Ixodes scapularis salivary gland protein P11 facilitates migration of Anaplasma phagocytophilum from the tick gut to salivary glands

EMBO Reports

Volumn 12, Issue 11, 2011, Pages 1196-1203

  Liu, Lei ^a   Narasimhan, Sukanya ^a   Dai, Jianfeng ^a   Zhang, Lili ^a   Cheng, Gong ^a   Fikrig, Erol ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Anaplasma; haemocytes; Ixodes ticks; salivary gland protein

Indexed keywords

P11 PROTEIN; PEPTIDES AND PROTEINS; UNCLASSIFIED DRUG;

ANAPLASMA PHAGOCYTOPHILUM; ARTICLE; BACTERIAL MIGRATION; BACTERIAL PHENOMENA AND FUNCTIONS; BLOOD CELL; GENE SILENCING; IN VITRO STUDY; IN VIVO STUDY; INTESTINE; IXODES SCAPULARIS; MOUTH INFECTION; PRIORITY JOURNAL; PROTEIN BINDING; SALIVARY GLAND; SALIVARY GLAND DISEASE;

ANAPLASMA PHAGOCYTOPHILUM; ANIMALS; ANTIBODIES, PROTOZOAN; EHRLICHIOSIS; FEEDING BEHAVIOR; GASTROINTESTINAL TRACT; GENE EXPRESSION REGULATION; GENE SILENCING; HEMOCYTES; HEMOLYMPH; HUMANS; IXODES; MICE; MOVEMENT; PHAGOCYTOSIS; PROTEIN BINDING; PROTOZOAN PROTEINS; SALIVARY GLANDS; SALIVARY PROTEINS AND PEPTIDES;

ANAPLASMA; ANAPLASMA PHAGOCYTOPHILUM; IXODES; IXODES SCAPULARIS; IXODIDA; MUS; RICKETTSIALES;

EID: 80255137573     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2011.177     Document Type: Article

References (19)

1. Azad AF, Beard CB (1998) Rickettsial pathogens and their arthropod vectors. Emerg Infect Dis 4: 179-186 (Pubitemid 28311204)
2. Bakken JS, Dumler JS (2000) Human granulocytic ehrlichiosis. Clin Infect Dis 31: 554-560 (Pubitemid 32289590)
3. Bakken JS, Dumler JS, Chen SM, Eckman MR, Van Etta LL, Walker DH (1994) Human granulocytic ehrlichiosis in the upper Midwest United States. A new species emerging? JAMA 272: 212-218 (Pubitemid 24209083)
4. Borovickova B, Hypsa V (2005) Ontogeny of tick hemocytes: a comparative analysis of Ixodes ricinus and Ornithodoros moubata. Exp Appl Acarol 35: 317-333 (Pubitemid 40607914)
5. Carlyon JA, Fikrig E (2006) Mechanisms of evasion of neutrophil killing by Anaplasma phagocytophilum. Curr Opin Hematol 13: 28-33
6. Chen L, Wang K, Shao Y, Huang J, Li X, Shan J, Wu D, Zheng JJ (2008) Structural insight into the mechanisms of Wnt signaling antagonism by Dkk. J Biol Chem 283: 23364-23370
7. Elrod-Erickson M, Mishra S, Schneider D (2000) Interactions between the cellular and humoral immune responses in Drosophila. Curr Biol 10: 781-784 (Pubitemid 30466941)
8. Eslin P, Prevost G, Havard S, Doury G (2009) Immune resistance of Drosophila hosts against Asobara parasitoids: cellular aspects. Adv Parasitol 70: 189-215
9. Herron MJ, Nelson CM, Larson J, Snapp KR, Kansas GS, Goodman JL (2000) Intracellular parasitism by the human granulocytic ehrlichiosis bacterium through the P-selectin ligand, PSGL-1. Science 288: 1653-1656 (Pubitemid 30387433)
10. Hodzic E, Fish D, Maretzki CM, De Silva AM, Feng S, Barthold SW (1998) Acquisition and transmission of the agent of human granulocytic ehrlichiosis by Ixodes scapularis ticks. J Clin Microbiol 36: 3574-3578 (Pubitemid 28533231)
11. Kuhn KH, Haug T (1994) Ultrastructural, cytochemical, and immunocytochemical characterization of haemocytes of the hard tick Ixodes ricinus (Acari; Chelicerata). Cell Tissue Res 277: 493-504 (Pubitemid 24267515)
12. Kurtti TJ, Mattila JT, Herron MJ, Felsheim RF, Baldridge GD, Burkhardt NY, Blazar BR, Hackett PB, Meyer JM, Munderloh UG (2008) Transgene expression and silencing in a tick cell line: a model system for functional tick genomics. Insect Biochem Mol Biol 38: 963-968
13. Li L, Mao J, Sun L, Liu W, Wu D (2002) Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. J Biol Chem 277: 5977-5981 (Pubitemid 34968379)
14. Paulauskas A, Radzijevskaja J, Rosef O (2009) Anaplasma in ticks feeding on migrating birds and questing ticks in Lithuania and Norway. Clin Microbiol Infect 15(Suppl 2): 34-36
15. Rikihisa Y (2010) Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host cells. Nat Rev Microbiol 8: 328-339
16. Sukumaran B, Narasimhan S, Anderson JF, DePonte K, Marcantonio N, Krishnan MN, Fish D, Telford SR, Kantor FS, Fikrig E (2006) An Ixodes scapularis protein required for survival of Anaplasma phagocytophilum in tick salivary glands. J Exp Med 203: 1507-1517 (Pubitemid 43880327)
17. Sultana H, Neelakanta G, Kantor FS, Malawista SE, Fish D, Montgomery RR, Fikrig E (2010) Anaplasma phagocytophilum induces actin phosphorylation to selectively regulate gene transcription in Ixodes scapularis ticks. J Exp Med 207: 1727-1743
18. Zhan L et al (2010) Anaplasma phagocytophilum from rodents and sheep, China. Emerg Infect Dis 16: 764-768
19. Zorn AM (2001) Wnt signalling: antagonistic Dickkopfs. Curr Biol 11: R592-R595 (Pubitemid 32722559)