In vivo, label-free, three-dimensional quantitative imaging of kidney microcirculation using Doppler optical coherence tomography

Laboratory Investigation

Volumn 91, Issue 11, 2011, Pages 1596-1604

  Wierwille, Jeremiah ^a   Andrews, Peter M ^b   Onozato, Maristela L ^c   Jiang, James ^d   Cable, Alex ^d   Chen, Yu ^a  

^a UNIVERSITY OF MARYLAND   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d THORLABS INC   (United States)

Author keywords

doppler optical coherence tomography (DOCT); glomerular blood flow; kidney microcirculation; optical coherence tomography (OCT)

Indexed keywords

ANGIOTENSIN II; MANNITOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DOPPLER OPTICAL COHERENCE TOMOGRAPHY; GLOMERULUS; IN VIVO STUDY; KIDNEY BLOOD FLOW; KIDNEY CIRCULATION; KIDNEY FUNCTION; LAPAROTOMY; MALE; MICROCIRCULATION; NONHUMAN; OPTICAL COHERENCE TOMOGRAPHY; PRIORITY JOURNAL; RAT; THREE DIMENSIONAL IMAGING;

ANALYSIS OF VARIANCE; ANGIOTENSIN II; ANIMALS; IMAGING, THREE-DIMENSIONAL; KIDNEY GLOMERULUS; MALE; MANNITOL; MICROCIRCULATION; RATS; RATS, WISTAR; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 80155177964     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2011.112     Document Type: Article

References (74)

1. Ogasawara Y, Takehara K, Yamamoto T, et al. Quantitative blood velocity mapping in glomerular capillaries by in vivo observation with an intravital videomicroscope. Methods Inf Med 2000;39:175-178. (Pubitemid 30423308)
2. Ibrahim HN, Hostetter TH. Diabetic nephropathy. J Am Soc Nephrol 1997;8:487-493. (Pubitemid 127454185)
3. O'Bryan GT, Hostetter TH. The renal hemodynamic basis of diabetic nephropathy. Semin Nephrol 1997;17:93-100. (Pubitemid 27124034)
4. Ichikawa I, Fogo A. Focal segmental glomerulosclerosis. Pediatr Nephrol 1996;10:374-391. (Pubitemid 26171093)
5. Szabo Z, Xia J, Mathews WB, et al. Future direction of renal positron emission tomography. Semin Nucl Med 2006;36:36-50. (Pubitemid 41779366)
6. Juillard L, Janier MF, Fouque D, et al. Dynamic renal blood flow measurement by positron emission tomography in patients with CRF. Am J Kidney Dis 2002;40:947-954. (Pubitemid 35265474)
7. Kudomi N, Koivuviita N, Liukko KE, et al. Parametric renal blood flow imaging using [15O]H2O and PET. Eur J Nucl Med Mol Imaging 2009;36:683-691.
8. Nitzsche EU, Choi Y, Killion D, et al. Quantification and parametric imaging of renal cortical blood flow in vivo based on Patlak graphical analysis. Kidney Int 1993;44:985-996. (Pubitemid 23316466)
9. Middlekauff HR, Nitzsche EU, Nguyen AH, et al. Modulation of renal cortical blood flow during static exercise in humans. Circ Res 1997;80:62-68. (Pubitemid 27030369)
10. Alpert NM, Rabito CA, Correia DJ, et al. Mapping of local renal blood flow with PET and H(2)(15)O. J Nucl Med 2002;43:470-475. (Pubitemid 34286340)
11. Michoux N, Montet X, Pechere A, et al. Parametric and quantitative analysis of MR renographic curves for assessing the functional behaviour of the kidney. Eur J Radiol 2005;54:124-135. (Pubitemid 40417481)
12. Vallee JP, Lazeyras F, Khan HG, et al. Absolute renal blood flow quantification by dynamic MRI and Gd-DTPA. Eur Radiol 2000;10:1245-1252.
13. Bokacheva L, Rusinek H, Zhang JL, et al. Assessment of renal function with dynamic contrast-enhanced MR imaging. Magn Reson Imaging Clin N Am 2008;16:597-611, viii.
14. De Bazelaire C, Rofsky NM, Duhamel G, et al. Arterial spin labeling blood flow magnetic resonance imaging for the characterization of metastatic renal cell carcinoma(1). Acad Radiol 2005;12:347-357. (Pubitemid 40353765)
15. Akinbi H, Abbasi S, Hilpert PL, et al. Gastrointestinal and renal blood flow velocity profile in neonates with birth asphyxia. J Pediatr 1994; 125:625-627. (Pubitemid 24318441)
16. van Bel F, Guit GL, Schipper J, et al. Indomethacin-induced changes in renal blood flow velocity waveform in premature infants investigated with color Doppler imaging. J Pediatr 1991;118(Part 1):621-626.
17. Wong SN, Lo RN, Yu EC. Renal blood flow pattern by noninvasive Doppler ultrasound in normal children and acute renal failure patients. J Ultrasound Med 1989;8:135-141. (Pubitemid 19083901)
18. Yura T, Yuasa S, Fukunaga M, et al. Role for Doppler ultrasound in the assessment of renal circulation: effects of dopamine and dobutamine on renal hemodynamics in humans. Nephron 1995;71:168-175.
19. Kalantarinia K, Belcik JT, Patrie JT, et al. Real-time measurement of renal blood flow in healthy subjects using contrast-enhanced ultrasound. Am J Physiol Ren Physiol 2009;297:F1129-F1134.
20. Kay DH, Mazonakis M, Geddes C, et al. Ultrasonic microbubble contrast agents and the transplant kidney. Clin Radiol 2009;64:1081-1087.
21. Yamamoto T, Tada T, Brodsky SV, et al. Intravital videomicroscopy of peritubular capillaries in renal ischemia. Am J Physiol Renal Physiol 2002;282:F1150-F1155. (Pubitemid 34654481)
22. Angelescu M, Kraus T, Wiesel M, et al. Assessment of renal graft function by perioperative monitoring of cortical microcirculation in kidney transplantation. Transplantation 2003;75:1190-1196. (Pubitemid 36513020)
23. Anaise D, Oster ZH, Atkins HL, et al. Cortex perfusion index: a sensitive detector of acute rejection crisis in transplanted kidneys. J Nucl Med 1986;27:1697-1701. (Pubitemid 17186224)
24. Hamilton D, Miola UJ, Payne MC. The renal transplant perfusion index: reduction in the error and variability. Eur J Nucl Med 1994;21:232-238. (Pubitemid 24081684)
25. Andrews PM, Petroll WM, Cavanagh HD, et al. Tandem scanning confocal microscopy (TSCM) of normal and ischemic living kidneys. Am J Anat 1991;191:95-102.
26. Andrews PM, Khirabadi BS, Bengs BC. Using tandem scanning confocal microscopy to predict the status of donor kidneys. Nephron 2002;91: 148-155. (Pubitemid 34522845)
27. Campo-Ruiz V, Lauwers GY, Anderson RR, et al. Novel virtual biopsy of the kidney with near infrared, reflectance confocal microscopy: a pilot study in vivo and ex vivo. J Urol 2006;175:327-336. (Pubitemid 41797198)
28. Kang JJ, Toma I, Sipos A, et al. Quantitative imaging of basic functions in renal (patho)physiology. Am J Physiol Renal Physiol 2006;291: F495-F502. (Pubitemid 44148139)
29. Dunn KW, Sandoval RM, Kelly KJ, et al. Functional studies of the kidney of living animals using multicolor two-photon microscopy. Am J Physiol Cell Physiol 2002;283:C905-C916. (Pubitemid 34920323)
30. Yu W, Sandoval RM, Molitoris BA. Rapid determination of renal filtration function using an optical ratiometric imaging approach. Am J Physiol Renal Physiol 2007;292:F1873-F1880. (Pubitemid 47105377)
31. Clark AL, Gillenwater A, Alizadeh-Naderi R, et al. Detection and diagnosis of oral neoplasia with an optical coherence microscope. J Biomed Opt 2004;9:1271-1280. (Pubitemid 40168143)
32. Huang D, Swanson EA, Lin CP, et al. Optical coherence tomography. Science 1991;254:1178-1181. (Pubitemid 21917444)
33. Chen Z, Milner TE, Srinivas S, et al. Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography. Opt Lett 1997; 22:1119-1121. (Pubitemid 127562050)
34. Chen Y, Andrews PM, Aguirre AD, et al. High-resolution threedimensional optical coherence tomography imaging of kidney microanatomy ex vivo. J Biomed Opt 2007;12:034008.
35. Andrews PM, Chen Y, Onozato ML, et al. High-resolution optical coherence tomography imaging of the living kidney. Lab Invest 2008;88:441-449. (Pubitemid 351432776)
36. Li Q, Onozato ML, Andrews PM, et al. Automated quantification of microstructural dimensions of the human kidney using optical coherence tomography (OCT). Opt Express 2009;17:16000-16016.
37. Onozato ML, Andrews PM, Li Q, et al. Optical coherence tomography of human kidney. J Urol 2010;183:2090-2094.
38. Tojo A. Optical coherence tomography in the kidney: a step toward echo microscopy. J Urol 2010;183:1669-1670.
39. Yang VXD, Gordon M, Qi B, et al. High speed, wide velocity dynamic range Doppler optical coherence tomography (Part I): System design, signal processing, and performance. Opt Express 2003;11:794-809.
40. Yazdanfar S, Rollins AM, Izatt JA. Imaging and velocimetry of the human retinal circulation with color Doppler optical coherence tomography. Opt Lett 2000;25:1448-1450.
41. Yu L, Chen Z. Doppler variance imaging for three-dimensional retina and choroid angiography. J Biomed Opt 2010;15:016029.
42. Wang Y, Bower BA, Izatt JA, et al. Retinal blood flow measurement by circumpapillary Fourier domain Doppler optical coherence tomography. J Biomed Opt 2008;13:064003.
43. Werkmeister RM, Dragostinoff N, Pircher M, et al. Bidirectional Doppler fourier-domain optical coherence tomography for measurement of absolute flow velocities in human retinal vessels. Opt Lett 2008; 33:2967-2969.
44. Barton J, Izatt JA, Kulkarni MD, et al. Three-dimensional reconstruction of blood vessels from in vivo color Doppler optical coherence tomography images. Dermatology 1999;198:355-361. (Pubitemid 29335728)
45. Zhao Y, Chen Z, Saxer C, et al. Doppler standard deviation imaging for clinical monitoring of in vivo human skin blood flow. Opt Lett 2000;25:1358-1360.
46. Li H, Standish BA, Mariampillai A, et al. Feasibility of interstitial Doppler optical coherence tomography for in vivo detection of microvascular changes during photodynamic therapy. Lasers Surg Med 2006;38: 754-761. (Pubitemid 44522031)
47. Yang VXD, Tang SJ, Gordon ML, et al. Endoscopic Doppler optical coherence tomography in the human GI tract: initial experience. Gastrointest Endosc 2005;61:879-890. (Pubitemid 40779424)
48. Hackbarth H, Buttner D, Jarck D, et al. Distribution of glomeruli in the renal cortex of Munich Wistar Fromter (MWF) rats. Ren Physiol 1983;6:63-71. (Pubitemid 13163653)
49. Stahl WM. Effect of Mannitol on the Kidney: Changes in Intrarenal Hemodynamics. N Engl J Med 1965;272:382-386.
50. Lindstrom KE, Ronnstedt L, Jaremko G, et al. Physiological and morphological effects of perfusing isolated rat kidneys with hyperosmolal mannitol solutions. Acta Physiol Scand 1999;166:231-238. (Pubitemid 29389469)
51. Behnia R, Koushanpour E, Brunner EA. Effects of hyperosmotic mannitol infusion on hemodynamics of dog kidney. Anesth Analg 1996;82:902-908. (Pubitemid 26131015)
52. Deng X, Welch WJ, Wilcox CS. Role of nitric oxide in short-term and prolonged effects of angiotensin II on renal hemodynamics. Hypertension 1996;27:1173-1179. (Pubitemid 26140676)
53. Ekelund L, Gothlin J. Effect of angiotensin on normal renal circulation determined by angiography and a dye dilution technique. Acta Radiol Diagn (Stockh) 1977;18:39-48. (Pubitemid 8070645)
54. Gothlin JH, Krakenes J, Tvete S. The effects of angiotensin on the diagnostics and haemodynamics in renal angiography. Eur J Radiol 1983;3:328-330. (Pubitemid 14204032)
55. Hall JE, Granger JP. Renal hemodynamic actions of angiotensin II: interaction with tubuloglomerular feedback. Am J Physiol 1983;245: R166-R173. (Pubitemid 13030746)
56. Denton KM, Anderson WP, Sinniah R. Effects of angiotensin II on regional afferent and efferent arteriole dimensions and the glomerular pole. Am J Physiol Regul Integr Comp Physiol 2000;279:R629-R638.
57. Yang VXD, Gordon M, Tang SJ, et al. High speed, wide velocity dynamic range Doppler optical coherence tomography (Part III): in vivo endoscopic imaging of blood flow in the rat and human gastrointestinal tracts. Opt Express 2003;11:2416-2424.
58. Srinivasan VJ, Sakadzic S, Gorczynska I, et al. Quantitative cerebral blood flow with optical coherence tomography. Opt Express 2010;18:2477-2494.
59. Molitoris BA, Sandoval RM. Intravital multiphoton microscopy of dynamic renal processes. Am J Physiol Renal Physiol 2005;288:F1084-F1089. (Pubitemid 40677076)
60. Li B, Yao J, Kawamura K, et al. Real-time observation of glomerular hemodynamic changes in diabetic rats: effects of insulin and ARB. Kidney Int 2004;66:1939-1948. (Pubitemid 41094318)
61. Schmitz V, Schaser KD, Olschewski P, et al. In vivo visualization of early microcirculatory changes following ischemia/reperfusion injury in human kidney transplantation. Eur Surg Res 2008;40:19-25.
62. Adler DC, Chen Y, Huber R, et al. Three-dimensional endomicroscopy using optical coherence tomography. Nat Photonics 2007;1:709-716.
63. Li X, Chudoba C, Ko T, et al. Imaging needle for optical coherence tomography. Opt Lett 2000;25:1520-1522.
64. Yang VXD, Mao YX, Munce N, et al. Interstitial Doppler optical coherence tomography. Opt Lett 2005;30:1791-1793. (Pubitemid 41083732)
65. Hariri LP, Bonnema GT, Schmidt K, et al. Laparoscopic optical coherence tomography imaging of human ovarian cancer. Gynecol Oncol 2009;114:188-194.
66. Wieser W, Biedermann BR, Klein T, et al. Multi-megahertz OCT: High quality 3D imaging at 20 million A-Scans and 4.5 GVoxels per second. Opt Express 2010;18:14685-14704.
67. Mariampillai A, Leung MK, Jarvi M, et al. Optimized speckle variance OCT imaging of microvasculature. Opt Lett 2010;35:1257-1259.
68. Makita S, Hong Y, Yamanari M, et al. Optical coherence angiography. Opt Express 2006;14:7821-7840. (Pubitemid 44277517)
69. Zhi Z, Jung Y, Jia Y, et al. High sensitive imaging of renal microcirculation in vivo using ultrahigh sensitive optical microangiography. Biomed Opt Express 2011;2:1059-1068.
70. Chen CW, Betz MW, Fisher JP, et al. Macroporous hydrogel scaffolds and their characterization by optical coherence tomography. Tissue Eng: Part C 2011;17:101-112.
71. Dunkers J, Cicerone M, Washburn N. Collinear optical coherence and confocal fluorescence microscopies for tissue engineering. Opt Express 2003;11:3074-3079.
72. Tang S, Sun CH, Krasieva TB, et al. Imaging subcellular scattering contrast by using combined optical coherence and multiphoton microscopy. Opt Lett 2007;32:503-505. (Pubitemid 46363508)
73. Vinegoni C, Ralston T, Tan W, et al. Integrated structural and functional optical imaging combining spectral-domain optical coherence and multiphoton microscopy. Appl Phys Lett 2006;88:053901.
74. Regan MC, Young LS, Geraghty J, et al. Regional renal blood flow in normal and disease states. Urol Res 1995;23:1-10.