Silencing of the SNARE protein NAPA sensitizes cancer cells to cisplatin by inducing ERK1/2 signaling, synoviolin ubiquitination and p53 accumulation

Biochemical Pharmacology

Volumn 82, Issue 11, 2011, Pages 1630-1640

  Wu, Zchong Zcho ^a   Sun, Nian Kang ^a,b   Chien, Kun Yi ^a   Chao, Chuck C K ^a  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

Apoptosis; Chemotherapy; Cisplatin resistance; NAPA; Synoviolin

Indexed keywords

BINDING PROTEIN; CISPLATIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NSF ATTACHMENT PROTEIN ALPHA; PROTEIN P53; SNARE PROTEIN; SYNOVIOLIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; DRUG MECHANISM; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; HUMAN; HUMAN CELL; LUNG CARCINOMA; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; UBIQUITINATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CISPLATIN; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; HEK293 CELLS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; SIGNAL TRANSDUCTION; SOLUBLE N-ETHYLMALEIMIDE-SENSITIVE FACTOR ATTACHMENT PROTEINS; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 80255131442     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.08.018     Document Type: Article

References (44)

1. S.H. Kaufmanns Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etopside, camptothecin, and other cytotoxic anticancer drugs: a cautionary note Cancer Res 49 1989 5870 5878
2. S.W. Lowe, H.E. Ruley, T. Jacks, and D.E. Housman p53-dependent apoptosis modulates the cytotoxicity of anticancer agents Cell 74 1993 957 967 (Pubitemid 23289454)
3. P.A. Andrews, and S.B. Howell Cellular pharmacology of cisplatin: perspectives on mechanisms of acquired resistance Cancer Cells 2 1990 35 43 (Pubitemid 20218552)
4. G. Chu Cellular responses to cisplatin. The role of DNA-binding proteins and DNA repair J Biol Chem 269 1994 787 790
5. C.C. Chao Molecular basis of cis-diamminedicholoroplatinum(II) resistance: a review J Formosan Med Assoc 95 1996 893 900 (Pubitemid 27062125)
6. R.D. Baird, and S.B. Kaye Drug resistance reversal - are we getting closer? Eur J Cancer 39 2003 2450 2461 (Pubitemid 37340159)
7. K. Song, Z. Li, P. Seth, K.H. Cowan, and B.K. Sinha Sensitization of cis-platinum by a recombinant adenovirus vector expressing wild-type p53 gene in human ovarian carcinomas Oncol Res 9 1997 603 609 (Pubitemid 127787911)
8. W. Dempke, W. Voigt, A. Grothey, B.T. Hill, and H.J. Schmoll Cisplatin resistance and oncogenes - a review Anticancer Drugs 11 2000 225 236 (Pubitemid 30416950)
9. H. Niedner, R. Christen, X. Lin, A. Kondo, and S.B. Howell Identification of genes that mediate sensitivity to cisplatin Mol Pharmacol 60 2001 1153 1160 (Pubitemid 33144883)
10. Z.H. Siddik Cisplatin: mode of cytotoxic action and molecular basis of resistance Oncogene 22 2003 7265 7279 (Pubitemid 37487159)
11. D. Wang, and S.J. Lippard Cellular processing of platinum anticancer drugs Nat Rev Drug Discov 4 2005 307 320 (Pubitemid 41130944)
12. S. Yamasaki, N. Yagishita, T. Sasaki, M. Nakazawa, Y. Kato, and T. Yamadera Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin' EMBO J 26 2007 113 122 (Pubitemid 46094704)
13. L. Wang, G. He, P. Zhang, X. Wang, M. Jiang, and L. Yu Interplay between MDM2, MDMX Pirh2 and COP1: the negative regulators of p53 Mol Biol Rep 38 2011 229 236
14. K. Heminger, M. Markey, M. Mpagi, and S.J. Berberich Alterations in gene expression and sensitivity to genotoxic stress following HdmX or Hdm2 knockdown in human tumor cells harboring wild-type p53 Aging (Albany, NY) 1 2009 89 108
15. R. Koster, H. Timmer-Bosscha, R. Bischoff, J.A. Gietema, and S. de Jong Disruption of the MDM2-p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway Cell Death Dis 2 2011 e148
16. O. Baumann, and B. Walz Endoplasmic reticulum of animal cells and its organization into structural and functional domains Int Rev Cytol 205 2001 149 214 (Pubitemid 32390830)
17. G.K. Voeltz, M.M. Rolls, and T.A. Rapoport Structural organization of the endoplasmic reticulum EMBO Rep 3 2002 944 950 (Pubitemid 35256468)
18. D.G. Breckenridge, M. Germain, J.P. Mathai, M. Nguyen, and G.C. Shore Regulation of apoptosis by endoplasmic reticulum pathways Oncogene 22 2003 8608 8618 (Pubitemid 38019196)
19. T. Kuwana, and D.D. Newmeyer Bcl-2-family proteins and the role of mitochondria in apoptosis Curr Opin Cell Biol 15 2003 691 699 (Pubitemid 37487962)
20. M.J. Thomenius, and C.W. Distelhorst Bcl-2 on the endoplasmic reticulum: protecting the mitochondria from a distance J Cell Sci 116 2003 4493 4499 (Pubitemid 37461604)
21. J.M. Boyd, S. Malstrom, T. Subramanian, L.K. Venkatesh, U. Schaeper, and B. Elangovan Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins Cell 79 1994 341 351 (Pubitemid 24324923)
22. P. Bouillet, and A. Strasser BH3-only proteins - evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death J Cell Sci 115 2002 1567 1574 (Pubitemid 34520586)
23. T. Mund, A. Gewies, N. Schoenfeld, M.K. Bauer, and S. Grimm Spike, a novel BH3-only protein, regulates apoptosis at the endoplasmic reticulum FASEB J 17 2003 696 698
24. K. Nakajima, H. Hirose, TaniguchiM, H. Kurashina, K. Arasaki, and M. Nagahama Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion EMBO J 23 2004 3216 3226 (Pubitemid 39209146)
25. J. Bordallo, R.K. Plemper, A. Finger, and D.H. Wolf Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins Mol Biol Cell 9 1998 209 222 (Pubitemid 28065291)
26. R. Friedlander, E. Jarosch, J. Urban, C. Volkwein, and T. Sommer A regulatory link between ER-associated protein degradation and the unfolded-protein response Nat Cell Biol 2 2000 379 384
27. K.J. Travers, C.K. Patil, L. Wodicka, D.J. Lockhart, J.S. Weissman, and P. Walter Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation Cell 101 2000 249 258
28. B. Meusser, C. Hirsch, E. Jarosch, and T. Sommer ERAD: the long road to destruction Nat Cell Biol 7 2005 766 772 (Pubitemid 41079045)
29. S. Yamasaki, N. Yagishita, K. Nishioka, and T. Nakajima The roles of synoviolin in crosstalk between endoplasmic reticulum stress-induced apoptosis and p53 pathway Cell Cycle 6 2007 1319 1323 (Pubitemid 47327964)
30. A. Mandic, J. Hansson, S. Linder, and M.C. Shoshan Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling J Biol Chem 278 2003 9100 9106 (Pubitemid 36800390)
31. Z.Z. Wu, and C.C. Chao Knockdown of NAPA using short-hairpin RNA sensitizes cancer cells to cisplatin: implications to overcome chemoresistance Biochem Pharmacol 80 2010 827 837
32. Z.Z. Wu, H.P. Lu, and C.C. Chao Identification and functional analysis of genes which confer resistance to cisplatin in tumor cells Biochem Pharmacol 80 2010 262 276
33. C.L. Sun, and C.C. Chao Cross-resistance to death ligand-induced apoptosis in cisplatin-selected HeLa cells associated with overexpression of DDB2 and subsequent induction of cFLIP Mol Pharmacol 67 2005 1307 1314 (Pubitemid 40410431)
34. P. Kamarajan, N.K. Sun, C.L. Sun, and C.C. Chao Apaf1 overexpression partially overcomes apoptotic resistance in a cisplatin-selected HeLa cell line FEBS Lett 505 2001 206 212 (Pubitemid 32896667)
35. S.Y. Tsai, N.K. Sun, H.P. Lu, M.L. Cheng, and C.C. Chao Involvement of reactive oxygen species in multidrug resistance of a vincristine-selected lymphoblastoma Cancer Sci 98 2007 1106 1114
36. A.A. McCracken, and J.L. Brodsky Evolving questions and paradigm shifts in endoplasmic-reticulum-associated degradation (ERAD) Bioessays 25 2003 868 877 (Pubitemid 37081752)
37. Y. Aylon, and M. Oren Living with p53, dying of p53 Cell 130 2007 597 600 (Pubitemid 47268063)
38. K. Tsuruya, H. Yotsueda, H. Ikeda, M. Taniguchi, K. Masutani, and H. Hayashida Involvement of p53-transactivated Puma in cisplatin-induced renal tubular cell death Life Sci 83 2008 550 556
39. V.P. Guntur, J.C. Waldrep, J.J. Guo, K. Selting, and R. Dhand Increasing p53 protein sensitizes non-small cell lung cancer to paclitaxel and cisplatin in vitro Anticancer Res 30 2010 3557 3564
40. R.J. Barnard, A. Morgan, and R.D. Burgoyne Stimulation of NSF ATPase activity by alpha-SNAP is required for SNARE complex disassembly and exocytosis J Cell Biol 139 1997 875 883 (Pubitemid 27508558)
41. C. Ungermann, B.J. Nichols, H.R. Pelham, and W. Wickner A vacuolar v-t-SNARE complex, the predominant form in vivo and on isolated vacuoles, is disassembled and activated for docking and fusion J Cell Biol 140 1998 61 69 (Pubitemid 28070894)
42. J.T. Littleton, R.J. Barnard, S.A. Titus, J. Slind, E.R. Chapman, and B. Ganetzky SNARE-complex disassembly by NSF follows synaptic-vesicle fusion Proc Natl Acad Sci USA 98 2001 12233 12238 (Pubitemid 32959856)
43. J.G. Hanley, L. Khatri, P.I. Hanson, and E.B. Ziff NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex Neuron 34 2002 53 67 (Pubitemid 34270698)
44. C.Y. Lin, B.C. Tan, H. Liu, C.J. Shih, K.Y. Chien, and C.L. Lin Dephosphorylation of nucleophosmin by PP1β facilitates pRB binding and consequent E2F1-dependent DNA repair Mol Biol Cell 21 2010 4409 4417