Design, synthesis, and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone antibacterial agents

Journal of Medicinal Chemistry

Volumn 54, Issue 21, 2011, Pages 7493-7502

  Xin, Qisheng ^a   Fan, Houxing ^a   Guo, Bin ^a   He, Huili ^a   Gao, Suo ^a   Wang, Hui ^b   Huang, Yanqin ^c   Yang, Yushe ^a  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

^c MicuRx Pharmaceuticals Inc   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOXAZINE DERIVATIVE; LINEZOLID; OXAZOLIDINONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; GRAM POSITIVE BACTERIUM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ACETAMIDES; ANIMALS; ANTI-BACTERIAL AGENTS; BENZOXAZINES; BIOLOGICAL AVAILABILITY; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; FEMALE; GRAM-POSITIVE BACTERIA; MALE; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; OXAZOLIDINONES; RATS; RATS, SPRAGUE-DAWLEY; STAPHYLOCOCCAL INFECTIONS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80455162617     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200614t     Document Type: Article

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