4-nitrobenzyloxycarbonyl derivatives of O 6-benzylguanine as hypoxia-activated prodrug inhibitors of O 6-alkylguanine-DNA alkyltransferase (AGT), which produces resistance to agents targeting the o -6 position of DNA guanine

Journal of Medicinal Chemistry

Volumn 54, Issue 21, 2011, Pages 7720-7728

  Zhu, Rui ^a   Liu, Mao Chin ^a   Luo, Mei Zhen ^a   Penketh, Philip G ^a   Baumann, Raymond P ^a   Shyam, Krishnamurthy ^a   Sartorelli, Alan C ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROBENZYL [6 (BENZYLOXY) 9H PURIN 2 YL]CARBAMATE; 4 NITROBENZYLOXYCARBONYL DERIVATIVE; 6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 6 O BENZYLGUANINE; CARBONYL DERIVATIVE; DIMETHYL SULFATE; GUANINE; LAROMUSTINE; PRODRUG; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CELL HYPOXIA; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; HUMAN; HUMAN TISSUE; PROSTATE CARCINOMA; PROTEIN EXPRESSION;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; CELL HYPOXIA; CELL LINE, TUMOR; DNA; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG SYNERGISM; GUANINE; HUMANS; HYDRAZINES; MICE; NADPH-FERRIHEMOPROTEIN REDUCTASE; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PRODRUGS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; XANTHINE OXIDASE;

EID: 80455162574     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201115f     Document Type: Article

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