Preparation and characterization of chitosan lactate nanoparticles for the nasal delivery of enalaprilat

Journal of Biomedical Nanotechnology

Volumn 3, Issue 1, 2007, Pages 45-51

  Nanda, Biswarup ^a   Murthy, R S R ^a  

^a TIFAC CORE in NDDS   (India)

Author keywords

Chitosan lactate; Entrapment efficiency; Ex vivo permeation; Intranasal administration; Ionic gelation; Nanoparticles; Nasal toxicity

Indexed keywords

CHITOSAN; ENALAPRILAT; LACTIC ACID; NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE REGULATION; CANNULATION; CONFERENCE PAPER; CONTROLLED STUDY; CROSS LINKING; DIFFUSION; DISPERSION; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG DOSE REGIMEN; DRUG FORMULATION; DRUG PENETRATION; DRUG RELEASE; DRUG TRANSPORT; ENCAPSULATION; EX VIVO STUDY; GELATION; IN VIVO STUDY; NONHUMAN; NOSE MUCOSA; PARTICLE SIZE; PHARMACODYNAMICS; RAT; SCANNING ELECTRON MICROSCOPY; SHEEP; TOXICITY TESTING; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL;

EID: 45849149671     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2007.004     Document Type: Conference Paper

References (16)

1. R. Bommer, Encyclopedia of Pharmaceutical Technology, Dekker Series 1, 854 (2002).
2. T. J. Aspden, J. D. T. Mason, N. S. Jones, J. Lowe, Ø. Skaugrud, and L. Illum, Chitosan as a nasal delivery system: The effect of chitosan solutions on in vitro and in vivo mucociliary transport rates in human turbinates and volunteers. J. Pharm. Sci. 86, 509 (2000).
3. Y. Aktas, K. Andrieux, M. J. Alonso, P. Calvo, R. Neslihan Gürsoy, P. Couvreur, and Y. Capan, Preparation and in vitro evaluation of chitosan nanoparticles containing a caspase inhibitor. Int. J. Pharm. 298, 378 (2005).
4. P. Tengamnuay, A. Sahamethapat, A. Sailasuta, and A. K. Mitra, Chitosans as nasal absorption enhancers of peptides: Comparison between free amine chitosans and soluble salts. Int. J. Pharm. 197, 53(2000).
5. P. Ahlin, J. Kristl, A. Kristi, and F. Vrecěr, Investigation of polymeric nanoparticles as carriers of enalaprilat for oral administration. Int. J Pharm. 239, 113 (2002).
6. K. A. Janes and A J. Alonso, Depolymerized chitosan nanoparticles for protein delivery: Preparation and characterization. J. Appl. Poly. Sci. 88, 2769 (2003).
7. T. Cerchiara, B. Luppi, F. Bigucci, and V. Zecchi, Chitosan salts as nasal sustained delivery systems for peptidic drugs. J. Pharm. Pharmacol. 55, 1623 (2003).
8. D. R. Bhumkar and V. B. Pokharkar, Studies on effect of pH on cross-linking of chitosan with sodium tripolyphosphate: A technical note. AAPS Pharm. Sci. Tech. 7, 50 (2006).
9. A. Sunil Agnihotri, N. Nadagouda Mallikarjuna, and M. Tejraj, Recent advances on chitosan- based micro- and nanoparticles in drug delivery. J. Control. Rel. 100, 5 (2004).
10. A. M. De Campos, A. Sanchez, J. Maria, and Alonso, Chitosan nanoparticles: A new vehicle for the improvment of the delivery of drugs to the occular surface. Application to Cyclosporin A. Int. J Pharm. 224, 159 (2001).
11. He P. Davis, and L. SS. Illium, Sustained release chitosan microspheres prepared by novel spray drying methods. J. Microencapsul. 16, 343 (1999).
12. T. Cerchiara, B. Luppi, G. Chidichimo, F. Bigucci, and V. Zecchi, Chitosan and poly(methyl vinyl ether-co-maleic anhy-dride) microparticles as nasal sustained delivery systems. Eur J. Pharm. Biopharm. 61, 195 (2005).
13. N. G. M. Scipper, K. M. V. Arum, and P. Artursson, Chitosan as absorption enhancer of poorly absorbable drugs 1: Influence of molecular weight and degree of acetylation on drug transport across human intestinal epithelial (Caco-2) cells. Pharm. Res. 13, 1696 ( 1996).
14. A. M. de Campos, Y. Diebold, E. L. S. Carvailho, A. Sanchez, and M. J. Alonso, Chitosan nanoparticles as new ocular drug delivery systems. in vitro stability, in vivo fate, and cellular toxicity, J. Pharm. Res. 21, 803 (2004).
15. S. Dhawan, A. K. Singla, and V. R. Sinha, Evaluation of mucoadhesive properties of chitosan microspheres prepared by different methods. AAPS Pharm. Sci. Tech. 5, 67 (2004).
16. F. L. Mi, T. B. Wong, and S. S. Shyu, Sustained-release of oxytet-racycline from chitosan microspheres prepared by interfacial acylation and spray hardening methods. J. Microencapsul. 14, 577 (1997).