Mechanical characterization and insertion performance of hollow microneedle array for cell surgery

Journal of Micro/Nanolithography, MEMS, and MOEMS

Volumn 8, Issue 3, 2009, Pages

  Kawashima, Takahiro ^a   Sakai, Takahiro ^a   Kato, Norihisa ^a   Shibata, Takayuki ^a   Nomura, Mitsuyoshi ^a   Mineta, Takashi ^b   Makino, Eiji ^b  

^a TOYOHASHI UNIVERSITY OF TECHNOLOGY   (Japan)

^b HIROSAKI UNIVERSITY   (Japan)

Author keywords

Cell surgery; Cellular MEMS; Microelectromechanical systems (MEMS); Micromachining; Microneedles; Nanobiotechnology

Indexed keywords

BIOMOLECULES; CELLS; COMPOSITE MICROMECHANICS; FINITE ELEMENT METHOD; FRACTURE; FRACTURE TESTING; MECHANICAL STABILITY; MEMS; MICROELECTROMECHANICAL DEVICES; MICROMACHINING; NUCLEIC ACIDS; SILICA; SILICON COMPOUNDS; SILICON OXIDES; SURGERY;

ARTIFICIAL CELL; BENDING BEHAVIOR; CELL SURGERY; CELLULAR MEMS; CHIP-BASED SYSTEMS; FINITE ELEMENT METHOD ANALYSIS; FRACTURE TEST; LIVING CELL; MECHANICAL CHARACTERIZATIONS; MECHANICAL OSCILLATIONS; MICROELECTROMECHANICAL SYSTEMS (MEMS); MICROMACHINING TECHNIQUES; MICRONEEDLE ARRAYS; MICRONEEDLES; NEEDLE INSERTION; OSCILLATION FREQUENCY; RELATIVE VALUE; SHARP TIP; SURFACE AREA; VISCO-ELASTIC MATERIAL; VISCOUS RESISTANCE;

NEEDLES;

EID: 80055109162     PISSN: 19325150     EISSN: 19325134     Source Type: Journal    
DOI: 10.1117/1.3206971     Document Type: Article

References (13)

1. M. J. Madou, Fundamentals of Microfabrication: The Science of Miniaturization, 2nd ed. CRC Press, Boca Raton, FL, (2002).
2. C. Yi, C.-W. Li, S. Ji, and M. Yang, "Microfluidics technology for manipulation and analysis of biological cells," Anal. Chim. Acta 560, 1-23 (2006).
3. R. Bashir, "BioMEMS: state-of-the-art in detection, opportunities and prospects," Adv. Drug Delivery Rev. 56, 1565-1586 (2004).
4. L. Leoni and T. A. Desai, "Micromachined biocapsules for cell-based sensing and delivery," Adv. Drug Delivery Rev. 56, 211-229 (2004).
5. K. Durick and P. Negulescu, "Celluar biosensors for drug discovery," Biosens. Bioelectron. 16, 587-592 (2001).
6. K. Bhadriraju and C. S. Chen, "Engineering cellular microenvironments to improve cell-based drug testing," Drug Discovery Today 7, 612-620 (2002).
7. H. Matsuoka, T. Komazaki, Y. Mukai, M. Shibusawa, H. Akane, A. Chaki, N. Uetake, and M. Saito, "High throughput easy microinjection with a single-cell manipulation supporting robot," J. Biotechnol. 116, 185-194 (2005).
8. J. D. Zahn, N. H. Talbot, D. Liepmann, A. P. Pisano, " Microfabricated polysilicon microneedles for minimally invasive biomedical devices," Biomed. Microdevices 2, 295-303 (2000).
9. E. V. Mukerjee, S. D. Collins, R. R. Isseroff, and R. L. Smith, "Microneedle array for transdermal biological fluid extraction and in situ analysis," Sens. Actuators, A A-114, 267-275 (2004).
10. H. J. G. E. Gardeniers, R. Luttge, E. J. W. Berenschot, M. J. de Boer, S. Y. Yeshurun, M. Hefetz, R. van't Oever, and A. van den Berg, "Silicon micromachined hollow microneedles for transdermal liquid transport," J. Microelectromech. Syst. 12, 855-862 (2005).
11. K. Chun, G. Hashiguchi, H. Toshiyoshi, and H. Fujita, "Fabrication of array of hollow microcapillaries used for injection of genetic materials into animal/plant cells," Jpn. J. Appl. Phys. 38 (Part 2-3A), L279-L281 (1999).
12. T. Shibata, A. Nakanishi, T. Sakai, N. Kato, T. Kawashima, T. Mineta, and E. Makino, "Fabrication and mechanical characterization of microneedle array for cell surgery," in Tech. Digest 14th Int. Conf. Solid-State Sensors, Actuators and Microsystems (Transducers'07), Vol. 1, pp. 719-722, IEEE, Piscataway, NJ (2007).
13. S. Franssila, Introduction to Microfabrication John Wiley and Sons, Chichester, UK (2004).