Advanced Glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1

Lipids in Health and Disease

Volumn 10, Issue , 2011, Pages

  Iborra, Rodrigo T ^a   MacHado Lima, Adriana ^a   Castilho, Gabriela ^a   Nunes, Valeria S ^a   Abdalla, Dulcinéia Sp ^a   Nakandakare, Edna R ^a   Passarelli, Marisa ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

7 ketocholesterol; ABCA 1; ABCG 1; advanced glycation; diabetes mellitus; oxysterols

Indexed keywords

7 OXOCHOLESTEROL; ABC TRANSPORTER A1; ABC TRANSPORTER G1; ADVANCED GLYCATION END PRODUCT; ALDEHYDE DERIVATIVE; GLYCOLALDEHYDE; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; OXYSTEROL; UNCLASSIFIED DRUG; 7-KETOCHOLESTEROL; ABC TRANSPORTER; ABCG1 PROTEIN, MOUSE; ACETALDEHYDE; CHOLESTEROL DERIVATIVE; DRUG DERIVATIVE; HYPOCHOLESTEROLEMIC AGENT; LIPOPROTEIN; LIVER X RECEPTOR; ORPHAN NUCLEAR RECEPTOR; OXIDIZED LOW DENSITY LIPOPROTEIN; OXIDIZING AGENT; STEROL;

ARTICLE; CONTROLLED STUDY; GAS CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LIPID STORAGE; MACROPHAGE; MASS SPECTROMETRY; PROTEIN EXPRESSION; ANIMAL; CELL LINE; DIABETIC ANGIOPATHY; DOWN REGULATION; DRUG EFFECT; DRUG POTENTIATION; IMMUNOLOGY; MASS FRAGMENTOGRAPHY; METABOLISM; MOUSE; OXIDATIVE STRESS;

ACETALDEHYDE; ANIMALS; ANTICHOLESTEREMIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE; DIABETIC ANGIOPATHIES; DOWN-REGULATION; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; KETOCHOLESTEROLS; LIPOPROTEINS; LIPOPROTEINS, HDL; LIPOPROTEINS, LDL; MACROPHAGES; MICE; ORPHAN NUCLEAR RECEPTORS; OXIDANTS; OXIDATIVE STRESS; STEROLS;

EID: 80055052806     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-10-172     Document Type: Article

References (23)

1. Do oxysterols control cholesterol homeostasis? Björkhem I, J Clin Invest 2002 110 6 725 30 12235099
2. Oxysterols: modulators of cholesterol metabolism and other processes. Schroepfer GJ Jr, Physiological Reviews 2000 80 1 361 554 10617772 (Pubitemid 30060568)
3. 7-Ketocholesterol-induced apoptosis. Involvement of several pro-apoptotic but also anti-apoptotic calcium-dependent transduction pathways. Berthier A, Lemaire-Ewing S, Prunet C, Montange T, Vejux A, Pais de Barros JP, Monier S, Gambert P, Lizard G, Néel D, Febs J 2005 272 12 3093 10.1111/j.1742-4658. 2005.04723.x 15955068 (Pubitemid 40904696)
4. Aminoguanidine and metformin prevent the reduced rate of HDL-mediated cell cholesterol efflux induced by formation of advanced glycation end products. Machado AP, Pinto RS, Moysés ZP, Nakandakare ER, Quintão EC, Passarelli, M Int J Biochem Cell Biol 2006 38 3 392 10.1016/j.biocel.2005.09.016 (Pubitemid 41821886)
5. Metformin restores impaired HDL-mediated cholesterol efflux due to glycation. Matsuki K, Tamasawa N, Yamashita M, Tanabe J, Murakami H, Matsui J, Imaizumi T, Satoh K, Suda T, Atherosclerosis 2009 206 2 434 10.1016/j. atherosclerosis.2009.03.003 19376519
6. AGE-BSA decreases ABCG1 expression and reduces macrophage cholesterol efflux to HDL. Isoda K, Folco EJ, Shimizu K, Libby P, Atherosclerosis 2007 192 2 298 10.1016/j.atherosclerosis.2006.07.023 17005185 (Pubitemid 46726331)
7. Plasma lipoproteins from patients with poorly controlled diabetes mellitus and "in vitro" glycation of lipoproteins enhance the transfer rate of cholesteryl ester from HDL to apo-B-containing lipoproteins. Passarelli M, Catanozi S, Nakandakare ER, Rocha JC, Morton RE, Shimabukuro AF, Quintão EC, Diabetologia 1997 40 9 1085 93 10.1007/s001250050791 9300246 (Pubitemid 27381972)
8. Decrease in reactive amino groups during oxidation or endothelial cell modification of LDL. Correlation with changes in receptor-mediated catabolism. Steinbrecher UP, Witztum JL, Parthasarathy S, Steinberg D, Arteriosclerosis 1987 7 2 135 10.1161/01.ATV.7.2.135 3107534
9. Protein measurement with the Folin phenol reagent. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ, J Biol Chem 1951 193 1 265 75 14907713
10. Cholesterol oxides as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus. Ferderbar S, Pereira EC, Apolinário E, Bertolami MC, Faludi A, Monte O, Calliari LE, Sales JE, Gagliardi AR, Xavier HT, Abdalla DS, Diabetes Metab Res Rev 2007 23 1 35 10.1002/dmrr.645 16634125 (Pubitemid 46152484)
11. Advanced glycation end products and cardiovascular disease. Peppa M, Raptis SA, Curr Diabetes Rev 2008 4 2 92 10.2174/157339908784220732 18473756
12. Macrophages, Oxysterols and Atherosclerosis. Shibata N, Glass CK, Circ J 2010 74 10 2045 51 10.1253/circj.CJ-10-0860 20838002
13. The roles of different pathways in the release of cholesterol from macrophages. Adorni MP, Zimetti F, Billheimer JT, Wang N, Rader DJ, Phillips MC, Rothblat GH, J Lipid Res 2007 48 11 2453 62 10.1194/jlr.M700274-JLR200 17761631 (Pubitemid 350058756)
14. Glycoxidation reduces cholesterol biosynthesis and increases cholesterol esterification in J-774 macrophages. Castilho G, Philipson PB, Pinto RS, Nakandakare ER, Quintão ECR, Passarelli M, Diabetes 2007 56 suppl 1 728 P 17327443
15. Apolipoprotein A-I-mediated efflux of sterols from oxidized LDL-loaded macrophage. Kritharides L, Jessup W, Mander EL, Dean RT, Arterioscler Thromb Vasc Biol 1995 15 276 10.1161/01.ATV.15.2.276 7749836
16. Sterol efflux is impaired from macrophage foam cells selectively enriched with 7-ketocholesterol. Gelissen IC, Brown AJ, Mander EL, Kritharides L, Dean RT, Jessup W, J Biol Chem 1996 271 30 17852 10.1074/jbc.271.30.17852 8663356 (Pubitemid 26250763)
17. Metabolism of oxidized LDL by macrophages. Jessup W, Kritharides L, Curr Opin Lipidol 2000 11 5 473 81 10.1097/00041433-200010000-00005 11048890
18. Esterification of oxysterols in human serum: effects on distribution and cellular uptake. Lin CY, Morel DW, J Lipid Res 1996 37 1 168 78 8820112 (Pubitemid 26052628)
19. AGE-albumin induces intracellular lipid accumulation by modifying the expression of genes involved in macrophage reverse cholesterol transport and cholesterol homeostasis. Machado-Lima A, Iborra RT, Pinto RS, Sartori CH, Oliveira ER, Stefano JT, Nakandakare ER, Giannella-Neto D, Corrêa- Giannella L, Passarelli M, Atherosclerosis 2011 12 suppl 1 35-36 P
20. Advanced glycation end product precursors impair ABCA1-dependent cholesterol removal from cells. Passarelli M, Tang C, McDonald TO, O'Brien KD, Gerrity RG, Heinecke JW, Oram JF, Diabetes 2005 54 7 2198 10.2337/diabetes.54.7. 2198 15983222 (Pubitemid 40911284)
21. The reduction in hdl receptor levels in macrophages is related to ros generation induced by advanced glycated albumin. Pinto RS, Paim BA, Vercesi AE, Castilho G, Nakandakare ER, Quintão EC, Passarelli M, Atherosclerosys 2011 12 suppl 1 35 P
22. Binding of receptor for advanced glycation end products (RAGE) ligants is not sufficient to induce inflammatory signals: lack of activity of endotoxin-free albumin-derived advanced glycation end products. Valencia JV, Mone M, Koehne C, Rediske J, Hughes TE, Diabetologia 2004 47 5 844 10.1007/s00125-004-1392-9 15127201 (Pubitemid 38756997)
23. Human atherosclerotic plaque lipid extract promotes expression of proinflammatory factors in human monocytes and macrophage-like cells. Yehuda H, Szuchman-Sapir A, Khatib S, Musa R, Tamir S, Atherosclerosis