-
1
-
-
85013312416
-
Tumor angiogenesis: therapeutic implications
-
Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971;285:1182-6
-
(1971)
N. Engl. J. Med.
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
2
-
-
77957726685
-
Vascular targeting therapy: Potential benefit depends on tumor and host related effects
-
Horsman MR, Bohn AB, Busk M. Vascular targeting therapy: potential benefit depends on tumor and host related effects. Exp Oncol 2010;11:143-8
-
(2011)
Exp. Oncol.
, vol.11
, pp. 143-148
-
-
Horsman, M.R.1
Bohn, A.B.2
Busk, M.3
-
3
-
-
47949099628
-
Modes of resistance to anti-ngiogenic therapy
-
Bergers G, Hanahan D. Modes of resistance to anti-ngiogenic therapy. Nat Rev Cancer 2008;8:592-603
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 592-603
-
-
Bergers, G.1
Hanahan, D.2
-
4
-
-
0037106374
-
Mechanisms and future directions for angiogenesis-based cancer therapies
-
Scappaticci FA. Mechanisms and future directions for angiogenesis-based cancer therapies, J Clin Oncol. 2002;20:3906-27
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 3906-3927
-
-
Scappaticci, F.A.1
-
5
-
-
0029944122
-
Angiostatin induces and sustains dormancy of human primary tumors in mice
-
O'Reilly MS, Holmgren L, Chen C, Folkman J. Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat Med 1996;2:689-92
-
(1996)
Nat. Med.
, vol.2
, pp. 689-692
-
-
O'Reilly, M.S.1
Holmgren, L.2
Chen, C.3
Folkman, J.4
-
6
-
-
0035123201
-
Pharmacological aspects of targeting cancer gene therapy to endothelial cells
-
Sedlacek HH. Pharmacological aspects of targeting cancer gene therapy to endothelial cells. Crit Rev Oncol Hematol 2001;37:169-215
-
(2001)
Crit. Rev. Oncol. Hematol.
, vol.37
, pp. 169-215
-
-
Sedlacek, H.H.1
-
7
-
-
0032542528
-
Gene therapy strategies for tumor antiangiogenesis
-
Kong HL, Crystal RG. Gene therapy strategies for tumor antiangiogenesis. J Natl Cancer Inst 1998;90:273-86
-
(1998)
J. Natl. Cancer Inst.
, vol.90
, pp. 273-286
-
-
Kong, H.L.1
Crystal, R.G.2
-
8
-
-
33847247850
-
Anti-angiogenic gene therapy of cancer: Current status and future prospects
-
Persano L, Crescenzi M, Indraccolo S. Anti-angiogenic gene therapy of cancer: current status and future prospects. Mol Aspects Med 2007;28:87-114
-
(2007)
Mol. Aspects. Med.
, vol.28
, pp. 87-114
-
-
Persano, L.1
Crescenzi, M.2
Indraccolo, S.3
-
9
-
-
0038210219
-
Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: Phase II results of the Kuopio Angiogenesis Trial KAT
-
Hedman M, Hartikainen J, Syvanne M, et al. Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II results of the Kuopio Angiogenesis Trial (KAT).Circulation 2003;107:2677-83
-
(2003)
Circulation
, vol.107
, pp. 2677-2683
-
-
Hedman, M.1
Hartikainen, J.2
Syvanne, M.3
-
10
-
-
0036665610
-
Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: A randomized placebo-controlled double-blinded Phase II study
-
Makinen K, Manninen H, Hedman M, et al. Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: a randomized, placebo-controlled, double-blinded Phase II study. Mol Ther 2002;6:127-33
-
(2002)
Mol. Ther.
, vol.6
, pp. 127-133
-
-
Makinen, K.1
Manninen, H.2
Hedman, M.3
-
11
-
-
38949142281
-
Pharmacokinetic and pharmacodynamic study of intratumoral injection of an adenovirus encoding endostatin in patients with advanced tumors
-
Li HL, Li S, Shao JY, et al. Pharmacokinetic and pharmacodynamic study of intratumoral injection of an adenovirus encoding endostatin in patients with advanced tumors. Gene Ther 2008;15:247-56
-
(2008)
Gene. Ther.
, vol.15
, pp. 247-256
-
-
Li, H.L.1
Li, S.2
Shao, J.Y.3
-
12
-
-
19944379432
-
Clinical and local biological effects of an intratumoral injection of mda-7 IL24; INGN 241 in patients with advanced carcinoma: A Phase I study
-
Cunningham CC, Chada S, Merritt JA, et al. Clinical and local biological effects of an intratumoral injection of mda-7 (IL24; INGN 241) in patients with advanced carcinoma: a Phase I study. Mol Ther 2005;11:149-59
-
(2005)
Mol. Ther.
, vol.11
, pp. 149-159
-
-
Cunningham, C.C.1
Chada, S.2
Merritt, J.A.3
-
13
-
-
20344403777
-
Phase I study of the intratumoral administration of recombinant canarypox viruses expressing B7.1 and interleukin 12 in patients with metastatic melanoma
-
Triozzi PL, Allen KO, Carlisle RR, et al. Phase I study of the intratumoral administration of recombinant canarypox viruses expressing B7.1 and interleukin 12 in patients with metastatic melanoma. Clin Cancer Res 2005;11:4168-75
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 4168-4175
-
-
Triozzi, P.L.1
Allen, K.O.2
Carlisle, R.R.3
-
14
-
-
0028918281
-
Targeting gene expression to the vascular wall in transgenic mice using the murine preproendothelin-1 promoter
-
Harats D, Kurihara H, Belloni P, et al. Targeting gene expression to the vascular wall in transgenic mice using the murine preproendothelin-1 promoter. J Clin Invest 1995;95:1335-44
-
(1995)
J. Clin. Invest
, vol.95
, pp. 1335-1344
-
-
Harats, D.1
Kurihara, H.2
Belloni, P.3
-
15
-
-
11144354459
-
Transcription-controlled gene therapy against tumor angiogenesis
-
Greenberger S, Shaish A, Varda-Bloom N, et al. Transcription-controlled gene therapy against tumor angiogenesis. J Clin Invest 2004;113:1017-24
-
(2004)
J. Clin. Invest
, vol.113
, pp. 1017-1024
-
-
Greenberger, S.1
Shaish, A.2
Varda-Bloom, N.3
-
16
-
-
0028985261
-
Self-association of the death domains of the p55 tumor necrosis factor TNF receptor and Fas/ APO1 prompts signaling for TNF and Fas/APO1 effects
-
Boldin MP, Mett IL, Varfolomeev EE, et al. Self-association of the "death domains" of the p55 tumor necrosis factor (TNF) receptor and Fas/ APO1 prompts signaling for TNF and Fas/APO1 effects. J Biol Chem 1995;270:387-91
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 387-391
-
-
Boldin, M.P.1
Mett, I.L.2
Varfolomeev, E.E.3
-
17
-
-
0026509439
-
Transcriptional regulation of the endothelin-1 gene by TNF-alpha
-
Marsden PA, Brenner BM. Transcriptional regulation of the endothelin-1 gene by TNF-alpha. Am J Physiol 1992;262:C854-61
-
(1992)
Am. J. Physiol.
, vol.262
-
-
Marsden, P.A.1
Brenner, B.M.2
-
18
-
-
0034967245
-
Tissue-specific gene therapy directed to tumor angiogenesis
-
Varda-Bloom N, Shaish A, Gonen A, et al. Tissue-specific gene therapy directed to tumor angiogenesis. Gene Ther 2001;8:819-27
-
(2001)
Gene. Ther.
, vol.8
, pp. 819-827
-
-
Varda-Bloom, N.1
Shaish, A.2
Gonen, A.3
-
20
-
-
48249155476
-
Antiangiogenic systemic gene therapy combined with doxorubicin administration induced caspase 8 and 9-mediated apoptosis in endothelial cells and an anti-metastasis effect
-
Peled M, Shaish A, Greenberger S, et al. Antiangiogenic systemic gene therapy combined with doxorubicin administration induced caspase 8 and 9-mediated apoptosis in endothelial cells and an anti-metastasis effect. Cancer Gene Ther 2008;15:535-42
-
(2008)
Cancer Gene. Ther.
, vol.15
, pp. 535-542
-
-
Peled, M.1
Shaish, A.2
Greenberger, S.3
-
21
-
-
80555129984
-
VB-111 a novel anti-angiogenic vector and a promising treatment for metastatic cancer in combination with other anticancer drugs abstract 3283
-
April; Orlando Florida. Philadelphia PA: AACR
-
Breitbart E, Cohen YC, Bangio L. VB-111 a novel anti-angiogenic vector and a promising treatment for metastatic cancer in combination with other anticancer drugs. [abstract 3283]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 April 2-6; Orlando, Florida. Philadelphia (PA): AACR; 2011
-
(2011)
Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research
, vol.2-6
, pp. 2011
-
-
Breitbart, E.1
Cohen, Y.C.2
Bangio, L.3
-
22
-
-
80555151639
-
A novel anti-angiogenic vector with vascular disrupting activity as a promising treatment for metastatic cancer abstract 1369
-
Apr; Washington DC. Philadelphia PA: AACR
-
Breitbart E, Bangio L, Harats D, et al. A novel anti-angiogenic vector with vascular disrupting activity as a promising treatment for metastatic cancer. [abstract 1369]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; 2010
-
(2011)
Proceedings of the 101st Annual Meeting of the American Association for Cancer Research
, vol.17-21
, pp. 2010
-
-
Breitbart, E.1
Bangio, L.2
Harats, D.3
-
23
-
-
80555127853
-
A Phase I trial of VB-111 a tissue and condition specific vascular disruptive anti-angiogenic agent based on novel Vascular Targeting System VTS for treatment of patients with advanced metastatic cancer abstract 1361
-
Apr; Washington DC. Philadelphia PA: AACR
-
Triozzi P, Brenner A, Giles F, et al. A Phase I trial of VB-111, a tissue and condition specific vascular disruptive anti-angiogenic agent, based on novel Vascular Targeting System, VTS, for treatment of patients with advanced metastatic cancer. [abstract 1361]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; 2010
-
(2011)
Proceedings of the 101st Annual Meeting of the American Association for Cancer Research
, vol.17-21
, pp. 2010
-
-
Triozzi, P.1
Brenner, A.2
Giles, F.3
-
24
-
-
84857992571
-
Safety and efficacy of VB-111 in subjects with advanced differentiated thyroid cancer
-
Vascular Biogenics Ltd operating as VBL therapeutics Available from
-
Vascular Biogenics Ltd operating as VBL therapeutics. Safety and efficacy of VB-111 in subjects with advanced differentiated thyroid cancer. ClinicalTrials.gov: NCT01229865 Available from: http://clinicaltrials.gov/ct2/ show/NCT01229865? term=NCT01229865&rank=1
-
ClinicalTrials.gov: NCT01229865
-
-
-
25
-
-
84857992572
-
Single-arm open-label multicenter study of VB-111 in patients with recurrent glioblastoma multiforme
-
Vascular Biogenics Ltd operating as VBL therapeutics Available from
-
Vascular Biogenics Ltd operating as VBL therapeutics. Single-arm open-label multicenter study of VB-111 in patients with recurrent glioblastoma multiforme. ClinicalTrials.gov: NCT01260506 Available from: http:// clinicaltrials.gov/ct2/show/NCT01260506? term=NCT01260506&rank=1
-
ClinicalTrials.Gov: NCT01260506
-
-
-
26
-
-
58149083885
-
Specific induction of tumor neovasculature death by modified murine PPE-1 promoter armed with HSV-TK
-
Varda-Bloom N, Hodish I, Shaish A, et al. Specific induction of tumor neovasculature death by modified murine PPE-1 promoter armed with HSV-TK. Pathobiology 2008;75:346-55
-
(2008)
Pathobiology
, vol.75
, pp. 346-355
-
-
Varda-Bloom, N.1
Hodish, I.2
Shaish, A.3
-
27
-
-
70350433821
-
Systemic administration of radiation-potentiated anti-angiogenic gene therapy against primary and metastatic cancer based on transcriptionally controlled HSV-TK
-
Hodish I, Tal R, Shaish A, et al. Systemic administration of radiation-potentiated anti-angiogenic gene therapy against primary and metastatic cancer based on transcriptionally controlled HSV-TK. Cancer Biol Ther 2009;8:424-32
-
(2009)
Cancer Biol. Ther.
, vol.8
, pp. 424-432
-
-
Hodish, I.1
Tal, R.2
Shaish, A.3
-
28
-
-
63449098636
-
Systemic administration of a conditionally replicating adenovirus targeted to angiogenesis reduced lung metastases burden in cotton rats
-
Peled M, Shaish A, Katav A, et al. Systemic administration of a conditionally replicating adenovirus, targeted to angiogenesis, reduced lung metastases burden in cotton rats. Clin Cancer Res 2009;15:1664-73
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 1664-1673
-
-
Peled, M.1
Shaish, A.2
Katav, A.3
-
29
-
-
33750717545
-
Vascular wall maturation and prolonged angiogenic effect by endothelial-specific plateletderived growth factor expression
-
Levanon K, Varda-Bloom N, Greenberger S, et al. Vascular wall maturation and prolonged angiogenic effect by endothelial-specific plateletderived growth factor expression. Pathobiology 2006;73:149-58
-
(2006)
Pathobiology
, vol.73
, pp. 149-158
-
-
Levanon, K.1
Varda-Bloom, N.2
Greenberger, S.3
-
30
-
-
56749096616
-
Endothelial-targeted gene transfer of hypoxia-inducible factor-1alpha augments ischemic neovascularization following systemic administration
-
Tal R, Shaish A, Rofe K, et al. Endothelial-targeted gene transfer of hypoxia-inducible factor-1alpha augments ischemic neovascularization following systemic administration. Mol Ther 2008;16:1927-36
-
(2008)
Mol. Ther.
, vol.16
, pp. 1927-1936
-
-
Tal, R.1
Shaish, A.2
Rofe, K.3
-
31
-
-
0034990761
-
Intravenous infusion of a replication-selective adenovirus ONYX-015 in cancer patients: Safety feasibility and biological activity
-
Nemunaitis J, Cunningham C, Buchanan A, et al. Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activity. Gene Ther 2001;8:746-59
-
(2001)
Gene. Ther.
, vol.8
, pp. 746-759
-
-
Nemunaitis, J.1
Cunningham, C.2
Buchanan, A.3
-
32
-
-
70349673595
-
A Phase I study of sunitinib plus bevacizumab in advanced solid tumors
-
Rini BI, Garcia JA, Cooney MM, et al. A Phase I study of sunitinib plus bevacizumab in advanced solid tumors. Clin Cancer Res 2009;15:6277-83
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 6277-6283
-
-
Rini, B.I.1
Garcia, J.A.2
Cooney, M.M.3
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