Focal uptake of 68Ga-DOTATOC in the pancreas: Pathological or physiological correlate in patients with neuroendocrine tumours?

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 38, Issue 11, 2011, Pages 2005-2013

  Al Ibraheem, Akram ^a,b   Bundschuh, Ralph Alexander ^a   Notni, Johannes ^a   Buck, Andreas ^a,c   Winter, Anna ^a   Wester, Hans Jürgen ^a   Schwaiger, Markus ^a   Scheidhauer, Klemens ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b KING HUSSEIN CANCER CENTER   (Jordan)

^c UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

68Ga DOTATOC; Head of pancreas; Liver; Neuroendocrine tumour; SUV

Indexed keywords

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID PHENYL TYROSINE OCTREOTIDE GA 68; CONTRAST MEDIUM; SOMATOSTATIN DERIVATIVE; UNCLASSIFIED DRUG; DIAGNOSTIC AGENT; DRUG DERIVATIVE; GA(III) DOTATOC; GA(III)-DOTATOC; OCTREOTIDE; ORGANOMETALLIC COMPOUND;

ABDOMINAL RADIOGRAPHY; ARTICLE; ARTIFACT REDUCTION; CANCER DIAGNOSIS; CANCER PATIENT; CANCER STAGING; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; HISTOLOGY; HORMONE TRANSPORT; HUMAN; IMAGE ANALYSIS; NEUROENDOCRINE TUMOR; POSITRON EMISSION TOMOGRAPHY; ADULT; AGED; COMPUTER ASSISTED DIAGNOSIS; FEMALE; LABORATORY DIAGNOSIS; MALE; METABOLISM; MIDDLE AGED; PANCREAS; PATHOLOGY; PHYSIOLOGY; SCINTISCANNING; TRANSPORT AT THE CELLULAR LEVEL;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL TRANSPORT; FALSE POSITIVE REACTIONS; FEMALE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MALE; MIDDLE AGED; NEUROENDOCRINE TUMORS; OCTREOTIDE; ORGANOMETALLIC COMPOUNDS; PANCREAS; POSITRON-EMISSION TOMOGRAPHY AND COMPUTED TOMOGRAPHY;

EID: 80255138228     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-011-1875-0     Document Type: Article

References (18)

1. C Boy TA Heusner TD Poeppel A Redmann-Bischof N Unger W Jentzen 2011 (68)Ga-DOTATOC PET/CT and somatostatin receptor (sst1-sst5) expression in normal human tissue: correlation of sst2 mRNA and SUV(max) Eur J Nucl Med Mol Imaging 38 1224 1236 10.1007/s00259-011-1760-x 21369945 10.1007/s00259-011-1760-x 1:CAS:528:DC%2BC3MXmvVais70%3D
2. ED Brandner A Wu H Chen D Heron S Kalnicki K Komanduri, et al. 2006 Abdominal organ motion measured using 4D CT Int J Radiat Oncol Biol Phys 65 2 554 560 16690437 10.1016/j.ijrobp.2005.12.042
3. I Buchmann M Henze S Engelbrecht M Eisenhut A Runz M Schäfer, et al. 2007 Comparison of 68Ga-DOTATOC PET and 111In-DTPAOC (Octreoscan) SPECT in patients with neuroendocrine tumours Eur J Nucl Med Mol Imaging 34 10 1617 1626 17520251 10.1007/s00259-007-0450-1 1:STN:280:DC%2BD2srmtlaisQ%3D%3D (Pubitemid 47476920)
4. RA Bundschuh A Martinez-Möller SI Ziegler M Schwaiger K Scheidhauer 2008 Misalignment in PET/CT: relevance for SUV and therapy management Nuklearmedizin 47 2 N14 N15 18589491 1:STN:280:DC%2BD1cvhvFalsw%3D%3D
5. M Gabriel C Decristoforo D Kendler G Dobrozemsky D Heute C Uprimny, et al. 2007 68Ga-DOTA-Tyr3-octreotide PET in neuroendocrine tumors: comparison with somatostatin receptor scintigraphy and CT J Nucl Med 48 508 518 17401086 10.2967/jnumed.106.035667 1:CAS:528:DC%2BD2sXhtVert7jF (Pubitemid 47571404)
6. GW Goerres E Kamel B Seifert C Burger A Buck TF Hany, et al. 2002 Accuracy of image coregistration of pulmonary lesions in patients with non-small cell lung cancer using an integrated PET/CT system J Nucl Med 43 11 1469 1475 12411550 (Pubitemid 35285872)
7. A Haug CJ Auernhammer B Wängler R Tiling G Schmidt B Göke 2009 Intraindividual comparison of 68Ga-DOTA-TATE and 18F-DOPA PET in patients with well-differentiated metastatic neuroendocrine tumours Eur J Nucl Med Mol Imaging 36 765 770 10.1007/s00259-008-1030-8 19137293 10.1007/s00259-008-1030-8 1:CAS:528:DC%2BD1MXkt1yms70%3D
8. K Hermann BJ Krause RA Bundschuh T Dechow M Schwaiger 2009 Monitoring response to therapeutic interventions in patients with cancer Semin Nucl Med 39 3 210 232 10.1053/j.semnuclmed.2008.12.001
9. M Hofmann H Maecke R Börner E Weckesser P Schöffski L Oei, et al. 2001 Biokinetics and imaging with the somatostatin receptor PET radioligand (68)Ga-DOTATOC: preliminary data Eur J Nucl Med 28 1751 1757 11734911 10.1007/s002590100639 1:CAS:528:DC%2BD3MXosFagurs%3D
10. S Koukouraki LG Strauss V Georgoulias M Eisenhut U Haberkorn A Dimitrakopoulou-Strauss 2006 Comparison of the pharmacokinetics of 68Ga-DOTATOC and [18F]FDG in patients with metastatic neuroendocrine tumours scheduled for 90Y-DOTATOC therapy Eur J Nucl Med Mol Imaging 33 10 1115 1122 16763820 10.1007/s00259-006-0110-x 1:CAS:528:DC%2BD28XhtVahurvJ Epub 2006 Jun 9 (Pubitemid 44484467)
11. J Kowalski M Henze J Schuhmacher HR Maecke M Hofmann U Haberkorn 2003 Evaluation of positron emission tomography imaging using [68Ga]-DOTA-D-Phe(1)- Tyr(3)-octreotide in comparison to [111In]-DTPAOC SPECT. First results in patients with neuroendocrine tumors Mol Imaging Biol 5 42 48 14499161 10.1016/S1536-1632(03)00038-6 (Pubitemid 36596544)
12. U Kumar R Sasi S Suresh A Patel M Thangaraju P Metrakos, et al. 1999 Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis Diabetes 48 1 77 85 9892225 10.2337/diabetes.48.1.77 1:CAS:528:DyaK1MXhvV2qtA%3D%3D (Pubitemid 29019355)
13. G Meisetschläger T Poethko A Stahl I Wolf K Scheidhauer M Schottelius, et al. 2006 Gluc-Lys([18F]FP)-TOCA PET in patients with SSTR-positive tumors: biodistribution and diagnostic evaluation compared with [111In]DTPA-octreotide J Nucl Med 47 4 566 573 16595488 (Pubitemid 46768456)
14. IM Modlin KD Lye M Kidd 2003 A 5-decade analysis of 13,715 carcinoid tumors Cancer 97 4 934 950 12569593 10.1002/cncr.11105 (Pubitemid 36173145)
15. SA Nehmeh YE Erdi CC Ling KE Rosenzweig H Schoder SM Larson, et al. 2002 Effect of respiratory gating on quantifying PET images of lung cancer J Nucl Med 43 7 876 881 12097456 (Pubitemid 34747809)
16. JC Reubi B Waser JC Schaer JA Laissue 2001 Somatostatin receptor sst1-sst5 expression in normal and neoplastic human tissues using receptor autoradiography with subtype-selective ligands Eur J Nucl Med 28 7 836 846 11504080 10.1007/s002590100541 1:CAS:528:DC%2BD3MXkvVWltL0%3D (Pubitemid 32662546)
17. A Stahl G Meisetschläger M Schottelius K Bruus-Jensen I Wolf K Scheidhauer, et al. 2006 [123I]Mtr-TOCA, a radioiodinated and carbohydrated analogue of octreotide: scintigraphic comparison with [111In]octreotide Eur J Nucl Med Mol Imaging 33 1 45 52 16151771 10.1007/s00259-005-1872-2 1:CAS:528:DC%2BD2MXhtlSntrnO (Pubitemid 41785308)
18. Z Win A Al-Nahhas D Rubello MD Gross 2007 Somatostatin receptor PET imaging with gallium-68 labeled peptides Q J Nucl Med Mol Imaging 51 3 244 250 17464267 1:STN:280:DC%2BD2szmtlGisw%3D%3D (Pubitemid 47181084)