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Volumn , Issue , 2010, Pages 3-22

The Three Rs

Author keywords

Animals in captivity, being dependent on man for their well being; Animals used for scientific purposes emotive and sensitive issues; High fidelity fallacy; Humane endpoints direct welfare cost minimisation of justifiable animal based research; Refinement, improving quality of life animals bred, kept for experimental purposes; Replacement strategies and systems; Scientific approach to animal welfare insights into ' what is meaningful to animals'; Scientific validation and regulatory acceptance; Three rs (3Rs) as part of mainstream science; Universities federation for animal welfare (UFAW) animals bred for experimental purposes

Indexed keywords


EID: 80155195034     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781444318777.ch2     Document Type: Chapter
Times cited : (14)

References (54)
  • 1
    • 0015591140 scopus 로고
    • An improved bacterial test system for the detection and classification of mutagens and carcinogens
    • Ames, B.N., Lee, F.D. and Durston, W.E. (1973) An improved bacterial test system for the detection and classification of mutagens and carcinogens. Proceedings of the National Academy of Sciences USA, 70, 782-786
    • (1973) Proceedings of the National Academy of Sciences USA , vol.70 , pp. 782-786
    • Ames, B.N.1    Lee, F.D.2    Durston W.E3
  • 2
    • 84887378327 scopus 로고
    • Anon, Editorial, 24 May 1839
    • Anon (1839) Editorial. London Medical Gazette, 24 May 1839, 212-215
    • (1839) London Medical Gazette , pp. 212-215
  • 3
    • 0035089414 scopus 로고    scopus 로고
    • 2000 Report of the American Veterinary Medical Association Panel on Euthanasia
    • AVMA
    • AVMA (2001) 2000 Report of the American Veterinary Medical Association Panel on Euthanasia. Journal of the American Veterinary Medical Association, 218, 669-696
    • (2001) Journal of the American Veterinary Medical Association , vol.218 , pp. 669-696
  • 4
    • 0029107457 scopus 로고
    • Practical aspects of the validation of toxicity test procedures. The report and recommendations of ECVAM workshop 5
    • Balls, M., Blaauboer, B.J., Fentem, J.H. et al. (1995) Practical aspects of the validation of toxicity test procedures. The report and recommendations of ECVAM workshop 5. Alternatives to Laboratory Animals, 23, 129-147
    • (1995) Alternatives to Laboratory Animals , vol.23 , pp. 129-147
    • Balls, M.1    Blaauboer, B.J.2    Fentem, J.H.3
  • 5
    • 33846918010 scopus 로고    scopus 로고
    • The principles of weight of evidence validation of test methods and test strategies
    • Balls, M., Amcof, P., Bremer, S. et al.. (2006) The principles of weight of evidence validation of test methods and test strategies. Alternatives to Laboratory Animals, 34, 603-620
    • (2006) Alternatives to Laboratory Animals , vol.34 , pp. 603-620
    • Balls, M.1    Amcof, P.2    Bremer, S.3
  • 6
    • 0001773464 scopus 로고    scopus 로고
    • Animal experimentation, the scientist and ethics
    • Barley, J.B. (1999) Animal experimentation, the scientist and ethics. Animal Technology, 50, 1-10
    • (1999) Animal Technology , vol.50 , pp. 1-10
    • Barley J.B1
  • 7
    • 17144406909 scopus 로고    scopus 로고
    • Potential for unintended consequences of environmental enrichment for laboratory animals and research results
    • Bayne, K. (2005) Potential for unintended consequences of environmental enrichment for laboratory animals and research results. Institute for Laboratory Animal Research Journal, 46, 129-139
    • (2005) Institute for Laboratory Animal Research Journal , vol.46 , pp. 129-139
    • Bayne, K.1
  • 8
    • 17144367707 scopus 로고    scopus 로고
    • Mandatory ' enriched'housing of laboratory animals: the need for evidence-based evaluation
    • Benefiel, A.C., Dong W.K. and Greenough, W.T. (2005) Mandatory ' enriched'housing of laboratory animals: the need for evidence-based evaluation. Institute of Laboratory Animal Research Journal, 46, 95-105
    • (2005) Institute of Laboratory Animal Research Journal , vol.46 , pp. 95-105
    • Benefiel, A.C.1    Dong, W.K.2    Greenough W.T3
  • 9
    • 0043235849 scopus 로고    scopus 로고
    • Bringing natural behaviors into the laboratory: a tribute to Paul MacLean
    • Blanchard, R.J. and Blanchard, D.C. (2003) Bringing natural behaviors into the laboratory: a tribute to Paul MacLean. Physiololgy & Behaviour, 79, 515-524
    • (2003) Physiololgy & Behaviour , vol.79 , pp. 515-524
    • Blanchard, R.J.1    Blanchard D.C2
  • 10
    • 0012143027 scopus 로고
    • Minimizing stress during physiological monitoring
    • Eds Niemi, S.M. and Willson, J.E., Scientists Center for Animal Welfare, Bethesda
    • Brockway, B.P., Hassler, C.R. and Hicks, N. (1993) Minimizing stress during physiological monitoring. In: Refinement and Reduction in Animal Testing. Eds Niemi, S.M. and Willson, J.E., pp. 569. Scientists Center for Animal Welfare, Bethesda
    • (1993) Refinement and Reduction in Animal Testing , pp. 569
    • Brockway, B.P.1    Hassler, C.R.2    Hicks, N.3
  • 11
    • 1942520531 scopus 로고
    • The contribution of environment to uniformity: variance control, refinement in pharmacology
    • Chance, M.R.A. (1957) The contribution of environment to uniformity: variance control, refinement in pharmacology. Laboratory Animals Bureau, Collected Papers, 6, 59-73
    • (1957) Laboratory Animals Bureau, Collected Papers , vol.6 , pp. 59-73
    • Chance M.R.A1
  • 12
    • 1542614820 scopus 로고    scopus 로고
    • The benefits of giving experimental animals the best possible environment
    • 8 th edn. Ed. Reinhardt, V, Animal Welfare Institute, Washington, DC
    • Chance, M.R.A. and Russell, W.M.S. (1997) The benefits of giving experimental animals the best possible environment. In: Comfortable Quarters for Laboratory Animals, 8 th edn. Ed. Reinhardt, V., pp. 12-14. Animal Welfare Institute, Washington, DC
    • (1997) Comfortable Quarters for Laboratory Animals , pp. 12-14
    • Chance, M.R.A.1    Russell W.M.S2
  • 13
    • 34347362982 scopus 로고    scopus 로고
    • Saliva specimen: a new laboratory tool for diagnostic and basic investigation
    • Chiappin, S., Antonelli, G., Gatti, R. et al.. (2007) Saliva specimen: a new laboratory tool for diagnostic and basic investigation. Clinica Chemica Acta, 383, 30-40
    • (2007) Clinica Chemica Acta , vol.383 , pp. 30-40
    • Chiappin, S.1    Antonelli, G.2    Gatti, R.3
  • 14
    • 0029824835 scopus 로고    scopus 로고
    • Recommendations for euthanasia of experimental animals: Part 1. DGXI of the European Commission
    • Close, B., Banister, K., Baumans, V. et al. (1996) Recommendations for euthanasia of experimental animals: Part 1. DGXI of the European Commission. Laboratory Animals, 30, 293-316
    • (1996) Laboratory Animals , vol.30 , pp. 293-316
    • Close, B.1    Banister, K.2    Baumans, V.3
  • 15
    • 18544393036 scopus 로고    scopus 로고
    • Recommendations for euthanasia of experimental animals: Part 2. DGXI of the European Commission
    • Close, B., Banister, K., Baumans, V. et al.. (1997) Recommendations for euthanasia of experimental animals: Part 2. DGXI of the European Commission. Laboratory Animals, 31, 1-32
    • (1997) Laboratory Animals , vol.31 , pp. 1-32
    • Close, B.1    Banister, K.2    Baumans, V.3
  • 17
    • 0035134037 scopus 로고    scopus 로고
    • A good practice guide to the administration of substances and removal of blood, including routes and volumes
    • European Federation of Pharmaceutical Industries Association and European Centre for the Validation of Alternative Methods
    • Diehl, K.H., Hull, R., Morton, D. et al.. (European Federation of Pharmaceutical Industries Association and European Centre for the Validation of Alternative Methods) (2001) A good practice guide to the administration of substances and removal of blood, including routes and volumes. Journal of Applied Toxicology, 21, 15-23
    • (2001) Journal of Applied Toxicology , vol.21 , pp. 15-23
    • Diehl, K.H.1    Hull, R.2    Morton, D.3
  • 18
    • 11244287990 scopus 로고    scopus 로고
    • Doing better animal experiments; together with notes on genetic nomenclature of laboratory animals
    • Insert
    • Festing, M. (2000) Doing better animal experiments; together with notes on genetic nomenclature of laboratory animals. ANZCCART News, 13, Insert
    • (2000) ANZCCART News , vol.13
    • Festing, M.1
  • 20
    • 0036374477 scopus 로고    scopus 로고
    • Guidelines for the design and statistical analysis of experiments using laboratory animals
    • Festing, M.F. & Altman, D.G. (2002) Guidelines for the design and statistical analysis of experiments using laboratory animals. Institute for Laboratory Animal Research Journal, 43, 244-258
    • (2002) Institute for Laboratory Animal Research Journal , vol.43 , pp. 244-258
    • Festing, M.F.1    Altman D.G2
  • 23
    • 1542790640 scopus 로고    scopus 로고
    • Assessing pain in animals-putting research into practice
    • Flecknell, P.A. and Roughan, J.V. (2004) Assessing pain in animals-putting research into practice. Animal Welfare, 13, S71-S75
    • (2004) Animal Welfare , vol.13
    • Flecknell, P.A.1    Roughan J.V2
  • 26
    • 0008396284 scopus 로고    scopus 로고
    • Cryopreservation and rederivation of embryos and gametes
    • Eds Jackson, I.J. and Abbott, C.M, Oxford University Press, Oxford
    • Glenister, P.H. and Rall, W.F. (2000) Cryopreservation and rederivation of embryos and gametes. In: Mouse Genetics and Transgenics-a Practical Approach. Eds Jackson, I.J. and Abbott, C.M., pp. 27-59. Oxford University Press, Oxford
    • (2000) Mouse Genetics and Transgenics-a Practical Approach , pp. 27-59
    • Glenister, P.H.1    Rall W.F2
  • 27
    • 0006628117 scopus 로고
    • On experiments in physiology as a question of medical ethics
    • Hall, M. (1847) On experiments in physiology as a question of medical ethics. The Lancet, 1847, 58-60
    • (1847) The Lancet , vol.1847 , pp. 58-60
    • Hall, M.1
  • 28
    • 19944430250 scopus 로고    scopus 로고
    • A modular approach to the ECVAM principles on test validity
    • Hartung, T., Bremer, S., Casati, S. et al.. (2004) A modular approach to the ECVAM principles on test validity. Alternatives to Laboratory Animals, 32, 467-472
    • (2004) Alternatives to Laboratory Animals , vol.32 , pp. 467-472
    • Hartung, T.1    Bremer, S.2    Casati, S.3
  • 29
    • 0005451355 scopus 로고    scopus 로고
    • Humane Endpoints in Animal Experimentation for Biomedical Research
    • 22-25 November 1998, Zeist, The Netherlands. The Royal Society of Medicine Press, London
    • Hendriksen, C.F.M. and Morton, D.B. (eds) (1999) Humane Endpoints in Animal Experimentation for Biomedical Research. In: Proceedings of the International Conference, 22-25 November 1998, Zeist, The Netherlands. The Royal Society of Medicine Press, London
    • (1999) Proceedings of the International Conference
    • Hendriksen, C.F.M.1    Morton, D.B.2
  • 30
    • 0034573475 scopus 로고    scopus 로고
    • Humane endpoints for animals used in biomedical research and testing refinement of vaccine potency testing with the use of humane endpoints.
    • Hendriksen, C.F.M. and Steen, B. (2000) Humane endpoints for animals used in biomedical research and testing refinement of vaccine potency testing with the use of humane endpoints. Institute for Laboratory Animal Research Journal V41 105-113
    • (2000) Institute for Laboratory Animal Research Journal , vol.V41 , pp. 105-113
    • Hendriksen, C.F.M.1    Steen, B.2
  • 34
    • 0003550440 scopus 로고    scopus 로고
    • Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM). NIH publication no. 01-4500.
    • Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) (2001) Guidance document on using in vitro data to estimate in vivo starting doses for acute toxicity. NIH publication no. 01-4500. http://iccvam.niehs.nih.gov/(accessed 24 November 2008)
    • (2001) Guidance document on using in vitro data to estimate in vivo starting doses for acute toxicity
  • 36
    • 0027353595 scopus 로고
    • Removal of blood from laboratory mammals and birds. First Report of the BVA/FRAME/RSPCA/UFAW Joint Working Group on Refinement
    • Joint Working Group on Refinement
    • Joint Working Group on Refinement (1993) Removal of blood from laboratory mammals and birds. First Report of the BVA/FRAME/RSPCA/UFAW Joint Working Group on Refinement. Laboratory Animals, 27, 1-22
    • (1993) Laboratory Animals , vol.27 , pp. 1-22
  • 37
    • 0024989675 scopus 로고
    • Identification of contact allergens using the murine local lymph node assay. Comparisons with the Buehler Occluded Patch Test in Guinea Pigs
    • Kimber, I., Hilton, J. and Botham, P.A. (1990) Identification of contact allergens using the murine local lymph node assay. Comparisons with the Buehler Occluded Patch Test in Guinea Pigs. Journal of Applied Toxicocology, 10, 173-180
    • (1990) Journal of Applied Toxicocology , vol.10 , pp. 173-180
    • Kimber, I.1    Hilton, J.2    Botham, P.A.3
  • 38
    • 33748774917 scopus 로고    scopus 로고
    • Using preference, motivation and aversion tests to ask specific questions about animals'feelings
    • Kirkden, R. and Pajor, E. (2006) Using preference, motivation and aversion tests to ask specific questions about animals'feelings. Applied Animal Behaviour, 100, 29-47
    • (2006) Applied Animal Behaviour , vol.100 , pp. 29-47
    • Kirkden, R.1    Pajor, E.2
  • 39
    • 0038387496 scopus 로고    scopus 로고
    • Evaluation and applications of radiotelemetry in small laboratory animals
    • Kramer, K. and Kinter, L. (2003) Evaluation and applications of radiotelemetry in small laboratory animals. Physiological Genomics, 13, 197-205
    • (2003) Physiological Genomics , vol.13 , pp. 197-205
    • Kramer, K.1    Kinter, L.2
  • 40
    • 0000631035 scopus 로고
    • The role of endotoxin in the extracellular coagulation of limulus blood
    • Levin, J. and Bang, F.B. (1964) The role of endotoxin in the extracellular coagulation of limulus blood. Bulletin of the Johns Hopkins Hospital, 115, 265-274
    • (1964) Bulletin of the Johns Hopkins Hospital , vol.115 , pp. 265-274
    • Levin, J.1    Bang F.B2
  • 42
    • 0030957691 scopus 로고    scopus 로고
    • Happy animals make good science
    • Poole, T. (1997) Happy animals make good science. Laboratory Animals, 31, 116-124
    • (1997) Laboratory Animals , vol.31 , pp. 116-124
    • Poole, T.1
  • 43
    • 0002962971 scopus 로고    scopus 로고
    • Criteria for humane endpoints
    • 22-25 November 1998, Zeist, The Netherlands. Eds Hendriksen, C.F.M. and Morton, D.B, Royal Society of Medicine Press, London
    • Richmond, J. (1999) Criteria for humane endpoints. In: Humane Endpoints in Animal Experiments for Biomedical Research: Proceedings of the International Conference, 22-25 November 1998, Zeist, The Netherlands. Eds Hendriksen, C.F.M. and Morton, D.B., pp. 26-32. Royal Society of Medicine Press, London
    • (1999) Humane Endpoints in Animal Experiments for Biomedical Research: Proceedings of the International Conference , pp. 26-32
    • Richmond, J.1
  • 44
    • 0034519691 scopus 로고    scopus 로고
    • The Three Rs: a journey or a destination?
    • Richmond, J. (2000) The Three Rs: a journey or a destination? Alternatives to Living Animals, 28, 761-773
    • (2000) Alternatives to Living Animals , vol.28 , pp. 761-773
    • Richmond, J.1
  • 45
    • 0034491145 scopus 로고    scopus 로고
    • Effects of surgery and analgesic administration on spontaneous behaviour in singly housed rats
    • Roughan, J.V. and Flecknell, P.A. (2000) Effects of surgery and analgesic administration on spontaneous behaviour in singly housed rats. Research in Veterinary Science, 69, 283-288
    • (2000) Research in Veterinary Science , vol.69 , pp. 283-288
    • Roughan, J.V.1    Flecknell P.A2
  • 47
    • 33646467664 scopus 로고    scopus 로고
    • Strategies to optimize the validity of disease models in the drug discovery process
    • Sams-Dodd, F. (2006) Strategies to optimize the validity of disease models in the drug discovery process. Drug Discovery Today, 11, 355-363
    • (2006) Drug Discovery Today , vol.11 , pp. 355-363
    • Sams-Dodd, F.1
  • 48
    • 0141740913 scopus 로고    scopus 로고
    • Training and remote monitoring of cardiovascular parameters in non-human primates
    • Schnell, C.R. and Gerber, P. (1997) Training and remote monitoring of cardiovascular parameters in non-human primates. Primate Report, 49, 61-70
    • (1997) Primate Report , vol.49 , pp. 61-70
    • Schnell, C.R.1    Gerber, P.2
  • 49
    • 0030787771 scopus 로고    scopus 로고
    • Elimination of abnormal toxicity test for sera and certain vaccines in the European Pharmacopoeia
    • Schwanig, M., Nagel, M., Duchow, K. and Kramer, B. (1997) Elimination of abnormal toxicity test for sera and certain vaccines in the European Pharmacopoeia. Vaccine, 15, 1047-1048
    • (1997) Vaccine , vol.15 , pp. 1047-1048
    • Schwanig, M.1    Nagel, M.2    Duchow, K.3    Kramer, B.4
  • 51
    • 0026612153 scopus 로고
    • The HID 50 (hypothermia-inducing dose 50): an alternative to the LD 50 for measurement of bacterial virulence
    • Soothill, J.S., Morton, D. and Ahmad, A. (1992) The HID 50 (hypothermia-inducing dose 50): an alternative to the LD 50 for measurement of bacterial virulence. International Journal of Experimental Pathology, 73, 95-98
    • (1992) International Journal of Experimental Pathology , vol.73 , pp. 95-98
    • Soothill, J.S.1    Morton, D.2    Ahmad, A.3
  • 52
    • 33646261143 scopus 로고    scopus 로고
    • Assessing the welfare of genetically altered mice
    • Wells, D.J., Playle, L.C., Enser, W.E. et al.. (2006) Assessing the welfare of genetically altered mice. Laboratory Animals, 40, 111-114
    • (2006) Laboratory Animals , vol.40 , pp. 111-114
    • Wells, D.J.1    Playle, L.C.2    Enser, W.E.3


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