Thoracic epidural bupivacaine attenuates inflammatory response, intestinal lipid peroxidation, oxidative injury, and mucosal apoptosis induced by mesenteric ischemia/reperfusion

Anesthesia and Analgesia

Volumn 113, Issue 5, 2011, Pages 1226-1232

  Bedirli, Nurdan ^a   Akyürek, Nalan ^a   Kurtipek, Omer ^a   Kavutcu, Mustafa ^a   Kartal, Seyfi ^a   Cavunt Bayraktar, Asl ^a  

^a GAZI UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; CATALASE; GLUTATHIONE PEROXIDASE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; MALONALDEHYDE; MYELOPEROXIDASE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG SCREENING; ENZYME ACTIVITY; INFLAMMATION; INJURY SCALE; INTESTINE INJURY; ISCHEMIA; LIPID PEROXIDATION; MALE; MESENTERIC ISCHEMIA REPERFUSION; NEUTROPHIL; NONHUMAN; ORGAN WEIGHT; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SUPERIOR MESENTERIC ARTERY; THORAX EPIDURAL ANESTHESIA;

ANESTHESIA, EPIDURAL; ANESTHETICS, LOCAL; ANIMALS; APOPTOSIS; BUPIVACAINE; CATALASE; CATHETERIZATION; CYTOKINES; GLUTATHIONE PEROXIDASE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; INTESTINAL MUCOSA; INTESTINES; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; MESENTERIC ARTERY, SUPERIOR; OXIDATIVE STRESS; PEROXIDASE; RATS; RATS, WISTAR; REPERFUSION INJURY; SUPEROXIDE DISMUTASE; THORACIC VERTEBRAE;

EID: 80055100110     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ANE.0b013e31822b8984     Document Type: Article

References (43)

1. Homer-Vanniasinkam S, Crinnion JN, Gough MJ. Postischemic organ dysfunction: A review. Eur J Vasc Endovasc Surg 1997;14:195-203
2. Di Paola R, Melani A, Esposito E, Mazzon E, Petemiti I, Brementi P, Pedata F. Adenosine A2A receptor-selective stimulation reduces signalling pathways in the development of intestine ischemia and injury. Shock 2010;33:541-51
3. Flessas II, Papalois AE, Toutouzas K, Zagouri F, Zografos GC. Effects of lazoroids on intestinal ischemia and reperfusion injury in experimental models. J Surg Res 2010;31:1-10
4. Herbert GS, Steele SR. Acute and chronic mesenteric ischemia. Surg Clin North Am 2007;87:1115-8
5. Hassoun HT, Kone BC, Mercer DW. Post-injury multiple organ failure: the role of the gut. Shock 2001;15:1-4
6. Bedirli A, Kerem M, Pasaoglu H, Akyurek N, Tezcaner T, Elbeg S, Memis L. Beta-glucan attenuates inflammatory cytokine release and prevents acute lung injury in an experimental model of sepsis. Shock 2007;27:397-401
7. Schoemberg MH, Beger HG. Reperfusion injury after intestinal ischemia. Crit Care Med 1993;21:1376-86
8. Cuzzocrea S, Mazzon E, Dugo L, Caputi AP, Aston K, Riley DP, Salvemini D. Protective effects of a new stable, highly active SOD mimetics, M40401 in splanchnic artery occlusion and reperfusion. Br J Pharmacol 2001;132:19-29
9. Requena JR, Fu MX, Ahmed MU, Jenkins AJ, Lyons TJ, Thorpe SR. Lipoxidation products as biomarkers of oxidative damage to proteins during lipid peroxidation reactions. Nephrol Dial Transplant 19965:48-53
10. Naito Y, Takagi T, Uchiyama K, Handa O, Tomatsuri N, Imamoto E, Kokura S. Suppression of intestinal ischemia- reperfusion injury by a specific peroxisome proliferatoractivated receptor-gamma ligand, pioglitazone, in rats. Redox Rep 2002;7:294-9
11. Pehlivan M, Dalbeler Y, Hazinedaroglu S, Arikan Y, Erkek AB, Gunal O, Turkcanpar N. An assessment of the effect of Ginkgo Biloba EGb 761 on ischemia reperfusion injury of intestine. Hepatogastroenterology 2002;49:201-4
12. Kubes P. The role of adhesion molecules and nitric oxide in intestinal and hepatic ischemia/reperfusion. Hepatogastroenterology 1999;46:1458-63
13. Daudel F, Freise H, Westpal M, Stubbe HD, Lauder S, Bone HG, Van Aken H. Continuous thoracic epidural anesthesia improves gut mucosal microcirculation in rats with sepsis. Shock 2007;5:610-4
14. Sielenkamper AW, Eicker K, Van Aken H. Thoracic epidural anesthesia increases mucosal perfusion in ileum of rats. Anesthesiology 2000;93:844-51
15. Ai K, Kotake Y, Satoh T, Serita R, Takeda J, Morisaki H. Epidural anesthesia retards intestinal acidosis and reduces portal vein endotoxin concentrations during progressive hypoxia in rabbits. Anesthesiology 2001;94:263-9
16. Freise H, Lauer S, Anthonsen S, Hlouschek V, Minin E, Ficher LG, Lerch MM. Thoracic epidural analgesia augments ileal mucosal capillary perfusion and improves survival in severe acute pancreatitis in rats. Anesthesiology 2006;105:354-9
17. Sielenkamper AW, Van Aken H. Thoracic epidural anesthesia: more than just anesthesia/analgesia. Anesthesiology 2003;99: 523-5
18. Freise H, Anthonsen S, Fischer LG, Van Aken H, Sielenkamper AW. Continuous thoracic epidural anesthesia induces segmental sympathetic block in the awake rat. Anesth Analg 2005;100:255-62
19. Bradford MM. A rapid and sensitive method for quantization of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54
20. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967;70:158-69
21. Umeki S, Sumi M, Niki Y, Soejima R. Concentrations of superoxide dismutase and superoxide anion in blood of patients with respiratory infections and compromised immune systems. Clin Chem 1987;33:2230-3
22. Aebi H. Catalase. In: Bergmeyer, HU, ed. Methods of Enzymatic Analysis. New York: Academic Press, 1974:673-84
23. Claiborne A. Catalase activity. In: Greenwald, RA, ed. CRC Handbook of Methods for Oxygen Radical Research. Boca Raton, FL: CRC Press Inc. 1985:283-4
24. Chiu CJ, McArdle AH, Brown R, Scott HJ, Gurd FN. Intestinal mucosal lesion in low-flow states. A morphological, hemodynamic, and metabolic reappraisal. Arch Surg 1970;101:478-83
25. Mallick IH, Yang W, Winslet MC, Seifalian AM. Ischemia- reperfusion injury of the intestine and protective strategies against injury. Dig Dis Sci 2004;49:1359-77
26. Masuno T, Moore EE, Cheng AM, Sarin EL, Banerjee A. Bioactivity of postshock mesenteric lymph depends on the depth and duration of hemorrhagic shock. Shock 2006;26:285-9
27. Clemente A, Carli F. The physiological effects of thoracic epidural anesthesia and analgesia on cardiovascular, respiratory and gastrointestinal systems. Minerva Anesthesiol 2008;74:549-63
28. Adolphs J, Schmidt D, Mousa S, Kamin B, Korsukewitz I, Habazetti H, Schafer M, Welte M. Thoracic epidural anesthesia attenuates hemorrhage-induced impairment of intestinal perfusion in rats. Anesthesiology 2003 99 685-92.
29. Low JH. Survey of epidural analgesia management in general intensive care units in England. Acta Anesth Scand 2002;46: 799-805
30. Mann C, Pouzeratte Y, Boccara G, Peccoux C, Vergne C, Brunat G, Domergue J, Millat B, Colson P. Comparison of intravenous or epidural patient controlled analgesia in elderly after major abdominal surgery. Anesthesiology 2000;92:433-41
31. Hogan Q, Stekiel T, Stadnicka A, Bosnjak ZJ, Kampine JP. Region of epidural blockade determines sympathetic and mesenteric capacitance effects in rabbits. Anesthesiology 1995;83:604-10
32. Bruas JA, Reenstra WR. Endothelial-neutrophil interactions during ischemia and reperfusion injury: basic mechanisms of hyperbaric oxygen. Neurol Res 2007;29:127-31
33. Sukhotnik I, Coran AG, Greenblatt R, Brod V, Mogilner J, Shiloni E, Shaoul R, Bitterman H. Effect of 100% oxygen on E-selectin expression, recruitment of neutrophils and enterocyte apoptosis following intestinal ischemia-reperfusion in a rat. Pediatr Surg Int 2008;24:29-35
34. Winterbourn CC, Ketle AJ. Biomarkers of myeloperoxidasederived hypochlorous acid. Free Radic Biol Med 2000;29:403-9
35. Haglund U. Gut ischemia. Gut 1994;35:73-6
36. Chiu CJ, McArdle AH, Brown R, Brown R, Scott HJ, Gurd FN. Intestinal mucosal lesion in low-flow states: A morphological, hemodynamic and metabolic reappraisal. Arch Surg 1970;101: 478-83
37. Wagner R, Gabbert H, Höhn P. Ischemia and post-ischemic regeneration of the small intestinal mucosa. Virchows Arch 1979;31:259-76
38. Liu KX, Chen SQ, Huang WQ, Li YS, Irwin MG, Xia Z. Propofol pretreatment reduces ceramide production and attenuates intestinal mucosal apoptosis induced by intestinal ischemia/reperfusion in rats. Anesth Analg 2008;107:1884-91
39. Ikeda H, Suzuki Y, Suzuki M, Koike M, Tamura J, Tong J, Nomura M, Itoh G. Apoptosis is a major mode of cell death caused by ischaemia and ischaemia/reperfusion injury to the rat intestinal epithelium. Gut 1998;42:530-7
40. Sun Z, Wang X, Deng X, Lasson A, Wallen R, Hallberg E, Andersson R. The influence of intestinal ischemia and reperfusion on bidirectional intestinal barrier permeability, cellular membrane integrity, proteinase inhibitors, and cell death in rats. Shock 1998;10:203-12
41. Hollmann MW, Durieux ME. Local anesthetics and the inflammatory response: A new therapeutic indication? Anesthesiology 2000;93:858-75
42. Moselli NM, Baricocchi E, Ribero D, Sottile A, Suita L, Debernardi F. Intraoperative epidural analgesia prevents the early proinflammatory response to surgical trauma. results from a prospective randomized clinical trial of intraoperative epidural versus general analgesia. Ann Surg Oncol. 2011 Apr
43. [Epub ahead of print]