Epithelial ovarian cancer in pregnancy: A review of the literature

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 116, Issue 4, 2009, Pages 480-491

  Palmer, J ^a   Vatish, M ^b,c   Tidy, J ^a  

^a ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

^c UNIVERSITY HOSPITALS COVENTRY AND WARWICKSHIRE NHS TRUST   (United Kingdom)

Author keywords

Chemotherapy; Epithelial ovarian carcinoma; Ovarian carcinoma; Pregnancy

Indexed keywords

CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; EPIRUBICIN; PACLITAXEL; PLATINUM; TOPOTECAN;

ABSENCE OF SIDE EFFECTS; ANAPHYLAXIS; BODY WEIGHT; BONE MARROW SUPPRESSION; CANCER DIAGNOSIS; CANCER INCIDENCE; CANCER STAGING; CANCER SURGERY; EPITHELIUM CELL; FERTILITY; FOLLOW UP; HUMAN; IMMUNE COMPLEX NEPHRITIS; LEARNING; MEMORY; MOTOR ACTIVITY; MULTIPLE CYCLE TREATMENT; NEUROTOXICITY; NONHUMAN; OUTCOME ASSESSMENT; OVARY CANCER; PRACTICE GUIDELINE; PREGNANCY; PRIORITY JOURNAL; REVIEW; SIDE EFFECT;

ADULT; ANTINEOPLASTIC AGENTS; FEMALE; HUMANS; MATERNAL AGE; MIDDLE AGED; OVARIAN NEOPLASMS; PREGNANCY; PREGNANCY COMPLICATIONS, NEOPLASTIC; PREGNANCY OUTCOME; YOUNG ADULT;

EID: 60449118711     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.2008.02089.x     Document Type: Review

References (76)

1. Marino T, Craigo SD. Managing adnexal masses in pregnancy. Contemp Obstet Gynecol 2000 45 : 130 43.
2. Leiserowitz GS, Xing G, Cress R, Brahmbhatt B, Dalrymple JL, Smith LH. Adnexal masses in pregnancy: how often are they malignant? Gynecol Oncol 2006 101 : 315 21.
3. Dessole S, Capobianco G, Milia L, Cherchi PL. Giant ovarian tumor complicating late pregnancy: a case report. Acta Obstet Gynecol Scand 2001 80 : 665 7.
4. Otton G, Higgins S, Phillips KA, Quinn M. A case of early-stage epithelial ovarian cancer in pregnancy. Int J Gynecol Cancer 2001 11 : 413 17.
5. Machado F, Vegas C, Leon J, Perez A, Sanchez R, Parrilla JJ, et al. Ovarian cancer during pregnancy: analysis of 15 cases. Gynecol Oncol 2007 105 : 446 50.
6. Jubb ED. Primary ovarian cancer in pregnancy. Am J Obstet Gynecol 1963 85 : 345 54.
7. Matsuyama T, Tsukamoto N, Matsukuma K, Kamura T, Kaku T, Saito T. Malignant ovarian tumors associated with pregnancy: report of six cases. Int J Gynaecol Obstet 1989 28 : 61 6.
8. Oheler MK, Wain GV, Brand A. Gynaecological malignancies in pregnancy: a review. Aust N Z J Obstet Gynaecol 2003 43 : 414 20.
9. Zanotti KS, Belinson JL, Kennedy AW. Treatment of gynaecologic cancers in pregnancy. Semin Oncol 2000 27 : 686 98.
10. Modares Gilani M, Karimi Zarchi M, Behtash N, Ghaemmaghami F, Mousavi AS, Behnamfar F. Preservation of pregnancy in a patient with advanced ovarian cancer at 20 weeks of gestation: case report and literature review. Int J Gynecol Cancer 2007 17 : 1140 3.
11. Betson JR, Golden ML. Primary carcinoma of the ovary coexisting with pregnancy. Obstet Gynecol 1958 12 : 589 95.
12. Zhao XY, Huang HF, Lian LJ, Lang JH. Ovarian cancer in pregnancy: a clinicopathologic analysis of 22 cases and review of the literature. Int J Gynecol Cancer 2006 16 : 8 15.
13. Sayedur RM, Al-Sibai MH, Rahman J, Al-Suleiman SA, El-Yahia AR, Al-Mulhim AA, et al. Ovarian carcinoma associated with pregnancy. A review of 9 cases. Acta Obstet Gynecol Scand 2002 81 : 260 4.
14. Behtash N, Zarchi MK, Gilani MM, Ghaemmaghami F, Mousavi A, Ghotbizadeh F. Ovarian carcinoma associated with pregnancy: a clinicopathologic analysis of 23 cases and review of the literature. BMC Pregnancy Childbirth 2008 8 : 1 7.
15. Copeland LJ, London MB. Malignant disease in pregnancy. In : Gabbe SG, Niebyl JR, Simpson JL, editors. Obstetrics, Normal and Problem Pregnancies, 3rd edn. New York, NY : Churchill Livingstone 1996. pp. 1155 81.
16. Partridge EE, Phillips JL, Menck HR. The National Cancer Database report on ovarian cancer treatment in United States hospitals. Cancer 1996 78 : 2236 46.
17. Sayar H, Lhomme C, Verschraegen CF. Malignant adnexal masses in pregnancy. Obstet Gynecol Clin North Am 2005 32 : 569 93.
18. Chung A, Birnbaum SJ. Ovarian cancer associated with pregnancy. Obstet Gynecol 1973 41 : 211 14.
19. Cruickshank SH, McNellis TM, Wise HD. Mucinous cystadenocarcinoma of the ovary associated with pregnancy. Mo Med 1982 79 : 695 703.
20. van Dessel T, Hameeteman TM, Wagenaar SS. Mucinous cystadenocarcinoma in pregnancy. Case report. Br J Obstet Gynaecol 1988 95 : 527 9.
21. Malfetano JH, Goldkrand JW. Cis-platinum combination chemotherapy during pregnancy for advanced epithelial ovarian carcinoma. Obstet Gynecol 1990 75 : 545 7.
22. Beischer NA, Buttery BW, Fortune DW, Macafee CAJ. Growth and malignancy of ovarian tumours in pregnancy. Aust N Z J Obstet Gynaecol 1971 11 : 208 20.
23. Novak ER, Lambrou CD, Woodruff JD. Ovarian tumours in pregnancy. An ovarian tumour registry review. Obstet Gynecol 1975 46 : 401 6.
24. Age of mother, 1961 onwards, England and Wales. Health Statistics Quarterly, 34. UK : Office of National Statistics, 2007.
25. Leslie KK. Chemotherapy and pregnancy. Clin Obstet Gynecol 2002 45 : 153 64.
26. Ferrandina G, Distefano M, Testa A, De Vincenzo R, Scambia G. Management of advanced ovarian carcinoma at 15 weeks of gestation: case report and literature review. Gynecol Oncol 2005 97 : 693 6.
27. Méndez LE, Mueller A, Salom E, González-Quintero VH. Paclitaxel and carboplatin chemotherapy administered during pregnancy for advanced epithelial ovarian cancer. Obstet Gynecol 2003 102 : 1200 2.
28. Dgani R, Shoham Z, Atar E, Zosmer A, Lancet M. Ovarian carcinoma during pregnancy: a study of 23 cases in Israel between the years 1960 and 1984. Gynecol Oncol 1989 33 : 326 31.
29. Ahram J, Lakoff K, Miller R. Serous cystadenocarcinoma as incidental finding during a repeat cesarean section. Am J Obstet Gynecol 1985 153 : 78 9.
30. Patsner B, Mann WJ Jr., Chumas J. Primary invasive ovarian adenocarcinoma with brain and placental metastases: a case report. Gynecol Oncol 1989 33 : 112 15.
31. Altaras M, Rosen D, Shapira J, Cohen I, Bernheim J, Ravid M. Advanced primary ovarian carcinoma in pregnancy. Am J Obstet Gynecol 1989 160 : 1210 1.
32. King LA, Nevin PC, Williams PP, Carson LF. Treatment of advanced epithelial ovarian carcinoma in pregnancy with cisplatin-based chemotherapy. Gynecol Oncol 1991 41 : 78 80.
33. Henderson CE, Elia G, Garfinkel D, Poirier MC, Shamkhani H, Runowicz CD. Platinum chemotherapy during pregnancy for serous cystadenocarcinoma of the ovary. Gynecol Oncol 1993 49 : 92 4.
34. Sood AK, Shahin MS, Sorosky JI. Paclitaxel and platinum chemotherapy for ovarian carcinoma during pregnancy. Gynecol Oncol 2001 83 : 599 600.
35. Picone O, Lhomme C, Tournaire M, Pautier P, Camatte S, Vacher-Lavenue MC, et al. Preservation of pregnancy in a patient with a stage IIIb ovarian epithelial carcinoma diagnosed at 22 weeks gestation and treated with initial chemotherapy: case report and literature review. Gynecol Oncol 2004 94 : 600 4.
36. Huang HP, Fang CN, Kan YY. Chemotherapy for ovarian mucinous cystadenocarcinoma during pregnancy: a case report. Eur J Gynaecol Oncol 2004 25 : 635 6.
37. Raghunath RG, Shashi RR, Vijaykumar MA. A case of pregnancy with epithelial ovarian carcinoma. J Obstet Gynecol India 2006 56 : 446 8.
38. Mantovani G, Gramignano G, Mais V, Melis GB, Parodo G, Carrucciu GM. Use of chemotherapy for ovarian cancer during human pregnancy: case report and review of the literature. Eur J Obstet Gynecol Reprod Biol 2007 131 : 235 45.
39. Ishioka SI, Hayashi T, Endo T, Baba T, Honma H, Saito T. Advanced epithelial ovarian carcinoma during pregnancy. Int J Clin Oncol 2007 12 Epub ahead of print T, Nishiura K, Tanida K, Kondo E, Okugawa T, Sagawa N. Carboplatin chemotherapy in a pregnant patient with undifferentiated ovarian carcinoma: case report and review of the literature. Int J Gynecol Cancer 2008 18 : 181 4.
40. Lerner JP, Timor-Tritsch IE, Federman A, Abramovich G. Transvaginal ultrasonographic characterization of ovarian masses with an improved, weighted scoring system. Am J Obstet Gynecol 1994 170 : 81 5.
41. Katz VL, Watson WJ, Hansen WF, Washington JL. Massive ovarian tumour complicating pregnancy. J Reprod Med 1993 38 : 907 10.
42. Van Oppen ACC, Holm JP, Trimbos JB, Kazzas BA. Conservative management of an ovarian cyst in late pregnancy. Int J Gynaecol Obstet 1990 31 : 371 5.
43. Whitecar MP, Turner S, Higby MK. Adnexal masses in pregnancy: a review of 130 cases undergoing surgical management. Am J Obstet Gynecol 1999 18 : 19 24.
44. Platek DN, Henderson CE, Goldberg GL. The management of a persistent adnexal mass in pregnancy. Am J Obstet Gynecol 1995 173 : 1236 40.
45. Lee GSR, Hur SY, Shin JC, Kim SP, Kim SJ. Elective vs conservative management of ovarian tumours in pregnancy. Int J Gynecol Obstet 2004 85 : 250 4.
46. Morice P, Camatte S, Pautier P, Castaigne V, Germann N, Pomel C, et al. Gynecological cancers and pregnancy: the point of view of the oncology gynaecologist. Bull Cancer 2002 89 : 765 71.
47. Lowe SA. Diagnostic radiography in pregnancy: risks and reality. Aust N Z J Obstet Gynaecol 2004 44 : 191 6.
48. McCollough CH, Schueler BA, Atwell TD, Braun NN, Regner DM, Brown DL, et al. Radiation exposure and pregnancy: when should we be concerned? Radiographics 2007 27 : 909 17 discussion 917-18.
49. Smits AK, Paladine HL, Judkins DZ, Huber T. Clinical inquiries. What are the risks to the fetus associated with diagnostic radiation exposure during pregnancy? J Fam Pract 2006 55 : 441 2, 444.
50. Shellock FG, Kanal E. Policies, guidelines, and recommendations for MR imaging safety and patient management. SMRI Safety Committee. J Magn Reson Imaging 1991 1 : 97 101.
51. American College of Obstetricians and Gynecologists. Guidelines for diagnostic imaging during pregnancy. ACOG Committee Opinion No. 299. Obstet Gynecol 2004 104 : 647 51.
52. U.S. Food and Drug Administration. Guidance for Content and Review of a Magnetic Resonance Diagnostic Device 510 (k) Application. Washington D.C. 1988.
53. Runge VM. Safety of approved MR contrast media for intravenous injection. J Magn Reson Imaging 2000 12 : 205 13.
54. Kobayashi F, Sagawa N, Nakamura K, Nonogaki M, Ban C, Fujii S, et al. Mechanism and clinical significance of elevated Ca125 levels in the sera of pregnant women. Am J Obstet Gynecol 1989 160 : 563 6.
55. Creasman WT, Rutledge F, Smith JP. Carcinoma of the ovary associated with pregnancy. Obstet Gynecol 1971 38 : 111 16.
56. Niloff JM, Knapp RC, Schaetzl E, Reynolds C, Bast RC Jr. Ca125 antigen levels in obstetric and gynaecologic patients. Obstet Gynecol 1984 64 : 703 7.
57. Halila H, Stenman U, Seppala M. Ovarian cancer antigen Ca125 levels in pelvic inflammatory disease and pregnancy. Cancer 1986 57 : 1327 9.
58. Haga Y, Sakamoto K, Egami H, Yoshimura R, Akagi M. Elevation of serum Ca125 values in healthy individuals and pregnant women. Am J Med Sci 1986 292 : 25 9.
59. Terek MC, Akercan F, Sendag F, et al. Management of ovarian tumours in pregnancy: description of a case and review of the literature. Artemis 2004 5 : 76 9.
60. Cancer Research UK. Ovarian Cancer Statistics for the UK (online). London : Cancer Research UK. 2005 http://info.cancerresearchuk.org/cancerstats/ types%20/ovary/?a5441 Accessed 2 June 2008.
61. Royal College of Obstetricians and Gynaecologists. Antenatal Corticosteroids to Prevent Respiratory Distress Syndrome. RCOG Guideline No 7. London : RCOG, 2004.
62. Hunt MG, Martin JN Jr., Martin RW, Meeks GR, Wiser WL, Morrison JC. Perinatal aspects of abdominal surgery for nonobstetric disease. Am J Perinatol 1989 6 : 412 17.
63. Allen JR, Helling TS, Langenfeld M. Intra abdominal surgery during pregnancy. Am J Surg 1989 158 : 567 9.
64. Agarwal N, Parul P, Kriplani A, Bhatla N, Gupta A. Management and outcome of pregnancies complicated with adnexal masses. Arch Gynecol Obstet 2003 267 : 148 52.
65. Grendys EC, Barnes WA. Ovarian cancer in pregnancy. Surg Clin North Am 1995 75 : 1 14.
66. Ghaemmaghami F, Hasanzadeh M. Good fetal outcome of pregnancies with gynaecologic cancer conditions: cases and literature review. Int J Gynecol Cancer 2006 16 : 1 6.
67. Ozols RF, Bundy BN, Greer BE, Fowler JM, Clarke-Pearson D, Burger RA, et al. Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: a Gynecologic Oncology Group study. J Clin Oncol 2003 21 : 3194 200.
68. Kai S, Kohmura H, Ishikawa K, Makihara Y, Ohta S, Kawano S, et al. Teratogenic effects of carboplatin, an oncostatic drug, administered during the early organogenetic period in rats. J Toxicol Sci 1989 14 : 115 30.
69. Kai S, Kohmura H, Ishikawa K, Takeuchi Y, Ohta S, Kuroyanagi K, et al. Reproduction studies of carboplatin (II) - intravenous administration to rats during the period of fetal organogenesis. J Toxicol Sci 1988 13 : 35 61.
70. Kai S, Kohmura H, Hiraiwa E, Koizumi S, Ishikawa K, Kawano S, et al. Reproductive and developmental toxicity studies of paclitaxel. (III) - intravenous administration to rats during the perinatal and lactation periods. J Toxicol Sci 1994 19 : 93 111.
71. Williams SF, Bitran JD. Cancer and pregnancy. Clin Perinatol 1985 12 : 609 23.
72. Hubalek M, Smekal-Schindelwig C, Zeimet AG, Sergi C, Brezinka C, Mueller-Holzner E, et al. Chemotherapeutic treatment of a pregnant patient with ovarian dysgerminoma. Arch Gynecol Obstet 2007 276 : 179 83.
73. Karlen JR, Akbari A, Cook WA. Dysgerminoma associated with pregnancy. Obstet Gynecol 1979 53 : 330 5.
74. Bakri YN, Ezzat A, Akhtar M, Dohami H, Zahrani A. Malignant germ cell tumours of the ovary. Pregnancy considerations. Eur J Obstet Gynecol Reprod Biol 2000 90 : 87 91.
75. Zemlekis D, Lishner M, Degendorfer P, Panzarella T, Sutcliffe SB, Koren G. Fetal outcome after in utero exposure to cancer chemotherapy. Arch Intern Med 1992 152 : 573 6.
76. Doll DC, Ringenberg QS, Yarbro JW. Antineoplastic agents and pregnancy. Semin Oncol 1989 16 : 337 46.