Indoxyl sulfate, a representative uremic toxin, suppresses erythropoietin production in a HIF-dependent manner

Laboratory Investigation

Volumn 91, Issue 11, 2011, Pages 1564-1571

  Chiang, Chih Kang ^a,b   Tanaka, Tetsuhiro ^a   Inagi, Reiko ^a   Fujita, Toshiro ^a   Nangaku, Masaomi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

chronic kidney disease; erythropoietin; hypoxia inducible factor; indoxyl sulfate; uremic toxin

Indexed keywords

COBALT CHLORIDE; ERYTHROPOIETIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INDICAN; LUCIFERASE; MESSENGER RNA;

ANEMIA; ARTICLE; CELL STIMULATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DIALYSIS; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IN VIVO STUDY; KIDNEY TUBULE CELL; OXYGEN SENSING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; COBALT; ENZYME-LINKED IMMUNOSORBENT ASSAY; ERYTHROPOIETIN; GENE EXPRESSION REGULATION; HEP G2 CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; INDICAN; INDOLES; KIDNEY FAILURE, CHRONIC; LUCIFERASES; OXYGEN; RATS; UREMIA;

EID: 80155151941     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2011.114     Document Type: Article

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