Chemotherapy in pregnancy

Clinical Obstetrics and Gynecology

Volumn 54, Issue 4, 2011, Pages 602-618

  Brewer, Molly ^a   Kueck, Angela ^a   Runowicz, Carolyn D ^a,b  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b FLORIDA INTERNATIONAL UNIVERSITY   (United States)

Author keywords

cancer; chemotherapy; pregnancy

Indexed keywords

ANTINEOPLASTIC AGENT; ASPARAGINASE; BLEOMYCIN; CARBOPLATIN; CARMUSTINE; CHLORAMBUCIL; CISPLATIN; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYTARABINE; DACARBAZINE; DAUNORUBICIN; DOCETAXEL; DOXORUBICIN; ETOPOSIDE; HYDROXYUREA; IDARUBICIN; METHOTREXATE; PACLITAXEL; PHOSPHORUS 32; PREDNISONE; RITUXIMAB; TAMOXIFEN; TRASTUZUMAB; VINBLASTINE; VINCRISTINE;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ACUTE LYMPHOCYTIC LEUKEMIA; ADD ON THERAPY; ADJUVANT THERAPY; ANEMIA; ARTICLE; BONE MARROW DEPRESSION; BONE MARROW SUPPRESSION; BONE METASTASIS; BRAIN ATROPHY; BRAIN VENTRICLE DILATATION; BREAST CANCER; BREAST DISCHARGE; BREAST FEEDING; CANCER CHEMOTHERAPY; CANCER GRADING; CANCER INCIDENCE; CANCER RECURRENCE; CANCER RISK; CHRONIC LYMPHATIC LEUKEMIA; CHRONIC MYELOID LEUKEMIA; CLEFT LIP; COLITIS; CREATININE BLOOD LEVEL; DISEASE FREE SURVIVAL; DRUG SAFETY; DRUG TOLERABILITY; DYSGERMINOMA; FEMALE GENITAL TRACT CANCER; FETUS DEATH; FETUS MALFORMATION; FETUS RISK; FETUS WASTAGE; GERM CELL TUMOR; GRANULOSA CELL TUMOR; HODGKIN DISEASE; HUMAN; HYDRAMNIOS; HYSTERECTOMY; INTRAUTERINE GROWTH RETARDATION; LARGE CELL LYMPHOMA; LEUKEMIA REMISSION; LEUKOPENIA; LIVER METASTASIS; LOW BIRTH WEIGHT; LUNG CANCER; LUNG METASTASIS; MANTLE CELL LYMPHOMA; MASTECTOMY; MICROPHTHALMIA; NEURAL TUBE DEFECT; NEUTROPENIA; NK T CELL LYMPHOMA; NONHODGKIN LYMPHOMA; NUCLEAR MAGNETIC RESONANCE IMAGING; OLIGOHYDRAMNIOS; OTOTOXICITY; OVARY CANCER; OVARY TERATOMA; OVERALL SURVIVAL; PANCYTOPENIA; PHOCOMELIA; PLACENTAL TRANSFER; PREGNANCY COMPLICATION; PREGNANCY TERMINATION; PREGNANT WOMAN; PREMATURE LABOR; PREMATURITY; PRENATAL DRUG EXPOSURE; PRENATAL GROWTH; PUERPERIUM; SECOND TRIMESTER PREGNANCY; SIDE EFFECT; SINGLE DRUG DOSE; SPONTANEOUS ABORTION; STILLBIRTH; T CELL LYMPHOMA; TERATOGENICITY; THIRD TRIMESTER PREGNANCY; TREATMENT DURATION; TREATMENT RESPONSE; UTERINE CERVIX CANCER;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BREAST FEEDING; BREAST NEOPLASMS; FEMALE; FETAL DEVELOPMENT; HEMATOLOGIC NEOPLASMS; HUMANS; OVARIAN NEOPLASMS; POSTPARTUM PERIOD; PREGNANCY; PREGNANCY COMPLICATIONS, NEOPLASTIC; PREGNANCY TRIMESTERS;

EID: 80055092055     PISSN: 00099201     EISSN: 15325520     Source Type: Journal    
DOI: 10.1097/GRF.0b013e318236e9f9     Document Type: Article

References (84)

1. Smith LH, Dalrymple JL, Leiserowitz GS, et al. Obstetrical deliveries associated with maternal malignancy in California, 1992 through 1997. Am J Obstet Gynecol. 2001;184:1504.
2. Daniilidis A, Giannoulis C, Sardeli C, et al. Pregnancy-associated breast cancer: a review analysis. Eur J Gynaecol Oncol. 2010;31:485-490.
3. Koren G, Lishner M. Pregnancy and commonly used drugs in hematology practice. Hematology Am Soc Hematol Educ Program. 2010;2010:160-165.
4. Sukumvanich P. Review of current treatment options for pregnancy-associated breast cancer. Clin Obstet Gynecol. 2011;54:164-172.
5. Cardonick E, Iacobucci A. Use of chemotherapy during human pregnancy. Lancet Oncol. 2004;5:283.
6. Leslie KK, Koil C, RayburnWF. Chemotherapeutic drugs in pregnancy. Obstet Gynecol Clin North Am. 2005;32:627.
7. Ebert U, Loffler H, Kirch W. Cytotoxic therapy and pregnancy. Pharmacol Ther. 1997;74:207.
8. Nicholson HO. Cytotoxic drugs in pregnancy Review of reported cases. J Obstet Gynaecol Br Commonw. 1968;75:307.
9. Abadi U, Koren G, Lishner M. Leukemia and lymphoma in pregnancy. Hematol Oncol Clin North Am. 2011;25:277-291.
10. Doll DC, Ringenberg QS, Yarbro JW. Management of cancer during pregnancy. Arch Intern Med. 1988;148:2058.
11. Theriault R, Hahn K. Management of breast cancer in pregnancy. Curr Oncol Rep. 2007;9:17.
12. Boulay R, Podczaski E. Ovarian cancer complicating pregnancy. Obstet Gynecol Clin North Am. 1998;25:385.
13. Andersson TM, Johansson AL, Hsieh CC, et al. Increasing incidence of pregnancy-associated breast cancer in Sweden. Obstet Gynecol. 2009;114:568-572.
14. Buré L, Azoulay L, Benjamin A. Abenhaim, Pregnancy-associated breast cancer: a review for the obstetrical care provider. JOGC. 2011;33:330-337.
15. Azim HA Jr, Del Mastro L, Scarfone G, et al. Treatment of breast cancer during pregnancy: regimen selection, pregnancy monitoring and more. Breast. 2011;20: 1-6. Epub 2010 Dec 15.
16. Middleton LP, Amin M, Gwyn K, et al. Breast carcinoma in pregnant women: assessment of clinicopathologic and immunohistochemical features. Cancer. 2003;98:1055-1060. (Pubitemid 37022108)
17. Johannsson O, Loman N, Borg A, et al. Pregnancy-associated breast cancer in BRCA1 and BRCA2 germline mutation carriers. Lancet. 1998;352:1359-1360. (Pubitemid 28510925)
18. Loibl S, von Minckwitz G, Gwyn K, et al. Breast carcinoma during pregnancy. Cancer. 2006;106:237-246.
19. Litton JK, Theriault RL. Breast cancer and pregnancy: current concepts in diagnosis and treatment. Oncologist. 2010;15: 1238-1247.
20. Cardonick E, Dougherty R, Grana G, et al. Breast cancer during pregnancy: Maternal and fetal outcomes. Cancer J. 2010;16:76-82.
21. Avilés A, Neri N. Hematologic malignancies and pregnancy: A final report of 84 children who received chemotherapy in utero. Clin Lymphoma. 2001;2:173-177. (Pubitemid 34092723)
22. Avilés A, Neri N, Nambo MJ. Longterm evaluation of cardiac function in children who received anthracyclines during pregnancy. Ann Oncol. 2006;17: 286-288. (Pubitemid 43160119)
23. Zoccarato G, Romagnolo C, Ghiotto C, et al. High frequency of premature births in concomitant pregnancy and cancer. J Clin Oncol abstract. 2010;28:Abstract 12020.
24. Azim HA, Pavlidis N, Peccatori FA. Treatment of the pregnant mother with cancer: a systematic review on the use of cytotoxic, endocrine, targeted agents and immunotherapy during pregnancy Part II: hematological tumors. Cancer Treat Rev. 2010;36:110-121.
25. Azim HA Jr, Peccatori FA. Managing cancer during pregnancy: what evidence do we have? Pol Arch Med Wewn. 2011; 121(1-2):29-34.
26. Pereg D, Koren G, LishnerM. The treatment of Hodgkin's and non-Hodgkin's lymphoma in pregnancy. Hematologica. 2007;92:1230-1237. (Pubitemid 350144182)
27. Abadi U, Koren G, Lishner M. Hematol. Leukemia and lymphoma in pregnancy. Oncol Clin N Am. 2011;25:277-291.
28. Aviles A, Niz J. Long-term follow-up of children born to mothers with acute leukemia during pregnancy. Med Ped Oncol. 1988;16:3-6. (Pubitemid 18093948)
29. Azim HA Jr, Peccatori FA, Pavlidis N. Lung cancer in the pregnant woman: to treat or not to treat, that is the question. Lung Cancer. 2010;67:251-256.
30. www.cancer.gov/cancertopics/factsheet/risk/brca. Accessed January 29, 2009.
31. Leiserowitz GS, Xing G, Cress R, et al. Adnexal masses in pregnancy: how often are they malignant? Gynecol Oncol. 2006;101:315.
32. Schmeler KM, Mayo-Smith WW, Peipert JF, et al. Adnexal masses in pregnancy: surgery compared with observation. Obstet Gynecol. 2005;105:1098.
33. Palmer J, Vatish M, Tidy J. Epithelial ovarian cancer in pregnancy: a review of the literature. BJOG. 2009;116:480.
34. Sayar H, Lhomme C, Verschraegen CF. Malignant adnexal masses in pregnancy. Obstet Gynecol Clin North Am. 2005;32: 569-593. (Pubitemid 41718952)
35. Mooney J, Silva E, Tornos C, et al. Unusual features of serous neoplasms of low malignant potential during pregnancy. Gynecol Oncol. 1997;65:30.
36. Bakri YN, Ezzat A, Akhtar, et al. Malignant germ cell tumors of the ovary: pregnancy considerations. Eur J Obstet Gynecol Reprod Biol. 2000;90:87.
37. Young RH, Dudley AG, Scully RE. Granulosa cell, Sertoli-Leydig cell, and unclassified sex cord-stromal tumors associated with pregnancy: a clinicopathological analysis of thirty-six cases. Gynecol Oncol. 1984;18:181.
38. Sarandakou A, Protonotariou E, Rizos D. Tumor markers in biological fluids associated with pregnancy. Crit Rev Clin Lab Sci. 2007;44:151.
39. Frederiksen MC, Casanova L, Schink JC. An elevated maternal serum alpha-fetoprotein leading to the diagnosis of an immature teratoma. Int J Gynaecol Obstet. 1991;35:343.
40. Nawa A, Obata N, Kikkawa F, et al. Prognostic factors of patients with yolk sac tumors of the ovary. Am J Obstet Gynecol. 2001;184:1182.
41. Schumer ST, Cannistra SA. Granulosa cell tumor of the ovary. J Clin Oncol. 2003;21:1180.
42. Luisi S, Florio P, Reis FM, et al. Inhibins in female and male reproductive physiology: role in gametogenesis, conception, implantation and early pregnancy. Hum Reprod Update. 2005; 11:123.
43. Leiserowitz GS, Xing G, Cress R, et al. Adnexal masses in pregnancy: how often are they malignant? Gynecol Oncol. 2006;101:315.
44. Schmeler KM,Mayo-Smith WW, Peipert JF, et al. Adnexal masses in pregnancy: surgery compared with observation. Obstet Gynecol. 2005;105:1098.
45. Leiserowitz GS. Managing ovarian masses during pregnancy. Obstet Gynecol Surv. 2006;61:463.
46. Berretta R, Rolla M, Ceccaroni M, et al. Nardelli Laparoscopic management of gynaecological cancer in pregnancy. J Obstet Gynaecol. 2010;30:319-321.
47. Gershenson DM, Silva EG, Levy L, et al. Ovarian serous borderline tumors with invasive peritoneal implants. Cancer. 1998;82:1096.
48. Mendez LE, Mueller A, Salom E, et al. Paclitaxel and carboplatin chemotherapy administered during pregnancy for advanced epithelial ovarian cancer. Obstet Gynecol. 2003;102:1200.
49. Picone O, Lhomme C, Tournaire M, et al. Preservation of pregnancy in a patient with a stage IIIB ovarian epithelial carcinoma diagnosed at 22 weeks of gestation and treated with initial chemotherapy: case report and literature review. Gynecol Oncol. 2004;94:600.
50. Sood AK, Shahin MS, Sorosky JI. Paclitaxel and platinum chemotherapy for ovarian carcinoma during pregnancy. Gynecol Oncol. 2001;83:599.
51. Ferrandina G, Distefano M, Testa A, et al. Management of an advanced ovarian cancer at 15 weeks of gestation: case report and literature review. Gynecol Oncol. 2005;97:693.
52. Tomlinson MW, Treadwell MC, Deppe G. Platinum based chemotherapy to treat recurrent Sertoli-Leydig cell ovarian carcinoma during pregnancy. Eur J Gynaecol Oncol. 1997;18:44.
53. Sayedur Rahman M, Al-Sibai MH, Rahman J, et al. Ovarian carcinoma associated with pregnancy A review of 9 cases. Acta Obstet Gynecol Scand. 2002;81:260.
54. Huang HP, Fang CN, Kan YY. Chemotherapy for ovarian mucinous cystadenocarcinoma during pregnancy: a case report. Eur J Gynaecol Oncol. 2004; 25:635.
55. Raffles A, Williams J, Costeloe K, et al. Transplacental effects of maternal cancer chemotherapy. Case report. Br J Obstet Gynaecol. 1989;96:1099.
56. Henderson CE, Elia G, Garfinkel D, et al. Platinum chemotherapy during pregnancy for serous cystadenocarcinoma of the ovary. Gynecol Oncol. 1993;49:92.
57. Modares Gilani M, Karimi Zarchi M, Behtash N, et al. Preservation of pregnancy in a patient with advanced ovarian cancer at 20 weeks of gestation: case report and literature review. Int J Gynecol Cancer. 2007;17:1140.
58. Tabata T, Nishiura K, Tanida K, et al. Carboplatin chemotherapy in a pregnant patient with undifferentiated ovarian carcinoma: case report and review of the literature. Int J Gynecol Cancer. 2008;18:181.
59. Hubalek M, Smekal-Schindelwig C, Zeimet AG, et al. Chemotherapeutic treatment of a pregnant patient with ovarian dysgerminoma. Arch Gynecol Obstet. 2007;276:179.
60. Mir O, Berveiller P, Ropert S, et al. Use of platinum derivatives during pregnancy. Cancer. 2008;113:3069.
61. Doi D, Boh Y, Konishi H, et al. Combined chemotherapy with paclitaxel and carboplatin for mucinous cystadenocarcinoma of the ovary during pregnancy. Arch Gynecol Obstet. 2009;280: 633-636.
62. Boulay R, Podczaski E. Ovarian cancer complicating pregnancy. Obstet Gynecol Clin N Am. 1998;25:385.
63. Loibl S, von Minckwitz G, Gwyn K, et al. Breast carcinoma during pregnancy: international recommendations from an expert meeting. Cancer. 2006;106:237.
64. ICON2: randomization trial of singleagent carboplatin against three-drug combination ofCAP(cyclophosphamide, doxorubicin, and cisplatin) in women with ovarian cancer. ICON Collaborators. International Collaborative Ovarian Neoplasm Study. Lancet. 1998;352: 1571-1576.
65. The International Collaborative Ovarian Neoplasm (ICON) groupPaclitaxel plus carboplatin versus standard chemotehrapy with either single agent carboplatin or cyclophosphamide, doxorubicin, and cisplatin in women with ovarian cancer: the ICON3 randomised trial. Lancet. 2002; 360:505-515.
66. Colombo N, Pecorelli S. What have we learned from ICON1 and ACTION? Int J Gynecol Cancer. 2003;13 (SUPPL. 2): 140.
67. Bolis G, Colombo N, Pecorelli S, et al. Adjuvant treatment for early epithelial ovarian cancer: results of two randomized clinical trials comparing cisplatin to no further treatment or chromic phosphate (32 P) G.I.C.O.C.: Gruppo Interregionale Collaborativo in Ginecologia Oncologica. Ann Oncol. 1995;6:887.
68. Muggia FM, Braly PS, Brady MF, et al. Phase III randomized study of cisplatin versus paclitaxel versus cisplatin and paclitaxel in patients with suboptimal stage III or IV ovarian cancer: a gynecologic oncology group study. J Clin Oncol. 2000;18:106.
69. Muggia FM. Sequential single agents as first-line chemotherapy for ovarian cancer: a strategy derived from the results of GOG-132. Int J Gynecol Cancer. 2003;13 (SUPPL. 2):156.
70. Armstrong DK, Bundy B, Wenzel L, et al. Intraperitoneal cisplatin and paclitaxel in ovarian cancer. N Engl J Med. 2006; 354:34.
71. Jaaback K, Johnson N. Intraperitoneal chemotherapy for the initial management of primary epithelial ovarian cancer. Cochrane Database Syst Rev 2006 CD005340.
72. Cardonick E, Iacobucci A. Use of chemotherapy during human pregnancy. Lancet Oncol. 2004;5:283.
73. Leslie KK, Koil C, Rayburn WF. Chemotherapeutic drugs in pregnancy. Obstet Gynecol Clin North Am. 2005; 32:627.
74. Han JY, Nava-Ocampo AA, Kim TJ, et al. Pregnancy outcome after prenatal exposure to bleomycin, etoposide and cisplatin for malignant ovarian germ cell tumors: report of 2 cases. Reprod Toxicol. 2005;19:557.
75. Elit L, Bocking A, Kenyon C, et al. An endodermal sinus tumor diagnosed in pregnancy: case report and review of the literature. Gynecol Oncol. 1999;72:123.
76. Motegi M, Takakura S, Takano H, et al. Adjuvant chemotherapy in a pregnant woman with endodermal sinus tumor of the ovary. Obstet Gynecol. 2007;109:537.
77. Shimizu Y, Komiyama S, Kobayashi T, et al. Successful management of endodermal sinus tumor of the ovary associated with pregnancy. Gynecol Oncol. 2003; 88:447.
78. Aoki Y, Higashino M, Ishii S, et al. Yolk sac tumor of the ovary during pregnancy: a case report. Gynecol Oncol. 2005; 99:497.
79. Rajendran S, Hollingworth J, Scudamore I. Endodermal sinus tumour of the ovary in pregnancy. Eur J Gynaecol Oncol. 1999;20:272.
80. Zhao XY, Huang HF, Lian LJ, et al. Ovarian cancer in pregnancy: a clinicopathologic analysis of 22 cases and review of the literature. Int J Gynecol Cancer. 2006;16:8.
81. Stensheim H, Moller B, van Dijk T, et al. Cause-specific survival for women diagnosed with cancer during pregnancy or lactation: a registry-based cohort study. J Clin Oncol. 2009;27:45.
82. Egorin MJ, Bachur NR. Transfer of drugs and other chemicals into human milk. Pediatrics 2001; 108:776.
83. Egan PC, Costanza ME, Dodion P, et al. Doxorubicin and cisplatin excretion into humanmilk.CancerTreatRep. 1985;69:1387.
84. Gambino A, Gorio A. Carrara L, et al. Cancer in pregnancy: maternal and fetal implications on decision-making. Eur J Gynaecol Oncol. 2011;32:40-45.