Mitochondrial cytochrome c synthase: CP motifs are not necessary for heme attachment to apocytochrome c

FEBS Letters

Volumn 585, Issue 21, 2011, Pages 3415-3419

  Moore, Rachel L ^a   Stevens, Julie M ^a   Ferguson, Stuart J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

CP motif; Cytochrome c; Heme lyase; Heme regulatory motif; Holocytochrome c synthase

Indexed keywords

BINDING PROTEIN; CYTOCHROME C; HEME; HOLOCYTOCHROME C SYNTHASE; MITOCHONDRIAL CYTOCHROME C SYNTHASE; SYNTHETASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOPLASM; ESCHERICHIA COLI; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN MOTIF; SACCHAROMYCES CEREVISIAE; ULTRAVIOLET SPECTROSCOPY; WESTERN BLOTTING;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CONSERVED SEQUENCE; CYTOCHROMES C; HEME; HUMANS; LYASES; MICE; MITOCHONDRIA; MITOCHONDRIAL DISEASES; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE;

ANIMALIA; ESCHERICHIA COLI; FUNGI; PROTOZOA; SACCHAROMYCES CEREVISIAE;

EID: 80255137459     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.08.042     Document Type: Article

References (21)

1. C. Sanders, S. Turkarslan, D.W. Lee, and F. Daldal Cytochrome c biogenesis: the Ccm system Trends Microbiol. 18 2010 266 274
2. P. Giege, J.M. Grienenberger, and G. Bonnard Cytochrome c biogenesis in mitochondria Mitochondrion 8 2008 61 73 (Pubitemid 350263736)
3. J.W. Allen, A.P. Jackson, D.J. Rigden, A.C. Willis, S.J. Ferguson, and M.L. Ginger Order within a mosaic distribution of mitochondrial c-type cytochrome biogenesis systems? FEBS J. 275 2008 2385 2402 (Pubitemid 351600078)
4. A. Mayer, W. Neupert, and R. Lill Translocation of apocytochrome c across the outer membrane of mitochondria J. Biol. Chem. 270 1995 12390 12397
5. M.E. Dumont, T.S. Cardillo, M.K. Hayes, and F. Sherman Role of cytochrome c heme lyase in mitochondrial import and accumulation of cytochrome c in Saccharomyces cerevisiae Mol. Cell. Biol. 11 1991 5487 5496 (Pubitemid 21895314)
6. H. Steiner, G. Kispal, A. Zollner, A. Haid, W. Neupert, and R. Lill Heme binding to a conserved Cys-Pro-Val motif is crucial for the catalytic function of mitochondrial heme lyases J. Biol. Chem. 271 1996 32605 32611 (Pubitemid 27008680)
7. K. Ogawa Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1 EMBO J. 20 2001 2835 2843 (Pubitemid 32938566)
8. J.T. Lathrop, and M.P. Timko Regulation by heme of mitochondrial protein transport through a conserved amino acid motif Science 259 1993 522 525 (Pubitemid 23058711)
9. L. Zhang, and L. Guarente Heme binds to a short sequence that serves a regulatory function in diverse proteins EMBO J. 14 1995 313 320
10. I. Wimplinger Mutations of the mitochondrial holocytochrome c-type synthase in X-linked dominant microphthalmia with linear skin defects syndrome Am. J. Hum. Genet. 79 2006 878 889 (Pubitemid 44763402)
11. P. Caroppi, F. Sinibaldi, L. Fiorucci, and R. Santucci Apoptosis and human diseases: mitochondrion damage and lethal role of released cytochrome C as proapoptotic protein Curr. Med. Chem. 16 2009 4058 4065
12. J.N. Rumbley, L. Hoang, and S.W. Englander Recombinant equine cytochrome c in Escherichia coli: high-level expression, characterization, and folding and assembly mutants Biochemistry 41 2002 13894 13901 (Pubitemid 35364863)
13. J.W. Allen, E.J. Tomlinson, L. Hong, and S.J. Ferguson The Escherichia coli cytochrome c maturation (Ccm) system does not detectably attach heme to single cysteine variants of an apocytochrome c J. Biol. Chem. 277 2002 33559 33563
14. C.F. Goodhew, K.R. Brown, and G.W. Pettigrew Haem staining in gels, a useful tool in the study of bacterial c-type cytochromes Biochim. Biophys. Acta 852 1986 288 294
15. I. Wimplinger, G.M. Shaw, and K. Kutsche HCCS loss-of-function missense mutation in a female with bilateral microphthalmia and sclerocornea: a novel gene for severe ocular malformations? Mol. Vis. 13 2007 1475 1482 (Pubitemid 47336810)
16. S. Hira, T. Tomita, T. Matsui, K. Igarashi, and M. Ikeda-Saito Bach1, a heme-dependent transcription factor, reveals presence of multiple heme binding sites with distinct coordination structure IUBMB Life 59 2007 542 551 (Pubitemid 47265848)
17. J.J. Chen, and I.M. London Regulation of protein synthesis by heme-regulated eIF-2 alpha kinase Trends Biochem. Sci. 20 1995 105 108
18. P. Hamel, V. Corvest, P. Giege, and G. Bonnard Biochemical requirements for the maturation of mitochondrial c-type cytochromes Biochim. Biophys. Acta 1793 2009 125 138
19. J.W.A. Allen Cytochrome c biogenesis in mitochondria - Systems III and V FEBS J. 2011 10.1111/j.1742-4658.2011.08231
20. J.G. Kleingardner, and K.L. Bren Comparing substrate specificity between cytochrome c maturation and cytochrome c heme lyase systems for cytochrome c biogenesis Metallomics 3 2011 396 403
21. J.M. Stevens, Y. Zhang, G. Muthuvel, K.A. Sam, J.W. Allen, and S.J. Ferguson The mitochondrial cytochrome c N-terminal region is critical for maturation by holocytochrome c synthase FEBS Lett. 585 2011 1891 1896