imreh S, Zabarovsky ER. Why do we not all die of cancer at an early age? Adv Cancer Res. 2007;98:1-16.
8. Luthala N, Parker R. T2 Family ribonucleases: ancient enzymes with diverse roles. Trends Biochem. Sci. 2010;35:253-9.
9. Acquati F, Bertilaccio S, Grimaldi A, Monti L, Cinquetti R, Bonetti P, Lualdi M, Vidalino L, Fabbri M, Sacco MG, Rooijen N, Campomenosi P, Vigetti D, Passi A, Riva C, Capella C, et al. Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase. Proc Natl Acad Sci U S A. 2011;108:1104-9
10. Thompson DM, Parker R. The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress in Saccharomyces cerevisiae. J Cell Biol. 2009;185:43-50
11. Huang DW, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nature Protocols. 2009;4:44-57
12. Imreh S, Klein G, Zabarovsky ER. Search for unknown tumor-antagonizing genes. Genes Chromosomes Cancer. 2003;38:307-21.
13. Klein G. Toward a genetics of cancer resistance. Proc Natl Acad Sci USA. 2009;106:859-63.
14. Kerzerho J, Adotevi O, Castelli FA, Dosset M, Bernardeau K, Szely N, Lang F, Tartour E, Maillere B. The angiogenic growth factor and biomarker midkine is a tumor-shared antigen. J Immunol. 2010;185:418-23.
15. Ota K, Fujimori H, Ueda M, Jono H, Shinriki S, Ota T, Sueyoshi T, Taura M, Taguma A, Kai H, Shinohara M, Ando Y. Midkine expression is correlated with an adverse prognosis and is down-regulated by p53 in oral squamous cell carcinoma. Int J Oncol. 2010;37:797-804.
16. Rice GE, Edgell TA, Autelitano DJ. Evaluation of midkine and anterior gradient 2 in a multimarker panel for the detection of ovarian cancer. J Exp Clin Cancer Res. 2010;29:62.
17. Baillo A., Giroux C., Ethier S.P. Knock-down of Amphiregulin Inhibits Cellular Invasion in Inflammatory Breast Cancer, Journal of Cellular Physiology, 2011 Feb 1. doi: 10.1002/jcp.22620. [Epub ahead of print]
18. Bles N, Di Pietrantonio L, Boeynaems JM, Communi D. ATP confers tumorigenic properties to dendritic cells by inducing amphiregulin secretion Blood. 2010;116:3219-26.
19. Lamber EP, Horwitz AA, Parvin JD. BRCA1 represses amphiregulin gene expression Cancer Res. 2010;70:996-1005.
20. Aldovini D, Demichelis F, Doglioni C, Di Vizio D, Galligioni E, Brugnara S, Zeni B Griso C, Pegoraro C, Zannoni M, Gariboldi M, Balladore E, Mezzanzanica D, Canevari S, Barbareschi M. M-cam expression as marker of poor prognosis in epithelial ovarian cancer, Int. J. Cancer. 2006;119:1920-6.
21. Chen W, Zhang HL, Jiang YG, Li JH, Liu BL, Sun MY. Inhibition of CD146 gene expression via RNA interference reduces in vitro perineural invasion on ACC-M cell. J Oral Pathol Med. 2009;38:198-205.
22. Zabouo G, Imbert AM, Jacquemier J, Finetti P, Moreau T, Esterni B, Birnbaum D, Bertucci F, Chabannon C. CD146 expression is associated with a poor prognosis in human breast tumors and with enhanced motility in breast cancer cell lines. Breast Cancer Research. 2009;11:1-14.
23. Sudol M. From Rous sarcoma virus to plasminogen activator, src oncogene and cancer management Oncogene. 2011 Mar 7. [Epub ahead of print].
24. Roessler M, Rollinger W, Palme S, Hagmann ML, Berndt P, Engel AM, Schneidinger B, Pfeffer M, Andres H, Karl J, Bodenmüller H, Rüschoff J, Henkel T, Rohr G, Rossol S, Rösch W, et al. Identification of nicotinamide N methyltransferase as a novel serum tumor marker for colorectal cancer Clin Cancer Res. 2005;11:6550-7.
25. Wu Y, Siadaty MS, Berens ME, Hampton GM, Theodorescu D. Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration. Oncogene. 2008;27:6679-89.
26. Leclerc EA, Gazeilles L, Serre G, Guerrin M, Jonca N. The ubiquitous dermokine delta activates rab5 function in the early endocytic pathway. PLoS One. 2011;6:e17816.
27. Xu Y, Josson S, Fang F, Oberley TD, ST Clair DK, Wan XS, Sun Y, Bakthavatchalu V, Muthuswamy A, St Clair WH. RelB enhances prostate cancer growth: implications for the role of the nuclear factor-kappaB alternative pathway in tumorigenicity Cancer Res. 2009;69:3267-71.
28. Burkly L, Hession C, Ogata L, Reilly C, Marconi LA, Olson D, Tizard R, Cate R, Lo D. Expression of relB is required for the development of thymic medulla and dendritic cells. Nature. 1995;373:531-6.
29. Clark GJ, Gunningham S, Troy A, Vuckovic S, Hart DN. Expression of the RelB transcription factor correlates with the activation of human dendritic cells. Immunology. 1999;98:189-96.
30. Bitton-Worms K, Pikarsky E, Aronheim A. The AP-1 repressor protein, JDP2, potentiates hepatocellular carcinoma in mice. Mol Cancer. 2010; 9:54-8.
31. Chang B, Liu G, Yang G, Mercado-Uribe I, Huang M, Liu J. REDD1 is required for RAS-mediated transformation of human ovarian epithelial cells. Cell cycle. 2009;8:780-6.
32. Tanco S, Zhang X, Morano C, Avilés FX, Lorenzo J, Fricker LD. Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing. J Biol Chem. 2010;285:18385-96.
33. Pasquali C, Curchod ML, Wälchli S, Espanel X, Guerrier M, Arigoni F, Strous G, Hooft van Huijsduijnen R. Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor. Mol Endocrinol. 2003;17:2228-39.
34. Sharp TV, Munoz F, Bourboulia D, Presneau N, Darai E, Wang HW, Cannon M, Butcher DN, Nicholson AG, Klein G, Imreh S, Boshoff C. LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription. Proc Natl Acad Sci USA 2004;101:16531-6.
35. Nakao M, Shichijo S, Imaizumi T, Inoue Y, Matsunaga K, Yamada A, Kikuchi M, Tsuda N, Ohta K, Takamori S, Yamana H, Fujita H, Itoh K. Identification of a gene coding for a new squamous cell carcinoma antigen recognized by the CTL. J Immunol. 2000;164:2565-74.
36. Sica A, Larghi P, Mancino A, Rubino L, Porta C, Totaro MG, Rimoldi M, Biswas SK, Allavena P, Mantovani A. Macrophage polarization in tumour progression. Semin Cancer Biol. 2008;18:349-55.
37. Mineva ND, Rothstein TL, Meyers JA, Lerner A, Sonenshein GE. CD40 ligand-mediated activation of the de novo RelB NF-kappaB synthesis pathway in transformed B cells promotes rescue from apoptosis. J Biol Chem. 2007;282:17475-85.
38. Maccarana M, Olander B, Malmström J, Tiedemann K, Aebersold R, Lindahl U, Li JP, Malmström A. Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2. J Biol Chem. 2006;281:11560-8.
39. Kalathas D, Triantaphyllidou IE, Mastronikolis NS, Goumas PD, Papadas TA, Tsiropoulos G, Vynios DH. The chondroitin/dermatan sulfate synthesizing and modifying enzymes in laryngeal cancer: expressional and epigenetic studies. Head Neck Oncol. 2010;2:27.
40. Ten Dam GB, Yamada S, Kobayashi F, Purushothaman A, Van De Westerlo EM, Bulten J, Malmström A, Sugahara K, Massuger LF, Van Kuppevelt TH. Dermatan sulfate domains defined by the novel antibody GD3A12, in normal tissues and ovarian adenocarcinomas. Histochem Cell Biol. 2009;132:117-27.
41. Frank D, Frauen R, Hanselmann C, Kuhn C, Will R, Gantenberg J, Füzesi L, Katus HA, Frey N. Lmcd1/Dyxin, a novel Z-disc associated LIM protein, mediates cardiac hypertrophy in vitro and in vivo. J Mol Cell Cardiol. 2010;49:673-82.
42. Latonen L, Järvinen PM, Laiho M. Cytoskeleton-interacting LIM-domain protein CRP1 suppresses cell proliferation and protects from stress-induced cell death. Exp Cell Res. 2008;314:738-47.