Design and synthesis of pyridin-2-ylmethylaminopiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 23, 2011, Pages 6950-6954

  Skerlj, Renato ^a   Bridger, Gary ^a   Zhou, Yuanxi ^a   Bourque, Elyse ^a   McEachern, Ernest ^a   Langille, Jonathan ^a   Harwig, Curtis ^a   Veale, Duane ^a   Yang, Wen ^a   Li, Tongshong ^a   Zhu, Yongbao ^a   Bey, Michael ^a   Baird, Ian ^a   Sartori, Michael ^a   Metz, Markus ^a   Mosi, Renee ^a   Nelson, Kim ^a   Bodart, Veronique ^a   Wong, Rebecca ^a   Fricker, Simon ^a   Mac Farland, Ron ^a   Huskens, Dana ^b   Schols, Dominique ^b   more..

^a GENZYME CORPORATION   (United States)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

CCR5; Chemokine receptor; HIV 1; Schering C

Indexed keywords

CHEMOKINE RECEPTOR CCR5 ANTAGONIST; GLYCOPHORIN A; PYRIDIN 2 YLMETHYLAMINOPIPERIDIN 1 YLBUTYL AMIDE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CYTOTOXICITY; DOG; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PLASMA PROTEIN BINDING; RAT; VIRUS REPLICATION;

AMIDES; ANIMALS; ANTI-HIV AGENTS; DOGS; DRUG DESIGN; HIV-1; HUMANS; INHIBITORY CONCENTRATION 50; LEUKOCYTES, MONONUCLEAR; MOLECULAR STRUCTURE; PIPERIDINES; PYRIDINES; RATS; RECEPTORS, CCR5; VIRUS REPLICATION;

CANIS FAMILIARIS; HUMAN IMMUNODEFICIENCY VIRUS 1; RATTUS;

EID: 80255122746     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.09.133     Document Type: Article

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