Synovial infiltration with CD79a-positive B cells, but not other B cell lineage markers, correlates with joint destruction in rheumatoid arthritis

Journal of Rheumatology

Volumn 38, Issue 11, 2011, Pages 2301-2308

  Mo, Ying Qian ^a   Dai, Lie ^a   Zheng, Dong Hui ^a   Zhu, Lang Jing ^a   Wei, Xiu Ning ^a   Pessler, Frank ^b,c   Shen, Jun ^a   Zhang, Bai Yu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

B cell lineage; Joint destruction; Rheumatoid arthritis; Synovitis

Indexed keywords

ANALGESIC AGENT; CD20 ANTIGEN; CD3 ANTIGEN; CD34 ANTIGEN; CD38 ANTIGEN; CD68 ANTIGEN; CD79A ANTIGEN; COMPLEMENT COMPONENT C3D RECEPTOR; CORTICOSTEROID; DISEASE MODIFYING ANTIRHEUMATIC DRUG; HERBACEOUS AGENT; HYDROXYCHLOROQUINE; LEFLUNOMIDE; METHOTREXATE; SALAZOSULFAPYRIDINE;

ADULT; AGED; AREA UNDER THE CURVE; ARTHRALGIA; ARTHROPATHY; ARTICLE; B LYMPHOCYTE; CELL DENSITY; CELL LINEAGE; CHINESE; CONTROLLED STUDY; DISEASE ACTIVITY; ENDOTHELIUM CELL; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; JOINT BIOPSY; JOINT DESTRUCTION; JOINT RADIOGRAPHY; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MALE; OSTEOARTHRITIS; PLASMA CELL; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; RHEUMATOID ARTHRITIS; SCORING SYSTEM; SYNOVITIS; SYNOVIUM;

ADULT; AGED; ANTIGENS, CD; ANTIGENS, CD20; ANTIGENS, CD79; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; ARTHRITIS, RHEUMATOID; B-LYMPHOCYTES; BIOLOGICAL MARKERS; BIOPSY, NEEDLE; CASE-CONTROL STUDIES; CELL LINEAGE; CHINA; FEMALE; HUMANS; KNEE JOINT; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE; RECEPTORS, COMPLEMENT 3D; SEVERITY OF ILLNESS INDEX; SYNOVIAL MEMBRANE;

EID: 80155126108     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.110615     Document Type: Article

References (28)

1. Edwards JC, Szczepanski L, Szechinski J, Filipowicz-Sosnowska A, Emery P, Close DR, et al. Efficacy of B-cell targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med 2004;350:2572-81. (Pubitemid 38758544)
2. Takemura S, Braun A, Crowson C, Kurtin PJ, Cofield RH, O'Fallon WM, et al. Lymphoid neogenesis in rheumatoid synovitis. J Immunol 2001;167:1072-80. (Pubitemid 32660867)
3. Svensson L, Jirholt J, Holmdahl R, Jansson L. B cell-deficient mice do not develop type II collagen-induced arthritis (CIA). Clin Exp Immunol 1998;111:521-6. (Pubitemid 28160894)
4. Takemura S, Klimiuk PA, Braun A, Goronzy JJ, Weyand CM. T cell activation in rheumatoid synovium is B cell dependent. J Immunol 2001;167:4710-8. (Pubitemid 32954353)
5. Kavanaugh A, Rosengren S, Lee SJ, Hammaker D, Firestein GS, Kalunian K, et al. Assessment of rituximab's immunomodulatory synovial effects (ARISE trial). 1: Clinical and synovial biomarker results. Ann Rheum Dis 2008;67:402-8. (Pubitemid 351281278)
6. Teng YK, Levarht EW, Toes RE, Huizinga TW, van Laar JM. Residual inflammation after rituximab treatment is associated with sustained synovial plasma cell infiltration and enhanced B cell repopulation. Ann Rheum Dis 2009;68:1011-6.
7. Pessler F, Ogdie A, Diaz-Torne C, Dai L, Yu X, Einhorn E, et al. Subintimal Ki-67 as a synovial tissue biomarker for inflammatory arthropathies. Ann Rheum Dis 2008;67:162-7. (Pubitemid 351183303)
8. Pessler F, Dai L, Diaz-Torne C, Gomez-Vaquero C, Paessler ME, Zheng DH, et al. The synovitis of "non-inflammatory" orthopedic arthropathies: A quantitative histologic and immunohistochemical analysis. Ann Rheum Dis 2008;67:1184-7.
9. Koh ET, Seow A, Pong LY, Koh WH, Chan L, Howe HS, et al. Cross cultural adaptation and validation of the Chinese Health Assessment Questionnaire for use in rheumatoid arthritis. J Rheumatol 1998;25:1705-8. (Pubitemid 28439262)
10. Sharp JT, Young DY, Bluhm GB, Brook A, Brower AC, Corbett M, et al. How many joints in the hands and wrists should be included in a score of radiologic abnormalities used to assess rheumatoid arthritis? Arthritis Rheum 1985;28:1326-35. (Pubitemid 16156142)
11. Schumacher HR Jr, Kulka JP. Needle biopsy of the synovial membrane - experience with the Parker-Pearson technique. N Engl J Med 1972;286:416-9.
12. Gerlag D, Tak PP. Synovial biopsy. Best Pract Res Clin Rheumatol 2005;19:387-400. (Pubitemid 40796528)
13. Krenn V, Morawietz L, Häupl T, Neidel J, Petersen I, König A. Grading of chronic synovitis - a histopathological grading system for molecular and diagnostic pathology. Pathol Res Pract 2002;198:317-25. (Pubitemid 34679100)
14. Slansky E, Li J, Häupl T, Morawietz L, Krenn V, Pessler F. Quantitative determination of the diagnostic accuracy of the synovitis score and its components. Histopathology 2010;57:436-43.
15. Bresnihan B, Cunnane G, Youssef P, Yanni G, Fitzgerald O, Mulherin D. Microscopic measurement of synovial membrane inflammation in rheumatoid arthritis: Proposals for evaluation of tissue samples by quantitative analysis. Br J Rheumatol 1998;37:636-42.
16. Youssef PP, Smeets TJ, Bresnihan B, Cunnane G, Fitzgerald O, Breedveld F, et al. Microscopic measurement of cellular infiltration in the rheumatoid arthritis synovial membrane: A comparison of semiquantitative and quantitative analysis. Br J Rheumatol 1998;37:1003-7.
17. Ogdie A, Li J, Dai L, Paessler ME, Yu X, Diaz-Torne C, et al. Identification of broadly discriminatory tissue biomarkers of synovitis with binary and multicategory receiver operating characteristic analysis. Biomarkers 2010;15:183-90.
18. Pessler F, Dai L, Diaz-Torne C, Ogdie A, Gomez-Vaquero C, Paessler ME, et al. Increased angiogenesis and cellular proliferation as hallmarks of the synovium in chronic septic arthritis. Arthritis Rheum 2008;59:1137-46.
19. Krenn V, Morawietz L, Burmester GR, Kinne RW, Mueller-Ladner U, Muller B, et al. Synovitis score: Discrimination between chronic low-grade and high-grade synovitis. Histopathology 2006;49:358-64. (Pubitemid 44401542)
20. Chu PG, Arber DA. CD79: A review. Appl Immunohistochem Mol Morphol 2001;9:97-106. (Pubitemid 32479221)
21. Kraan MC, Reece RJ, Smeets TJ, Veale DJ, Emery P, Tak PP. Comparison of synovial tissues from the knee joints and the small joints of rheumatoid arthritis patients: Implications for pathogenesis and evaluation of treatment. Arthritis Rheum 2002;46:2034-8.
22. Yanni G, Whelan A, Feighery C, Bresnihan B. Synovial tissue macrophages and joint erosion in rheumatoid arthritis. Ann Rheum Dis 1994;53:39-44. (Pubitemid 24067407)
23. Kraan MC, Haringman JJ, Weedon H, Barg EC, Smith MD, Ahern MJ, et al. T cells, fibroblast-like synoviocytes, and granzyme B+ cytotoxic cells are associated with joint damage in patients with recent onset rheumatoid arthritis. Ann Rheum Dis 2004;63:483-8. (Pubitemid 38530189)
24. van der Heijde DM, van Riel PL, van Leeuwen MA, van 't Hof MA, van Rijswijk MH, van de Putte LB. Prognostic factors for radiographic damage and physical disability in early rheumatoid arthritis. A prospective follow-up study of 147 patients. Br J Rheumatol 1992;31:519-25.
25. Bonnerot C, Lankar D, Hanau D, Spehner D, Davoust J, Salamero J, et al. Role of B cell receptor Ig alpha and Ig beta subunits in MHC class II-restricted antigen presentation. Immunity 1995;3:335-47.
26. Minegishi Y, Coustan-Smith E, Rapalus L, Ersoy F, Campana D, Conley ME. Mutations in Ig-alpha (CD79a) result in a complete block in B-cell development. J Clin Invest 1999;104:1115-21. (Pubitemid 29536322)
27. Jimenez-Boj E, Redlich K, Türk B, Hanslik-Schnabel B, Wanivenhaus A, Chott A, et al. Interaction between synovial inflammatory tissue and bone marrow in rheumatoid arthritis. J Immunol 2005;175:2579-88. (Pubitemid 41113871)
28. Li Y, Chen F, Putt M, Koo YK, Madaio M, Cambier JC, et al. B cell depletion with anti-CD79 mAbs ameliorates autoimmune disease in MRL/lpr mice. J Immunol 2008;181:2961-72.