HCCS1-armed, quadruple-regulated oncolytic adenovirus specific for liver cancer as a cancer targeting gene-viro-therapy strategy

Molecular Cancer

Volumn 10, Issue , 2011, Pages

  Xu, Hai Neng ^a   Huang, Wei Dan ^a   Cai, Ying ^a   Ding, Miao ^a   Gu, Jin Fa ^a   Wei, Na ^a   Sun, Lan Ying ^a   Cao, Xin ^a   Li, Hua Guang ^a   Zhang, Kang Jian ^a   Liu, Xin Ran ^a   Liu, Xin Yuan ^a,b  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b ZHEJIANG SCI TECH UNIVERSITY   (China)

Author keywords

Hccs1; Liver cancer; Mitochondrial apoptosis pathway; Quadruple regulated adenovirus

Indexed keywords

GENE PRODUCT; ONCOLYTIC ADENOVIRUS; SURVIVIN; E1A PROTEIN; E1B PROTEIN; ONCOLYTIC VIRUS; VESICULAR TRANSPORT PROTEIN; VPS53 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER GENE THERAPY; CANCER INHIBITION; CELL SPECIFICITY; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DRUG EFFICACY; GENE CASSETTE; GENE DELETION; GENE EXPRESSION; GENE TARGETING; HCCS 1 GENE; HUMAN; HUMAN CELL; LIVER CANCER; NONHUMAN; PROMOTER REGION; SAFETY; TUMOR SUPPRESSOR GENE; TUMOR XENOGRAFT; ADENOVIRUS; ANIMAL; BAGG ALBINO MOUSE; CELL STRAIN HEK293; DRUG SCREENING; GENE VECTOR; GENETICS; LIVER TUMOR; MALE; METABOLISM; METHODOLOGY; MOUSE; NUDE MOUSE; ONCOLYTIC VIROTHERAPY; PHYSIOLOGY; TUMOR CELL LINE;

ADENOVIRIDAE; MUS MUSCULUS;

ADENOVIRIDAE; ADENOVIRUS E1A PROTEINS; ADENOVIRUS E1B PROTEINS; ANIMALS; APOPTOSIS; CELL LINE, TUMOR; GENES, TUMOR SUPPRESSOR; GENETIC VECTORS; HEK293 CELLS; HUMANS; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; ONCOLYTIC VIROTHERAPY; ONCOLYTIC VIRUSES; VESICULAR TRANSPORT PROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 80055060673     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-10-133     Document Type: Article

References (30)

1. Zhu AX. Systemic therapy of advanced hepatocellular carcinoma: how hopeful should we be?. Oncologist 2006, 11:790-800. 10.1634/theoncologist.11-7-790, 16880238.
2. Lau WY, Lai EC. Hepatocellular carcinoma: current management and recent advances. Hepatobiliary Pancreat Dis Int 2008, 7:237-257.
3. Liu XY. A New Anticancer Strategy-- Gene-Viro-Therapy of Cancer. Chin J Cancer Biother 2001, 8:1.
4. Zhang ZL, Zou WG, Luo CX, Li BH, Wang JH, Sun LY, Qian QJ, Liu XY. An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy. Cell Res 2003, 13:481-489. 10.1038/sj.cr.7290191, 14728805.
5. Pei Z, Chu L, Zou W, Zhang Z, Qiu S, Qi R, Gu J, Qian C, Liu X. An oncolytic adenoviral vector of Smac increases antitumor activity of TRAIL against HCC in human cells and in mice. Hepatology 2004, 39:1371-1381. 10.1002/hep.20203, 15122766.
6. Zhang Y, Gu J, Zhao L, He L, Qian W, Wang J, Wang Y, Qian Q, Qian C, Wu J, Liu XY. Complete elimination of colorectal tumor xenograft by combined manganese superoxide dismutase with tumor necrosis factor-related apoptosis-inducing ligand gene virotherapy. Cancer Res 2006, 66:4291-4298. 10.1158/0008-5472.CAN-05-1834, 16618754.
7. Liu XY, Qiu SB, Zou WG, Pei ZF, Gu JF, Luo CX, Ruan HM, Chen Y, Qi YP, Qian C. Effective gene-virotherapy for complete eradication of tumor mediated by the combination of hTRAIL (TNFSF10) and plasminogen k5. Mol Ther 2005, 11:531-541. 10.1016/j.ymthe.2004.12.003, 15771956.
8. Liu XY, Pestka S, Shi YF. Recent Advance in Cancer Research and Therapy. Amsterdam, Netherlands: Elsevier Press, .
9. Li B, Liu X, Fan J, Qi R, Bo L, Gu J, Qian Q, Qian C. A survivin-mediated oncolytic adenovirus induces non-apoptotic cell death in lung cancer cells and shows antitumoral potential in vivo. J Gene Med 2006, 8:1232-1242. 10.1002/jgm.953, 16900558.
10. Gomez-Manzano C, Balague C, Alemany R, Lemoine MG, Mitlianga P, Jiang H, Khan A, Alonso M, Lang FF, Conrad CA, et al. A novel E1A-E1B mutant adenovirus induces glioma regression in vivo. Oncogene 2004, 23:1821-1828. 10.1038/sj.onc.1207321, 15014451.
11. Fueyo J, Gomez-Manzano C, Alemany R, Lee PS, McDonnell TJ, Mitlianga P, Shi YX, Levin VA, Yung WK, Kyritsis AP. A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo. Oncogene 2000, 19:2-12. 10.1038/sj.onc.1203251, 10644974.
12. Bischoff JR, Kirn DH, Williams A, Heise C, Horn S, Muna M, Ng L, Nye JA, Sampson-Johannes A, Fattaey A, McCormick F. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science 1996, 274:373-376. 10.1126/science.274.5286.373, 8832876.
13. O'Shea CC, Johnson L, Bagus B, Choi S, Nicholas C, Shen A, Boyle L, Pandey K, Soria C, Kunich J, et al. Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity. Cancer Cell 2004, 6:611-623. 10.1016/j.ccr.2004.11.012, 15607965.
14. O'Shea CC, Soria C, Bagus B, McCormick F. Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy. Cancer Cell 2005, 8:61-74. 10.1016/j.ccr.2005.06.009, 16023599.
15. Sauthoff H, Heitner S, Rom WN, Hay JG. Deletion of the adenoviral E1b-19kD gene enhances tumor cell killing of a replicating adenoviral vector. Hum Gene Ther 2000, 11:379-388. 10.1089/10430340050015851, 10697113.
16. Sell S, Becker FF, Leffert HL, Watabe L. Expression of an oncodevelopmental gene product (alpha-fetoprotein) during fetal development and adult oncogenesis. Cancer Res 1976, 36:4239-4249.
17. Kanai F, Lan KH, Shiratori Y, Tanaka T, Ohashi M, Okudaira T, Yoshida Y, Wakimoto H, Hamada H, Nakabayashi H, et al. In vivo gene therapy for alpha-fetoprotein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase gene. Cancer Res 1997, 57:461-465.
18. Takahashi M, Sato T, Sagawa T, Lu Y, Sato Y, Iyama S, Yamada Y, Fukaura J, Takahashi S, Miyanishi K, et al. E1B-55K-deleted adenovirus expressing E1A-13S by AFP-enhancer/promoter is capable of highly specific replication in AFP-producing hepatocellular carcinoma and eradication of established tumor. Mol Ther 2002, 5:627-634. 10.1006/mthe.2002.0589, 11991754.
19. Wei RC, Cao X, Gui JH, Zhou XM, Zhong D, Yan QL, Huang WD, Qian QJ, Zhao FL, Liu XY. Augmenting the antitumor effect of TRAIL by SOCS3 with double-regulated replicating oncolytic adenovirus in hepatocellular carcinoma. Hum Gene Ther 22, 1109-1119.
20. Zhao X, Li J, He Y, Lan F, Fu L, Guo J, Zhao R, Ye Y, He M, Chong W, et al. A novel growth suppressor gene on chromosome 17p13.3 with a high frequency of mutation in human hepatocellular carcinoma. Cancer Res 2001, 61:7383-7387.
21. Wang G, Zhao Y, Liu X, Wang L, Wu C, Zhang W, Liu W, Zhang P, Cong W, Zhu Y, et al. Allelic loss and gain, but not genomic instability, as the major somatic mutation in primary hepatocellular carcinoma. Genes Chromosomes Cancer 2001, 31:221-227. 10.1002/gcc.1138, 11391792.
22. Gan Y, Gu J, Cai X, Hu J, Liu XY, Zhao X. Adenovirus-mediated HCCS1 overexpression elicits a potent antitumor efficacy on human colorectal cancer and hepatoma cells both in vitro and in vivo. Cancer Gene Ther 2008, 15:808-816. 10.1038/cgt.2008.52, 18617915.
23. Donello JE, Loeb JE, Hope TJ. Woodchuck hepatitis virus contains a tripartite posttranscriptional regulatory element. J Virol 1998, 72:5085-5092. 110072, 9573279.
24. Zufferey R, Donello JE, Trono D, Hope TJ. Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J Virol 1999, 73:2886-2892. 104046, 10074136.
25. Zhang Z, Huang Y, Newman K, Gu J, Zhang X, Wu H, Zhao M, Xianyu Z, Liu X. Reexpression of human somatostatin receptor gene 2 gene mediated by oncolytic adenovirus increases antitumor activity of tumor necrosis factor-related apoptosis-inducing ligand against pancreatic cancer. Clin Cancer Res 2009, 15:5154-5160. 10.1158/1078-0432.CCR-09-0025, 19671855.
26. Xiao T, Fan JK, Huang HL, Gu JF, Li LY, Liu XY. VEGI-armed oncolytic adenovirus inhibits tumor neovascularization and directly induces mitochondria-mediated cancer cell apoptosis. Cell Res 2010, 20:367-378. 10.1038/cr.2009.126, 19918267.
27. Yao F, Guo JM, Xu CF, Lou YL, Xiao BX, Zhou WH, Chen J, Hu YR, Liu Z, Hong GF. Detecting AFP mRNA in peripheral blood of the patients with hepatocellular carcinoma, liver cirrhosis and hepatitis. Clin Chim Acta 2005, 361:119-127. 10.1016/j.cccn.2005.05.005, 15993394.
28. Otsuru A, Nagataki S, Koji T, Tamaoki T. Analysis of alpha-fetoprotein gene expression in hepatocellular carcinoma and liver cirrhosis by in situ hybridization. Cancer 1988, 62:1105-1112. 10.1002/1097-0142(19880915)62:6<1105::AID-CNCR2820620613>3.0.CO;2-Z, 2457423.
29. Xu R, Zhang P, Huang J, Ge S, Lu J, Qian G. Sp1 and Sp3 regulate basal transcription of the survivin gene. Biochem Biophys Res Commun 2007, 356:286-292. 10.1016/j.bbrc.2007.02.140, 17350596.
30. Abou El Hassan MA, van der Meulen-Muileman I, Abbas S, Kruyt FA. Conditionally replicating adenoviruses kill tumor cells via a basic apoptotic machinery-independent mechanism that resembles necrosis-like programmed cell death. J Virol 2004, 78:12243-12251. 10.1128/JVI.78.22.12243-12251.2004, 525077, 15507611.