Bivariate genome-wide association analyses of femoral neck bone geometry and appendicular lean mass

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Sun, Lu ^a   Tan, Li Jun ^a,b   Lei, Shu Feng ^a   Chen, Xiang Ding ^a   Li, Xi ^a   Pan, Rong ^a   Yin, Fang ^a   Liu, Quan Wei ^a   Yan, Xiao Feng ^a   Papasian, Christopher J ^c   Deng, Hong Wen ^a,b,c,d,e  

^a HUNAN NORMAL UNIVERSITY   (China)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

^d SHANGHAI UNIVERSITY   (China)

^e BEIJING JIAOTONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 873; MICRORNA 876; UNCLASSIFIED DRUG;

ADULT; ANTHROPOMETRIC PARAMETERS; ARTICLE; BUCKLING RATIO; CONTROLLED STUDY; CORTICAL THICKNESS; CROSS SECTIONAL AREA; FEMALE; FEMUR NECK; GENE; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; GENETIC ASSOCIATION; GENETIC CODE; GENETIC CORRELATION; GENETIC VARIABILITY; GENOME ANALYSIS; GEOMETRY; HEXOKINASE 2 GENE; HUMAN; LEAN BODY WEIGHT; MALE; PERIOSTEAL DIAMETER; PHENOTYPE; SECTION MODULUS; SINGLE NUCLEOTIDE POLYMORPHISM; UROMODULIN 2 GENE; ASIAN; BODY COMPOSITION; BODY MASS; BONE; GENETICS; HISTOLOGY; METHODOLOGY;

ASIAN CONTINENTAL ANCESTRY GROUP; BODY COMPOSITION; BODY MASS INDEX; BONE AND BONES; FEMALE; FEMUR NECK; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 80455126086     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027325     Document Type: Article

References (47)

1. Melton3rd LJ, (2003) Adverse outcomes of osteoporotic fractures in the general population. J Bone Miner Res 18: 1139-1141.
2. Peng Z, Tuukkanen J, Zhang H, Jamsa T, Vaananen HK, (1994) The mechanical strength of bone in different rat models of experimental osteoporosis. Bone 15: 523-532.
3. Pulkkinen P, Partanen J, Jalovaara P, Jamsa T, (2004) Combination of bone mineral density and upper femur geometry improves the prediction of hip fracture. Osteoporos Int 15: 274-280.
4. Handoll HH, Gillespie WJ, Gillespie LD, Madhok R, (2007) Moving towards evidence-based healthcare for musculoskeletal injuries: featuring the work of the Cochrane Bone, joint and Muscle Trauma Group. J R Soc Promot Health 127: 168-173.
5. Stone KL, Seeley DG, Lui LY, Cauley JA, Ensrud K, et al. (2003) BMD at multiple sites and risk of fracture of multiple types: long-term results from the Study of Osteoporotic Fractures. J Bone Miner Res 18: 1947-1954.
6. Ammann P, Rizzoli R, (2003) Bone strength and its determinants. Osteoporos Int 14 Suppl 3: S13-18.
7. Peacock M, Turner CH, Liu G, Manatunga AK, Timmerman L, et al. (1995) Better discrimination of hip fracture using bone density, geometry and architecture. Osteoporos Int 5: 167-173.
8. Crabtree N, Lunt M, Holt G, Kroger H, Burger H, et al. (2000) Hip geometry, bone mineral distribution, and bone strength in European men and women: the EPOS study. Bone 27: 151-159.
9. Crabtree NJ, Kroger H, Martin A, Pols HA, Lorenc R, et al. (2002) Improving risk assessment: hip geometry, bone mineral distribution and bone strength in hip fracture cases and controls. The EPOS study. European Prospective Osteoporosis Study. Osteoporos Int 13: 48-54.
10. Melton3rd LJ, Beck TJ, Amin S, Khosla S, Achenbach SJ, et al. (2005) Contributions of bone density and structure to fracture risk assessment in men and women. Osteoporos Int 16: 460-467.
11. Bethesda, (1995) Workshop on sarcopenia: muscle atrophy in old age. Proceedings. J Gerontol A Biol Sci Med Sci 50 Spec No: pp. 1-161.
12. Beck TJ, Oreskovic TL, Stone KL, Ruff CB, Ensrud K, et al. (2001) Structural adaptation to changing skeletal load in the progression toward hip fragility: the study of osteoporotic fractures. J Bone Miner Res 16: 1108-1119.
13. Wu S, Lei SF, Chen XD, Tan LJ, Jian WX, et al. (2007) The contributions of lean tissue mass and fat mass to bone geometric adaptation at the femoral neck in Chinese overweight adults. Ann Hum Biol 34: 344-353.
14. Ferretti JL, Cointry GR, Capozza RF, Frost HM, (2003) Bone mass, bone strength, muscle-bone interactions, osteopenias and osteoporoses. Mech Ageing Dev 124: 269-279.
15. Sun X, Lei SF, Deng FY, Wu S, Papacian C, et al. (2006) Genetic and environmental correlations between bone geometric parameters and body compositions. Calcif Tissue Int 79: 43-49.
16. Deng FY, Xiao P, Lei SF, Zhang L, Yang F, et al. (2007) Bivariate whole genome linkage analysis for femoral neck geometric parameters and total body lean mass. J Bone Miner Res 22: 808-816.
17. Liu YZ, Pei YF, Liu JF, Yang F, Guo Y, et al. (2009) Powerful bivariate genome-wide association analyses suggest the SOX6 gene influencing both obesity and osteoporosis phenotypes in males. PLoS One 4: e6827.
18. Heymsfield SB, Smith R, Aulet M, Bensen B, Lichtman S, et al. (1990) Appendicular skeletal muscle mass: measurement by dual-photon absorptiometry. Am J Clin Nutr 52: 214-218.
19. Kim J, Wang Z, Heymsfield SB, Baumgartner RN, Gallagher D, (2002) Total-body skeletal muscle mass: estimation by a new dual-energy X-ray absorptiometry method. Am J Clin Nutr 76: 378-383.
20. Marcora S, Casanova F, Williams E, Jones J, Elamanchi R, et al. (2006) Preliminary evidence for cachexia in patients with well-established ankylosing spondylitis. Rheumatology (Oxford) 45: 1385-1388.
21. Liu J, Pei Y, Papasian CJ, Deng HW, (2009) Bivariate association analyses for the mixture of continuous and binary traits with the use of extended generalized estimating equations. Genet Epidemiol 33: 217-227.
22. Chang PY, Jensen J, Printz RL, Granner DK, Ivy JL, et al. (1996) Overexpression of hexokinase II in transgenic mice. Evidence that increased phosphorylation augments muscle glucose uptake. J Biol Chem 271: 14834-14839.
23. Fueger PT, Heikkinen S, Bracy DP, Malabanan CM, Pencek RR, et al. (2003) Hexokinase II partial knockout impairs exercise-stimulated glucose uptake in oxidative muscles of mice. Am J Physiol Endocrinol Metab 285: E958-963.
24. Streffer C, (1994) Glucose-, energy-metabolism and cell proliferation in tumors. Adv Exp Med Biol 345: 327-333.
25. Liechty EA, Denne SC, Lemons JA, Kien CL, (1991) Effects of glucose infusion on leucine transamination and oxidation in the ovine fetus. Pediatr Res 30: 423-429.
26. Movcessian SG, Boghosian AA, Kamalian RG, Urganjian MK, (1972) Effect of Krebs cycle components and glucose on the deamination of mono- and dinucleotides in brain mitochondrial fractions. Vopr Biokhim Mozga 7: 11-17.
27. Vander Heiden MG, Plas DR, Rathmell JC, Fox CJ, Harris MH, et al. (2001) Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol Cell Biol 21: 5899-5912.
28. Leidy HJ, Carnell NS, Mattes RD, Campbell WW, (2007) Higher protein intake preserves lean mass and satiety with weight loss in pre-obese and obese women. Obesity (Silver Spring) 15: 421-429.
29. Balint E, Szabo P, Marshall CF, Sprague SM, (2001) Glucose-induced inhibition of in vitro bone mineralization. Bone 28: 21-28.
30. Braithwaite SS, Palazuk B, Colca JR, Edwards3rd CW, Hofmann C, (1995) Reduced expression of hexokinase II in insulin-resistant diabetes. Diabetes 44: 43-48.
31. Vestergaard H, Bjorbaek C, Hansen T, Larsen FS, Granner DK, et al. (1995) Impaired activity and gene expression of hexokinase II in muscle from non-insulin-dependent diabetes mellitus patients. J Clin Invest 96: 2639-2645.
32. Carvalho M, Mulinari RA, Nakagawa Y, (2002) Role of Tamm-Horsfall protein and uromodulin in calcium oxalate crystallization. Braz J Med Biol Res 35: 1165-1172.
33. Kemter E, Rathkolb B, Rozman J, Hans W, Schrewe A, et al. (2009) Novel missense mutation of uromodulin in mice causes renal dysfunction with alterations in urea handling, energy, and bone metabolism. Am J Physiol Renal Physiol 297: F1391-1398.
34. Goffart S, Franko A, Clemen CS, Wiesner RJ, (2006) Alpha-actinin 4 and BAT1 interaction with the cytochrome c promoter upon skeletal muscle differentiation. Curr Genet 49: 125-135.
35. Dansithong W, Paul S, Comai L, Reddy S, (2005) MBNL1 is the primary determinant of focus formation and aberrant insulin receptor splicing in DM1. J Biol Chem 280: 5773-5780.
36. Okamoto Y, Takashima H, Higuchi I, Matsuyama W, Suehara M, et al. (2006) Molecular mechanism of rigid spine with muscular dystrophy type 1 caused by novel mutations of selenoprotein N gene. Neurogenetics 7: 175-183.
37. Kim HJ, Minashima T, McCarthy EF, Winkles JA, Kirsch T, (2010) Progressive ankylosis protein (ANK) in osteoblasts and osteoclasts controls bone formation and bone remodeling. J Bone Miner Res 25: 1771-1783.
38. Howell GR, Shindo M, Murray S, Gridley T, Wilson LA, et al. (2007) Mutation of a ubiquitously expressed mouse transmembrane protein (Tapt1) causes specific skeletal homeotic transformations. Genetics 175: 699-707.
39. Izumi K, Takagi M, Parikh AS, Hahn A, Miskovsky SN, et al. (2010) Late manifestations of tricho-rhino-pharangeal syndrome in a patient: Expanded skeletal phenotype in adulthood. Am J Med Genet A 152A: 2115-2119.
40. Roldan JC, Jepsen S, Miller J, Freitag S, Rueger DC, et al. (2004) Bone formation in the presence of platelet-rich plasma vs. bone morphogenetic protein-7. Bone 34: 80-90.
41. Kochi Y, Suzuki A, Yamada R, Yamamoto K, (2009) Genetics of rheumatoid arthritis: underlying evidence of ethnic differences. J Autoimmun 32: 158-162.
42. Palmer CG, Martinez A, Fox M, Sininger Y, Grody WW, et al. (2008) Ethnic differences in parental perceptions of genetic testing for deaf infants. J Genet Couns 17: 129-138.
43. Zhao LJ, Liu XG, Liu YZ, Liu YJ, Papasian CJ, et al. (2010) Genome-wide association study for femoral neck bone geometry. J Bone Miner Res 25: 320-329.
44. Beck T, (2003) Measuring the structural strength of bones with dual-energy X-ray absorptiometry: principles, technical limitations, and future possibilities. Osteoporos Int 14 Suppl 5: S81-88.
45. Chen Y, Xiong DH, Guo YF, Pan F, Zhou Q, et al. (2010) Pathway-based genome-wide association analysis identified the importance of EphrinA-EphR pathway for femoral neck bone geometry. Bone 46: 129-136.
46. Zou F, Lee S, Knowles MR, Wright FA, (2010) Quantification of population structure using correlated SNPs by shrinkage principal components. Hum Hered 70: 9-22.
47. Fisher RA, (1948) Combining independent tests of significance. American Statistician 2: 30.