-
1
-
-
80051580618
-
Cancer statistics 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths
-
Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J. Clin. 61, 212-236 (2011).
-
(2011)
CA Cancer J. Clin.
, vol.61
, pp. 212-236
-
-
Siegel, R.1
Ward, E.2
Brawley, O.3
Jemal, A.4
-
2
-
-
24944453855
-
Phase I trial of the oral antiangiogenesis agent AG 013736 in patients with advanced solid tumors: Pharmacokinetic and clinical results
-
Rugo HS, Herbst RS, Liu G et al. Phase I trial of the oral antiangiogenesis agent AG 013736 in patients with advanced solid tumors: pharmacokinetic and clinical results. J. Clin. Oncol. 23, 5474-5483 (2005).
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 5474-5483
-
-
Rugo, H.S.1
Herbst, R.S.2
Liu, G.3
-
3
-
-
75549086120
-
Effect of rifampin on the pharmacokinetics of axitinib AG 013736 in Japanese and caucasian healthy volunteers
-
Pithavala YK, Tortorici M, Toh M et al. Effect of rifampin on the pharmacokinetics of axitinib (AG 013736) in Japanese and Caucasian healthy volunteers. Cancer Chemother. Pharmacol. 65, 563-570 (2010).
-
(2010)
Cancer Chemother. Pharmacol.
, vol.65
, pp. 563-570
-
-
Pithavala, Y.K.1
Tortorici, M.2
Toh, M.3
-
4
-
-
84856533799
-
Effect of ketoconazole on the pharmacokinetics of axitinib in healthy volunteers
-
101007/s10637-010-9511-6 Epub ahead of print
-
Pithavala YK, Tong W, Mount J et al. Effect of ketoconazole on the pharmacokinetics of axitinib in healthy volunteers. Invest. New Drugs doi: 101007/s10637-010-9511-6 (2010) (Epub ahead of print).
-
(2010)
Invest. New Drugs
-
-
Pithavala, Y.K.1
Tong, W.2
Mount, J.3
-
5
-
-
58149337448
-
Nonclinical antiangiogenesis and antitumor activities of axitinib AG 013736 an oral potent and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1 2 3
-
Hu-Lowe DD, Zou HY, Grazzini ML et al. Nonclinical antiangiogenesis and antitumor activities of axitinib (AG 013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3 Clin. Cancer Res. 14, 7272-7283 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 7272-7283
-
-
Hu-Lowe, D.D.1
Zou, H.Y.2
Grazzini, M.L.3
-
6
-
-
24944515034
-
Dynamic contrast-enhanced magnetic resonance imaging as a pharmacodynamic measure of response after acute dosing of AG 013736 an oral angiogenesis inhibitor in patients with advanced solid tumors: Results from a Phase I study
-
Liu G, Rugo HS, Wilding G et al. Dynamic contrast-enhanced magnetic resonance imaging as a pharmacodynamic measure of response after acute dosing of AG 013736, an oral angiogenesis inhibitor, in patients with advanced solid tumors: results from a Phase I study. J. Clin. Oncol. 23, 5464-5473 (2005).
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 5464-5473
-
-
Liu, G.1
Rugo, H.S.2
Wilding, G.3
-
7
-
-
35448934762
-
Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: A phase II study
-
DOI 10.1016/S1470-2045(07)70285-1, PII S1470204507702851
-
Rixe O, Bukowski RM, Michaelson MD et al. Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a Phase II study. Lancet Oncol. 8, 975-984 (2007). (Pubitemid 47629888)
-
(2007)
Lancet Oncology
, vol.8
, Issue.11
, pp. 975-984
-
-
Rixe, O.1
Bukowski, R.M.2
Michaelson, M.D.3
Wilding, G.4
Hudes, G.R.5
Bolte, O.6
Motzer, R.J.7
Bycott, P.8
Liau, K.F.9
Freddo, J.10
Trask, P.C.11
Kim, S.12
Rini, B.I.13
-
8
-
-
70349388719
-
Phase II study of axitinib in sorafenib-refractory metastatic renal cell carcinoma
-
Rini BI, Wilding G, Hudes G et al. Phase II study of axitinib in sorafenib-refractory metastatic renal cell carcinoma. J. Clin. Oncol. 27, 4462-4468 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 4462-4468
-
-
Rini, B.I.1
Wilding, G.2
Hudes, G.3
-
9
-
-
80052225008
-
Axitinib versus sorafenib as second-line therapy for metastatic renal cell carcinoma mRCC: Results of Phase III AXIS trial
-
Chicago IL USA 4-8 June 2011
-
Rini BI, Escudier B, Tomczak P et al. Axitinib versus sorafenib as second-line therapy for metastatic renal cell carcinoma (mRCC): results of Phase III AXIS trial. Presented at: 47th ASCO Annual Meeting (2011).Chicago, IL, USA, 4-8 June 2011
-
(2011)
Presented at: 47th ASCO Annual Meeting
-
-
Rini, B.I.1
Escudier, B.2
Tomczak, P.3
-
10
-
-
33845313345
-
The clinical toxicity profile of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) targeting angiogenesis inhibitors; A review
-
DOI 10.1016/j.ejca.2006.09.015, PII S0959804906008483
-
Eskens FA, Verweij J. The clinical toxicity profile of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) targeting angiogenesis inhibitors; a review. Eur. J. Cancer 42, 3127-3139 (2006). (Pubitemid 44869016)
-
(2006)
European Journal of Cancer
, vol.42
, Issue.18
, pp. 3127-3139
-
-
Eskens, F.A.L.M.1
Verweij, J.2
-
11
-
-
63049093371
-
Phase I trial of bevacizumab plus escalated doses of sunitinib in patients with metastatic renal cell carcinoma
-
Feldman DR, Baum MS, Ginsberg MS et al. Phase I trial of bevacizumab plus escalated doses of sunitinib in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 27, 1432-1439 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 1432-1439
-
-
Feldman, D.R.1
Baum, M.S.2
Ginsberg, M.S.3
-
12
-
-
70349673595
-
A Phase I study of sunitinib plus bevacizumab in advanced solid tumors
-
Rini BI, Garcia JA, Cooney MM et al. A Phase I study of sunitinib plus bevacizumab in advanced solid tumors. Clin. Cancer Res. 15, 6277-6283 (2009).
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 6277-6283
-
-
Rini, B.I.1
Garcia, J.A.2
Cooney, M.M.3
-
13
-
-
48649107474
-
Efficacy of everolimus in advanced renal cell carcinoma: A double-blind randomised placebo-controlled Phase III trial
-
Motzer RJ, Escudier B, Oudard S et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled Phase III trial. Lancet 372, 449-456 (2008).
-
(2008)
Lancet
, vol.372
, pp. 449-456
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
-
14
-
-
13844254987
-
Gene expression analysis of renal carcinoma: Adipose differentiation- related protein as a potential diagnostic and prognostic biomarker for clear-cell renal carcinoma
-
DOI 10.1002/path.1693
-
Yao M, Tabuchi H, Nagashima Y et al. Gene expression analysis of renal carcinoma: adipose differentiation-related protein as a potential diagnostic and prognostic biomarker for clear-cell renal carcinoma. J. Pathol. 205, 377-387 (2005). (Pubitemid 40253927)
-
(2005)
Journal of Pathology
, vol.205
, Issue.3
, pp. 377-387
-
-
Yao, M.1
Tabuchi, H.2
Nagashima, Y.3
Baba, M.4
Nakaigawa, N.5
Ishiguro, H.6
Hamada, K.7
Inayama, Y.8
Kishida, T.9
Hattori, K.10
Yamada-Okabe, H.11
Kubota, Y.12
-
15
-
-
77952238828
-
Molecular stratification of clear cell renal cell carcinoma by consensus clustering reveals distinct subtypes and survival patterns
-
Brannon AR, Reddy A, Seiler M et al. Molecular stratification of clear cell renal cell carcinoma by consensus clustering reveals distinct subtypes and survival patterns. Genes Cancer 1, 152-163 (2010).
-
(2010)
Genes Cancer
, vol.1
, pp. 152-163
-
-
Brannon, A.R.1
Reddy, A.2
Seiler, M.3
-
16
-
-
56849096837
-
HIF a effects on c Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma
-
Gordan JD, Lal P, Dondeti VR et al. HIF a effects on c Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma. Cancer Cell 14, 435-446 (2008).
-
(2008)
Cancer Cell
, vol.14
, pp. 435-446
-
-
Gordan, J.D.1
Lal, P.2
Dondeti, V.R.3
-
17
-
-
79251635938
-
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
-
Varela I, Tarpey P, Raine K et al. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature 469, 539-542 (2011).
-
(2011)
Nature
, vol.469
, pp. 539-542
-
-
Varela, I.1
Tarpey, P.2
Raine, K.3
-
18
-
-
75149188170
-
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
-
Dalgliesh GL, Furge K, Greenman C et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 463, 360-363 (2010).
-
(2010)
Nature
, vol.463
, pp. 360-363
-
-
Dalgliesh, G.L.1
Furge, K.2
Greenman, C.3
-
19
-
-
12244301581
-
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
-
Mendel DB, Laird AD, Xin X et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin. Cancer Res. 9, 327-337 (2003). (Pubitemid 36109749)
-
(2003)
Clinical Cancer Research
, vol.9
, Issue.1
, pp. 327-337
-
-
Mendel, D.B.1
Douglas Laird, A.2
Xin, X.3
Louie, S.G.4
Christensen, J.G.5
Li, G.6
Schreck, R.E.7
Abrams, T.J.8
Ngai, T.J.9
Lee, L.B.10
Murray, L.J.11
Carver, J.12
Chan, E.13
Moss, K.G.14
Haznedar, J.O.15
Sukbuntherng, J.16
Blake, R.A.17
Sun, L.18
Tang, C.19
Miller, T.20
Shirazian, S.21
McMahon, G.22
Cherrington, J.M.23
more..
-
20
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
DOI 10.1158/0008-5472.CAN-04-1443
-
Wilhelm SM, Carter C, Tang L et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 64, 7099-7109 (2004). (Pubitemid 39331023)
-
(2004)
Cancer Research
, vol.64
, Issue.19
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
Wilkie, D.4
McNabola, A.5
Rong, H.6
Chen, C.7
Zhang, X.8
Vincent, P.9
McHugh, M.10
Cao, Y.11
Shujath, J.12
Gawlak, S.13
Eveleigh, D.14
Rowley, B.15
Liu, L.16
Adnane, L.17
Lynch, M.18
Auclair, D.19
Taylor, I.20
Gedrich, R.21
Voznesensky, A.22
Riedl, B.23
Post, L.E.24
Bollag, G.25
Trail, P.A.26
more..
-
21
-
-
49449117755
-
Discovery of 5-4-2 3-dimethyl-2H-indazol-6-yl methylamino-2-pyrimidinyl amino-2 m ethyl-benzenesulfonamide pazopanib a novel and potent vascular endothelial growth factor receptor inhibitor
-
Harris PA, Boloor A, Cheung M et al. Discovery of 5-[[4-[(2,3-dimethyl- 2H-indazol-6-yl)methylamino]-2-pyrimidinyl] amino]-2 m ethyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. J. Med. Chem. 51, 4632-4640 (2008).
-
(2008)
J. Med. Chem.
, vol.51
, pp. 4632-4640
-
-
Harris, P.A.1
Boloor, A.2
Cheung, M.3
-
22
-
-
33845882259
-
The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma
-
DOI 10.1073/pnas.0609329103
-
Podar K, Tonon G, Sattler M et al. The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma. Proc. Natl Acad. Sci. USA 103, 19478-19483 (2006). (Pubitemid 46026056)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.51
, pp. 19478-19483
-
-
Podar, K.1
Tonon, G.2
Sattler, M.3
Tai, Y.-T.4
LeGouill, S.5
Yasui, H.6
Ishitsuka, K.7
Kumar, S.8
Kumar, R.9
Pandite, L.N.10
Hideshima, T.11
Chauhan, D.12
Anderson, K.C.13
-
23
-
-
80455137975
-
Axitinib with or without dose titration as first-line therapy for metastatic renal cell carcinoma mRCC
-
Chicago IL USA 4-8 June 2010
-
Jonasch E, Bair A, Chen, Y, Rini BI. Axitinib with or without dose titration as first-line therapy for metastatic renal cell carcinoma (mRCC).Presented at: 46th ASCO Annual Meeting (2010).Chicago, IL, USA, 4-8 June 2010
-
(2010)
Presented at: 46th ASCO Annual Meeting
-
-
Jonasch, E.1
Bair, A.2
Chen, Y.3
Rini, B.I.4
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