Effect of PPARγ inhibition during pregnancy on posterior cerebral artery function and structure

Frontiers in Physiology

Volumn 1 AUG, Issue , 2010, Pages

  Chan, Siu Lung ^a   Chapman, Abbie C ^a   Sweet, Julie G ^a   Gokina, Natalia I ^a   Cipolla, Marilyn J ^a  

^a UNIVERSITY OF VERMONT   (United States)

Author keywords

Peroxisome proliferator activated receptor ; Posterior cerebral arteries; Pregnancy; Vascular remodeling; Vasodilation

Indexed keywords

EID: 80355133089     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2010.00130     Document Type: Article

References (40)

1. Amburgey, O. A., Reeves, S. A., Bernstein, I. M., and Cipolla, M. J. (2009). Resistance artery adaptation to pregnancy counteracts the vasoconstricting influence of plasmafrom normal pregnant women. Reprod. Sci. 17, 29-39.
2. Baumbach, G. L., Dobrin, P. B., Hart, M. N., and Heistad, D. D. (1988). Mechanics of cerebral arterioles in hypertensive rats. Circ. Res. 62, 56-64.
3. Baumbach, G. L., Sigmund, C. D., and Faraci, F. M. (2003). Cerebral arteriolar structure in mice overexpressing human renin and angiotensinogen. Hypertension 41, 50-55.
4. Benkirane, K., Amiri, F., Diep, Q. N., El Mabrouk, M., and Schiffrin, E. L. (2006). PPAR-gamma inhibits ang II-induced cell growth via SHIP2 and 4E-BP1. Am. J. Physiol. Heart Circ. Physiol. 290, H390-H397.
5. Berger, J. P., Akiyama, T. E., and Meinke, P. T. (2005). PPARs: therapeutic targets for metabolic disease. Trends Pharmacol. Sci. 26, 244-251.
6. Beyer, A. M., Baumbach, G. L., Halabi, C. M., Modrick, M. L., Lynch, C. M., Gerhold, T. D., Ghoneim, S. M., de Lange, W. J., Keen, H. L., Tsai, Y. S., Maeda, N., Sigmund, C. D., and Faraci, F. M. (2008). Interference with PPARgamma signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling. Hypertension 51, 867-871.
7. Carlin, A., and Alfirevic, Z. (2008). Physiological changes of pregnancy and monitoring. Best Pract. Res. Clin. Obstet. Gynaecol. 22, 801-823.
8. Chan, S. L., and Baumbach, G. (2009). Nox2 deficiency prevents angiotensin II-induced hypertrophy and inward remodeling in cerebral arterioles. FASEB J. 23, 613.611.
9. Cipolla, M. J., Bishop, N., Vinke, R. S., and Godfrey, J. A. (2010). PPAR{gamma} activation prevents hypertensive remodeling of cerebral arteries and improves vascular function in female rats. Stroke 41, 1266-1270.
10. Cipolla, M. J., and Bullinger, L. (2008). Pregnancy decreases cerebrovascular resistance and increases blood-brain barrier permeability during acute hypertension: a role in eclampsia? Reprod. Sci. 15, 288A.
11. Cipolla, M. J., DeLance, N., and Vitullo, L. (2006). Pregnancy prevents hypertensive remodeling of cerebral arteries: a potential role in the development of eclampsia. Hypertension 47, 619-626.
12. Cipolla, M. J., Smith, J., Bishop, N., Bullinger, L. V., and Godfrey, J. A. (2008). Pregnancy reverses hypertensive remodeling of cerebral arteries. Hypertension 51, 1052-1057.
13. Cipolla, M. J., Smith, J., Kohlmeyer, M. M., and Godfrey, J. A. (2009). SKca and IKca channels, myogenic tone, and vasodilator responses in middle cerebral arteries and parenchymal arterioles: effect of ischemia and reperfusion. Stroke 40, 1451-1457.
14. Cipolla, M. J., Vitullo, L., and McKinnon, J. (2004). Cerebral artery reactivity changes during pregnancy and the postpartum period: a role in eclampsia? Am. J. Physiol. Heart Circ. Physiol. 286, H2127-H2132.
15. Clapp, J. F. 3rd, and Capeless, E. (1997). Cardiovascular function before, during, and after the first and subsequent pregnancies. Am. J. Cardiol. 80, 1469-1473.
16. Cox, B. E., Rosenfeld, C. R., Kalinyak, J. E., Magness, R. R., and Shaul, P. W. (1996). Tissue specific expression of vascular smooth muscle angiotensin II receptor subtypes during ovine pregnancy. Am. J. Physiol. 271, H212-H221.
17. Dupuis, F., Atkinson, J., Liminana, P., and Chillon, J. M. (2005). Comparative effects of the angiotensin II receptor blocker, telmisartan, and the angiotensin-converting enzyme inhibitor, ramipril, on cerebrovascular structure in spontaneously hypertensive rats. J. Hypertens. 23, 1061-1066.
18. Gordon, M. (2007). "Maternal physiology," in Obstetrics - Normal and Problem Pregnancies, eds S. N. Gabbe Jr and J. L. Simpson (New York: Churchill Liverstone), 55-84.
19. Griendling, K. K., Ushio-Fukai, M., Lassegue, B., and Alexander, R. W. (1997). Angiotensin II signaling in vascular smooth muscle. New concepts. Hypertension 29, 366-373.
20. Halabi, C. M., Beyer, A. M., de Lange, W. J., Keen, H. L., Baumbach, G. L., Faraci, F. M., and Sigmund, C. D. (2008). Interference with PPARgamma function in smooth muscle causes vascular dysfunction and hypertension. Cell Metab. 7, 215-226.
21. Hsueh, W. A., and Law, R. E. (2001). PPARgamma and atherosclerosis: effects on cell growth and movement. Arterioscler. Thromb. Vasc. Biol. 21, 1891-1895.
22. Johnson, P. C. (1989). The myogenic response in the microcirculation and its interaction with other control systems. J. Hypertens. Suppl. 7, S33-S39; discussion S40.
23. Learmont, J. G., Cockell, A. P., Knock, G. A., and Poston, L. (1996). Myogenic and flow-mediated responses in isolated mesenteric small arteries from pregnant and nonpregnant rats. Am. J. Obstet. Gynecol. 174, 1631-1636.
24. Leesnitzer, L. M., Parks, D. J., Bledsoe, R. K., Cobb, J. E., Collins, J. L., Consler, T. G., Davis, R. G., Hull-Ryde, E. A., Lenhard, J. M., Patel, L., Plunket, K. D., Shenk, J. L., Stimmel, J. B., Therapontos, C., Willson, T. M., and Blanchard, S. G. (2002). Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662. Biochemistry 41, 6640-6650.
25. Livak, K. J., and Schmittgen, T. D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta c(t)) method. Methods 25, 402-408.
26. Mackey, K., Meyer, M. C., Stirewalt, W. S., Starcher, B. C., and McLaughlin, M. K. (1992). Composition and mechanics of mesenteric resistance arteries from pregnant rats. Am. J. Physiol. 263, R2-R8.
27. Meredith, D., Panchatcharam, M., Miriyala, S., Tsai, Y. S., Morris, A. J., Maeda, N., Stouffer, G. A., and Smyth, S. S. (2009). Dominant-negative loss of PPARgamma function enhances smooth muscle cell proliferation, migration, and vascular remodeling. Arterioscler. Thromb. Vasc. Biol. 29, 465-471.
28. Palmer, S. K., Zamudio, S., Coffin, C., Parker, S., Stamm, E., and Moore, L. G. (1992). Quantitative estimation of human uterine artery blood flow and pelvic blood flow redistribution in pregnancy. Obstet. Gynecol. 80, 1000-1006.
29. Parent, A., Schiffrin, E. L., and St-Louis, J. (1990). Role of the endothelium in adrenergic responses of mesenteric artery rings of pregnant rats. Am. J. Obstet. Gynecol. 163, 229-234.
30. Pascoal, I. F., Lindheimer, M. D., Nalbantian-Brandt, C., and Umans, J. G. (1995). Contraction and endothelium-dependent relaxation in mesenteric microvessels from pregnant rats. Am. J. Physiol. 269, H1899-H1904.
31. Ralevic, V., and Burnstock, G. (1996). Mesenteric arterial function in the rat in pregnancy: role of sympathetic and sensory-motor perivascular nerves, endothelium, smooth muscle, nitric oxide and prostaglandins. Br. J. Pharmacol. 117, 1463-1470.
32. Robinson, E., and Grieve, D. J. (2009). Significance of peroxisome proliferator-activated receptors in the cardiovascular system in health and disease. Pharmacol. Ther. 122, 246-263.
33. Sigmund, C. D. (2010). Endothelial and vascular muscle PPARgamma in arterial pressure regulation: lessons from genetic interference and deficiency. Hypertension 55, 437-444.
34. Singh, S., and Bennett, R. G. (2010). Relaxin signaling activates peroxisome proliferator-activated receptor gamma. Mol. Cell Endocrinol. 315, 239-245.
35. Sivarajah, A., McDonald, M. C., and Thiemermann, C. (2005). The cardioprotective effects of preconditioning with endotoxin, but not ischemia, are abolished by a peroxisome proliferator-activated receptor-gamma antagonist. J. Pharmacol. Exp. Ther. 313, 896-901.
36. Takeda, K., Ichiki, T., Tokunou, T., Funakoshi, Y., Iino, N., Hirano, K., Kanaide, H., and Takeshita, A. (2000). Peroxisome proliferator-activated receptor gamma activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cells. Circulation 102, 1834-1839.
37. Waite, L. L., Louie, R. E., and Taylor, R. N. (2005). Circulating activators of peroxisome proliferator-activated receptors are reduced in preeclamptic pregnancy. J. Clin. Endocrinol. Metab. 90, 620-626.
38. Waite, L. L., Person, E. C., Zhou, Y., Lim, K. H., Scanlan, T. S., and Taylor, R. N. (2000). Placental peroxisome proliferator-activated receptor-gamma is up-regulated by pregnancy serum. J. Clin. Endocrinol. Metab. 85, 3808-3814.
39. Wieser, F., Waite, L., Depoix, C., and Taylor, R. N. (2008). PPAR action in human placental development and pregnancy and its complications. PPAR Res. 2008, 527048.
40. Williams, K. P., and Wilson, S. (1998). Variation in cerebral perfusion pressure with different hypertensive states in pregnancy. Am. J. Obstet. Gynecol. 179, 1200-1203.