Directed trans-differentiation of thymus cells into parathyroid-like cells without genetic manipulation

Tissue Engineering - Part C: Methods

Volumn 17, Issue 11, 2011, Pages 1051-1059

  Ignatoski, Kathleen M Woods ^a   Bingham, Evangeline L ^a   Frome, Lauren K ^a   Doherty, Gerard M ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEINS; MAMMALS; MEDICAL PROBLEMS; POLYMERASE CHAIN REACTION; STEM CELLS; TISSUE; TRANSCRIPTION; TRANSCRIPTION FACTORS;

AUTOIMMUNE DISEASE; AUTOLOGOUS CELL; CALCIUM CONCENTRATION; CALCIUM SENSING RECEPTORS; CHEMOKINE RECEPTORS; DIFFERENTIATED CELLS; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC MANIPULATIONS; HUMAN EMBRYONIC STEM CELLS; HUMAN TISSUES; IN-VITRO; ORGAN DEVELOPMENT; PARATHYROID HORMONES; PRECURSOR CELLS; REVERSE TRANSCRIPTION-POLYMERASE CHAIN REACTION; SONIC HEDGEHOGS;

CYTOLOGY;

ERINACEIDAE; MUS;

BIOLOGICAL MARKER; CALCIUM; PARATHYROID HORMONE;

ARTICLE; CELL ADHESION; CELL TRANSDIFFERENTIATION; CHILD; CYTOLOGY; DRUG EFFECT; ENDODERM; EPITHELIUM CELL; GENETIC ENGINEERING; HUMAN; METABOLISM; PARATHYROID GLAND; SECRETION; THYMUS;

BIOLOGICAL MARKERS; CALCIUM; CELL ADHESION; CELL TRANSDIFFERENTIATION; CHILD; ENDODERM; EPITHELIAL CELLS; GENETIC ENGINEERING; HUMANS; PARATHYROID GLANDS; PARATHYROID HORMONE; THYMUS GLAND;

EID: 80455129647     PISSN: 19373384     EISSN: 19373392     Source Type: Journal    
DOI: 10.1089/ten.tec.2011.0170     Document Type: Article

References (44)

1. Doherty, G.M., and Skogseid, B.M. Surgical Endocrinology. Philadelphia, PA: Lippincott, Williams and Wilkins, 2001.
2. Scott-Coombs, D., and Kinsman, R. Second National Audit Report. Parathyroid: Outcomes, 1st edition. Henley-on-Thames, Oxfordshire, UK: The British Association of Endocrine Surgeons, 2007, pp. 110-112.
3. Doherty, G.M. Complications of thyroid and parathyroid surgery. In: Mulholland, M.W., and Doherty, G.M., eds. Complications in Surgery. Philadelphia, PA: Lippincott, Williams and Wilkins, 2006, pp. 575-593.
4. Atiq, M., Joarder, A., Alam, M., Hossain, M., and Biswas, S. Analysis of post operative complications following total thyroidectomy. Mymensingh Med J 20, 238, 2011.
5. Roh, J., Kim, J., and Park, C. Central compartment re-operation for recurrent/persistent differentiated thyroid cancer: patterns of recurrence, morbidity, and prediction of postoperative hypocalcemia. Ann Surg Oncol 18, 1312, 2011.
6. Khan, M., Waguespack, S., and Hu, M. Medical management of postsurgical hypoparathyroidism. Endocr Pract 17, 18, 2011.
7. Youngwirth, L., Benavidez, J., Sippel, R., and Chen, H. Parathyroid hormone deficiency after total thyroidectomy: incidence and time. J Surg Res 163, 69, 2010.
8. Rubin, M., Dempster, D., Zhou, H., Shane, E., Nickolas, T., Sliney, J.J., et al. Dynamic and structural properties of the skeleton in hypoparathyroidism. J Bone Miner Res 23, 2018, 2008.
9. Claxton, A., Caramer, J., and Pierce, C. A systemic review of the associations between dose regimens and medication compliance. Clin Ther 23, 1296, 2001.
10. Bubalo, J., Clark, R., Jiing, S., Johnson, N., Miller, K., Clemens-Shipman, C., et al. Medication adherence: pharmacist perspective. J Am Pharm Assoc 50, 394, 2010.
11. DiMatteo, M., Haskard, K., and Williams, S. Health beliefs, disease severity, and patient adherence: a meta-analysis. Med Care 45, 521, 2007.
12. Martin, L., Williams, S., Haskard, K., and DiMatteo, M. The challenge of patient adherence. Ther Clin Risk Manage 1, 189, 2005.
13. Olson, J.A., Jr., DeBenedetti, M.K., Baumann, D.S., Wells, S.A., Jr. Parathyroid autotransplantation during thyroidec-tomy. Results of long-term follow-up. Ann Surg 223, 472; discussion 478-480, 1996.
14. Lo, C.Y. Parathyroid autotransplantation during thyroidec-tomy. ANZ J Surg 72, 902, 2002.
15. Wells, S.A., Jr., Gunnells, J.C., Shelburne, J.D., Schneider, A.B., and Sherwood, L.M. Transplantation of the parathyroid glands in man: clinical indications and results. Surgery 78, 34, 1975.
16. Bingham, E.L., Cheng, S-P, Ignatoski, K.M.W., and Doherty, G.M. Differentiation of hES cells to a parathyroid-like phe-notype. Stem cells Dev 18, 1071, 2009.
17. Woods Ignatoski, K., Bingham, E., Frome, L., and Doherty, G. Differentiaton of precursors into parathyroid-like cells for treatment of hypoparathyroidism. Surgery 148, 1186, 2010.
18. Mouiseddine, M., Mathieu, N., Stefani, J., Demarquay, C., and Bertho, J. Characterization and histological localization of multipotent mesenchymal stromal cells in the human postnatal thymus. Stem Cells Dev 17, 1165, 2008.
19. Cameron, R. Laboratory protocols for the immunotherapy of cancer. In: Rosenberg, S., ed. National Cancer Program, 1st edition. Fredricksburg, MD: Surgery Branch, National Cancer Institute, 1989, pp. 121-122.
20. Souberbielle, J., Cormier, C., Kinderman, C., Gao, P., Cantor, T., Forette, F., et al. Vitamin D staus and redefining serum parathyroid hormone reference range in the ederly. J Clin Endocrinol Metab 86, 3086, 2001.
21. Aloia, J., Feuerman, M., and Yeh, J. Reference range for serum parathyroid hormaone. Endocr Pract 12, 137, 2006.
22. Liu, Z., Farley, A., Chen, L., Kirby, B., Kovacs, C., Blackburn, C., et al. Thymus-associated parathyroid hormone has two cellular origins with distinct endocrine and immunological functions. PLoS Gen 6, 1, 2010.
23. Blackburn, C.C., and Manley, N.R. Developing a new paradigm for thymus organogenesis. Nature Rev Immunol 4, 278, 2004.
24. Blackburn, C.C., Manley, N.R., Palmer, D.B., Boyd, R.L., Anderson, G., and Ritter, M.A. One for all and all for one: thymic epithelial stem cells and regeneration. Trends Immunol 23, 391, 2002.
25. Carpenter, E.M., Goddard, J.M., Chisaka, O., Manley, N.R., and Capecchi, M.R. Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain. Development 118, 1063, 1993.
26. Goddard, J.M., Rossel, M., Manley, N.R., and Capecchi, M.R. Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve. Development 122, 3217, 1996.
27. Gordon, J., Bennett, A.R., Blackburn, C.C., and Manley, N.R. Gcm2 and Foxn1 mark early parathyroid-and thymus-specific domains in the developing third pharyngeal pouch. Mech Dev 103, 141, 2001.
28. Gordon, J., Wilson, V.A., Blair, N.F., Sheridan, J., Farley, A., Wilson, L., et al. Functional evidence for a single endodermal origin for the thymic epithelium. Nature Immunol 5, 546, 2004.
29. Gordon, J., Wilson, V.A., Moore-Scott, B.A., Manley, N.R., and Blackburn, C.C. In vivo and in vitro assays of thymic organogenesis. Methods Mol Med 105, 303, 2005.
30. Kovacs, C.S., Chafe, L.L., Fudge, N.J., Friel, J.K., and Manley, N.R. PTH regulates fetal blood calcium and skeletal mineralization independently of PTHrP. Endocrinology 142, 4983, 2001.
31. Kovacs, C.S., Manley, N.R., Moseley, J.M., Martin, T.J., and Kronenberg, H.M. Fetal parathyroids are not required to maintain placental calcium transport. J Clin Invest 107, 1007, 2001.
32. Liu, Z., Yu, S., and Manley, N.R. Gcm2 is required for the differentiation and survival of parathyroid precursor cells in the parathyroid/thymus primordia. Dev Biol 305, 333, 2007.
33. Manley, N.R. Thymus organogenesis and molecular mechanisms of thymic epithelial cell differentiation. Semin Immunol 12, 421, 2000.
34. Manley, N.R., Barrow, J.R., Zhang, T., and Capecchi, M.R. Hoxb2 and hoxb4 act together to specify ventral body wall formation. Dev Biol 237, 130, 2001.
35. Manley, N.R., and Blackburn, C.C. A developmental look at thymus organogenesis: where do the non-hematopoietic cells in the thymus come from? Curr Opin Immunol 15, 225, 2003.
36. Manley, N.R., and Capecchi, M.R. The role of Hoxa-3 in mouse thymus and thyroid development. Development 121, 1989, 1995.
37. Manley, N.R., and Capecchi, M.R. Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures. Dev Biol 192, 274, 1997.
38. Manley, N.R., and Capecchi, M.R. Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands. Dev Biol 195, 1, 1998.
39. Manley, N.R., O'Connell, M., Sun, W., Speck, N.A., and Hopkins, N. Two factors that bind to highly conserved sequences in mammalian type C retroviral enhancers. J Virol 67, 1967, 1993.
40. Manley, N.R., O'Connell, M.A., Sharp, P.A., and Hopkins, N. Nuclear factors that bind to the enhancer region of non-defective friend murine leukemia virus. J Virol 63, 4210, 1989.
41. Manley, N.R., Selleri, L., Brendolan, A., Gordon, J., and Cleary, M.L. Abnormalities of caudal pharyngeal pouch development in Pbx1 knockout mice mimic loss of Hox3 paralogs. Dev Biol 276, 301, 2004.
42. Moore-Scott, B.A., and Manley, N.R. Differential expression of Sonic hedgehog along the anterior-posterior axis regulates patterning of pharyngeal pouch endoderm and pharyngeal endoderm-derived organs. Dev Biol 278, 323, 2005.
43. D'Amour, K.A., Agulnick, A.D., Eliazer, S., Kelly, O.G., Kroon, E., and Baetge, E.E. Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol 23, 1534, 2005.
44. Bonfanti, P., Claudinot, S., Amici, A., Farley, A., Blackburn, C., and Barrandon, Y. Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells. Nature 466, 978, 2010.