An ultra-pressure liquid chromatography-tandem mass spectrometry method for the simultaneous determination of three physalins in rat plasma and its application to pharmacokinetic study of Physalis alkekengi var. franchetii (Chinese lantern) in rats

Journal of Pharmaceutical and Biomedical Analysis

Volumn 58, Issue 1, 2012, Pages 94-101

  Zheng, Yunliang ^a   Chen, Yong ^a   Ren, Yiping ^b   Luan, Lianjun ^a   Wu, Yongjiang ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG PROVINCIAL CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

Pharmacokinetic; Physalins; Physalis alkekengi; Quantitative analysis; UPLC MS MS

Indexed keywords

4,7 DIDEHYDRONEOPHYSALIN B; ACETIC ACID ETHYL ESTER; PHYSALIN D; PHYSALIN G; PHYSALIN H; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; DRUG ISOLATION; DRUG STABILITY; DRUG STRUCTURE; ELECTROSPRAY; MALE; MAXIMUM PLASMA CONCENTRATION; MEDICINAL PLANT; NONHUMAN; PHYSALIS ALKEKENGI FRANCHETII; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION PROCESS;

ANIMALS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; MALE; PHYSALIS; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; SECOSTEROIDS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 80255138112     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.09.012     Document Type: Article

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