Synthesis and biological evaluation of novel pyrimidine derivatives as sub-micromolar affinity ligands of GalR2

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 23, 2011, Pages 7210-7215

  Sagi, Vasudeva Naidu ^a   Liu, Tianyu ^a   Lu, Xiaoying ^a   Bartfai, Tamas ^a   Roberts, Edward ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Binding affinities; G protein coupled receptor; Galanin; Seizure

Indexed keywords

2,4,6 TRIAMINOPYRIMIDINE; 4 BROMO N 2,N 6 DICYCLOHEXYLPYRIDINE 2,6 DIAMINE; GALANIN RECEPTOR 1; GALANIN RECEPTOR 2; N 2 (4 METHOXYPHENYL) 6 (PIPERIDIN 1 YL) N 4 (3 (TRIFLUOROMETHOXY)PHENYL)PYRIMIDINE 2,4 DIAMINE; N 2 (4 METHOXYPHENYL) 6 (PIPERIDIN 1 YL) N 4 (4 (TRIFLUOROMETHOXY)PHENE YL)PYRIMIDINE 2,4 DIAMINE; N 4 (3 (DIFLUOROMETHOXY)PHENYL) N 2 (4 METHOXYPHENYL) 6 (PIPERIDIN 1 YL)PYRIMIDINE 2,4 DIAMINE; N 4 (3 FLUORO 2 METHYLPHENYL) N 2 (4 METHOXYPHENYL) 6 (PIPERIDIN 1 YL)PYRIMIDINE 2,4 DIAMINE; N 4 (3 FLUORO 4 METHOXYPHENYL) N 2 (4 METHOXYPHENYL) 6 (PIPERIDIN 1YL)PYRIMIDINE 2,4 DIAMINE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; LIGAND BINDING; STRUCTURE ACTIVITY RELATION;

ANTICONVULSANTS; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; MOLECULAR STRUCTURE; PROTEIN BINDING; PYRIMIDINES; RECEPTOR, GALANIN, TYPE 2; SEIZURES;

EID: 80255136341     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.09.033     Document Type: Article

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