Experimental metastasis and CTL adoptive transfer immunotherapy mouse model

Journal of Visualized Experiments

Volumn , Issue 45, 2010, Pages

  Zimmerman, Mary ^a   Hu, Xiaolin ^a   Liu, Kebin ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

CTL adoptive transfer; Immunology; Issue 45; Lung; Metastasis; Tumor Immunology

Indexed keywords

EID: 80355123018     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/2077     Document Type: Article

References (17)

1. Ryan, M.H., Bristol, J.A., McDuffie, E., Abrams, S.I. Regression of extensive pulmonary metastases in mice by adoptive transfer of antigen-specific CD8(+) CTL reactive against tumor cells expressing a naturally occurring rejection epitope. J Immunol 167(8):4286-92 (2001).
2. Caldwell, S.A., Ryan, M.H., McDuffie, E., Abrams, S.I. The Fas/Fas ligand pathway is important for optimal tumor regression in a mouse model of CTL adoptive immunotherapy of experimental CMS4 lung metastases. J Immunol 171(5):2402-12 (2003).
3. Liu, K., Caldwell, S.A., Greeneltch, K.M., Yang, D., Abrams, S.I. CTL Adoptive Immunotherapy Concurrently Mediates Tumor Regression and Tumor Escape. J Immunol 176(6):3374-82 (2006).
4. Yang, D., Stewart, T.J., Smith, K.K., Georgi, D., Abrams, S.I., Liu, K. Downregulation of IFN-gammaR in association with loss of Fas function is linked to tumor progression. International journal of cancer 122(2):350-62 (2008).
5. Pages, F., Berger, A., Camus, M., et al. Effector memory T cells, early metastasis, and survival in colorectal cancer. N Engl J Med 353(25):2654-66 (2005).
6. Galon, J., Costes, A., Sanchez-Cabo, F., et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313(5795):1960-4 (2006).
7. Strater, J., Hinz, U., Hasel, C., et al. Impaired CD95 expression predisposes for recurrence in curatively resected colon carcinoma: clinical evidence for immunoselection and CD95L mediated control of minimal residual disease. Gut 54(5):661-5 (2005).
8. Camus, M., Tosolini, M., Mlecnik, B., et al. Coordination of intratumoral immune reaction and human colorectal cancer recurrence. Cancer research 69(6):2685-93 (2009).
9. Dudley, M.E., Wunderlich, J.R., Yang, J.C., et al. Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma. J Clin Oncol 23(10):2346-57 (2005).
10. Srivastava, M.K., Sinha, P., Clements, V.K., Rodriguez, P., Ostrand-Rosenberg, S. Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine. Cancer research;70(1):68-77.
11. Nagaraj, S., Gabrilovich, D.I. Tumor escape mechanism governed by myeloid-derived suppressor cells. Cancer research 68(8):2561-3 (2008).
12. Nguyen, D.X., Bos, P.D., Massague, J. Metastasis: from dissemination to organ-specific colonization. Nature reviews 9(4):274-84 (2009).
13. Heijstek, M.W., Kranenburg, O., Borel Rinkes, I.H. Mouse models of colorectal cancer and liver metastases. Digestive surgery 22(1-2):16-25 (2005).
14. Yang, D., Ud Din, N., Browning, D.D., Abrams, S.I., Liu, K. Targeting lymphotoxin beta receptor with tumor-specific T lymphocytes for tumor regression. Clin Cancer Res 13(17):5202-10 (2007).
15. Yang, D., Thangaraju, M., Browning, D.D., et al. IFN Regulatory Factor 8 Mediates Apoptosis in Nonhemopoietic Tumor Cells via Regulation of Fas Expression. J Immunol 179(7):4775-82 (2007).
16. Yang, D., Thangaraju, M., Greeneltch, K., et al. Repression of IFN regulatory factor 8 by DNA methylation is a molecular determinant of apoptotic resistance and metastatic phenotype in metastatic tumor cells. Cancer research 67(7):3301-9 (2007).
17. Wexler, H. Accurate identification of experimental pulmonary metastases. Journal of the National Cancer Institute 36(4):641-5 (1966).