Inhibition of voltage-gated sodium channels by emulsified isoflurane may contribute to its subarachnoid anesthetic effect in beagle dogs

Regional Anesthesia and Pain Medicine

Volumn 36, Issue 6, 2011, Pages 553-559

  Zhou, Cheng ^a,b   Wu, Wei ^a   Liu, Jin ^a   Liao, Da Qing ^a   Kang, Yi ^a   Chen, Xiang Dong ^a  

^a SICHUAN UNIVERSITY   (China)

^b West China School of Pharmacy   (China)

Author keywords

[No Author keywords available]

Indexed keywords

EMULSIFIED ISOFLURANE; INTRALIPID; ISOFLURANE; LIDOCAINE; PENTOBARBITAL; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL EXPERIMENT; ARTICLE; CHANNEL GATING; CONSCIOUSNESS; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG INHIBITION; DRUG MECHANISM; IC 50; MOTOR PERFORMANCE; NOCICEPTION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RANDOMIZATION; RAT; SODIUM CURRENT; SPINAL ANESTHESIA; SPINAL CORD NERVE CELL; WHOLE CELL;

ANESTHESIA, EPIDURAL; ANIMALS; ANIMALS, NEWBORN; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; EMULSIONS; INJECTIONS, SPINAL; ISOFLURANE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; SUBARACHNOID SPACE;

EID: 80055092626     PISSN: 10987339     EISSN: 15328651     Source Type: Journal    
DOI: 10.1097/AAP.0b013e3182324d18     Document Type: Article

References (22)

1. Fernandez JG, Parodi E, Garcia P, et al. Clinical actions of subarachnoid sevoflurane administration in vivo: a study in dogs. Br J Anaesth. 2005;95:530-534. (Pubitemid 41418751)
2. Chai YF, Yang J, Liu J, et al. Epidural anaesthetic effect of the 8% emulsified isoflurane: a study in rabbits. Br J Anaesth. 2008;100:109-115. (Pubitemid 351773408)
3. Zhou C, Gan J, Liu J, Luo WJ, Zhang WS, Chai YF. The interaction between emulsified isoflurane and lidocaine is synergism in intravenous regional anesthesia in rats. Anesth Analg. 2011;113:245-250.
4. Li Z, Yang J, Liu J, et al. Reversible conduction block in isolated toad sciatic nerve by emulsified isoflurane. Anesth Analg. 2010;110:1024-1029.
5. Eger EI II, Raines DE, Shafer SL, Hemmings HC Jr, Sonner JM. Is a new paradigm needed to explain how inhaled anesthetics produce immobility? Anesth Analg. 2008;107:832-848.
6. Quasha AL, Eger EI II, Tinker JH. Determination and applications of MAC. Anesthesiology. 1980;53:315-334. (Pubitemid 10006760)
7. Haydon DA, Urban BW. The effects of some inhalation anaesthetics on the sodium current of the squid giant axon. J Physiol. 1983;341: 429-439. (Pubitemid 13028545)
8. Rehberg B, Xiao YH, Duch DS. Central nervous system sodium channels are significantly suppressed at clinical concentrations of volatile anesthetics. Anesthesiology. 1996;84:1223-1233. (Pubitemid 26145514)
9. Ouyang W, Wang G, Hemmings HC Jr. Isoflurane and propofol inhibit voltage-gated sodium channels in isolated rat neurohypophysial nerve terminals. Mol Pharmacol. 2003;64:373-381. (Pubitemid 36910001)
10. Ratnakumari L, Hemmings HC Jr. Inhibition of presynaptic sodium channels by halothane. Anesthesiology. 1998;88:1043-1054. (Pubitemid 28193332)
11. Westphalen RI, Hemmings HC Jr. Selective depression by general anesthetics of glutamate versus GABA release from isolated cortical nerve terminals. J Pharmacol Exp Ther. 2003;304:1188-1196. (Pubitemid 36254432)
12. Lingamaneni R, Birch ML, Hemmings HC Jr. Widespread inhibition of sodium channel-dependent glutamate release from isolated nerve terminals by isoflurane and propofol. Anesthesiology. 2001;95: 1460-1466. (Pubitemid 33126759)
13. Ouyang W, Herold KF, Hemmings HC Jr. Comparative effects of halogenated inhaled anesthetics on voltage-gated Na+ channel function. Anesthesiology. 2009;110:582-590.
14. Herold KF, Nau C, Ouyang W, Hemmings HC Jr. Isoflurane inhibits the tetrodotoxin-resistant voltage-gated sodium channel NaV1.8. Anesthesiology. 2009;111:591-599.
15. Zhang Y, Sharma M, Eger EI II, Laster MJ, Hemmings HC Jr, Harris RA. Intrathecal veratridine administration increases minimum alveolar concentration in rats. Anesth Analg. 2008;107:875-878.
16. Hemmings HC Jr. Sodium channels and the synaptic mechanisms of inhaled anaesthetics. Br J Anaesth. 2009;103:61-69.
17. Grasshoff C, Antkowiak B. Effects of isoflurane and enflurane on GABAA and glycine receptors contribute equally to depressant actions on spinal ventral horn neurones in rats. Br J Anaesth. 2006;97:687-694. (Pubitemid 44593865)
18. Stabernack C, Sonner JM, Laster M, et al. Spinal N-methyl-D-aspartate receptors may contribute to the immobilizing action of isoflurane. Anesth Analg. 2003;96:102-107. (Pubitemid 36042041)
19. Ishizaki K, Yoon DM, Yoshida N, Yamazaki M, Arai K, Fujita T. Intrathecal administration of N-methyl-D-aspartate receptor antagonist reduces the minimum alveolar anaesthetic concentration of isoflurane in rats. Br J Anaesth. 1995;75:636-638.
20. Ishizaki K, Yoshida N, Yoon DM, Yoon MH, Sudoh M, Fujita T. Intrathecally administered NMDA receptor antagonists reduce the MAC of isoflurane in rats. Can J Anesth. 1996;43:724-730. (Pubitemid 26291338)
21. Barter LS, Carstens EE, Jinks SL, Antognini JF. Rat dorsal horn nociceptive-specific neurons are more sensitive than wide dynamic range neurons to depression by immobilizing doses of volatile anesthetics: an effect partially reversed by the opoid receptor antagonist naloxone. Anesth Analg. 2009;109:641-647.
22. Rowley TJ, Daniel D, Flood P. The role of adrenergic and cholinergic transmission in volatile anesthetic-induced pain enhancement. Anesth Analg. 2005;100:991-995. (Pubitemid 40404201)