The effect of glycemic variability on counterregulatory hormone responses to hypoglycemia in young children and adolescents with type 1 diabetes

Diabetes Technology and Therapeutics

Volumn 13, Issue 11, 2011, Pages 1085-1089

  Alghothani, Nora ^a   Dungan, Kathleen M ^b  

^a MOUNT CARMEL HEALTH SYSTEM   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; GLUCAGON; GLUCOSE; GROWTH HORMONE; HEMOGLOBIN A1C; HYDROCORTISONE; INSULIN; NORADRENALIN;

ADOLESCENT; ADRENALIN BLOOD LEVEL; ANALYTICAL PARAMETERS; ARTICLE; BLOOD GLUCOSE MONITORING; CHILD; CLINICAL ARTICLE; CONTINUOUS OVERALL NET GLYCEMIC ACTION; CONTROLLED STUDY; DISEASE DURATION; FEMALE; GLUCAGON BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLYCEMIC VARIABILITY; GROWTH HORMONE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HIGH BLOOD GLUCOSE INDEX; HORMONE DETERMINATION; HORMONE RESPONSE; HUMAN; HYDROCORTISONE BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN HYPOGLYCEMIA; LOW BLOOD GLUCOSE INDEX; MALE; NORADRENALIN BLOOD LEVEL; PRESCHOOL CHILD; PRIORITY JOURNAL; RISK ASSESSMENT; SCHOOL CHILD; SECONDARY ANALYSIS;

ADOLESCENT; BLOOD GLUCOSE; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FEMALE; GLUCAGON; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; MALE;

EID: 80055049507     PISSN: 15209156     EISSN: 15578593     Source Type: Journal    
DOI: 10.1089/dia.2011.0026     Document Type: Article

References (19)

1. Weber C, Schnell O: The assessment of glycemic variability and its impact on diabetes-related complications: an overview. Diabetes Technol Ther 2009;11:623-633.
2. Kovatchev BP, Cox DJ, Farhy LS, Straume M, Gonder-Frederick L, Clarke WL: Episodes of severe hypoglycemia in type 1 diabetes are preceded and followed within 48 hours by measurable disturbances in blood glucose. J Clin Endocrinol Metab 2000;85:4287-4292. (Pubitemid 32055388)
3. Cryer PE: Mechanisms of hypoglycemia-associated autonomic failure and its component syndromes in diabetes. Diabetes 2005;54:3592-3601. (Pubitemid 43334356)
4. Smith CB, Choudhary P, Pernet A, Hopkins D, Amiel SA: Hypoglycemia unawareness is associated with reduced adherence to therapeutic decisions in patients with type 1 diabetes: evidence from a clinical audit. Diabetes Care 2009;32: 1196-1198.
5. Diabetes Research in Children Network (DirecNet) Study Group. Public Dataset Downloads. public.direc.net/general/datasetDownload.php?stud=DirecNet Protocol #6 (accessed December 2009).
6. Diabetes Research in Children Network (DirecNet) Study Group: Blunted counterregulatory hormone responses to hypoglycemia in young children and adolescents with well-controlled type 1 diabetes. Diabetes Care 2009;32: 1954-1959.
7. Dagogo-Jack SE, Craft S, Cryer PE: Hypoglycemia-associated autonomic failure in insulin-dependent diabetes mellitus. J Clin Invest 1993;91:819-828.
8. McDonnell CM, Donath SM, Vidmar SI, Werther GA: A novel approach to continuous glucose analysis utilizing glycemic variation. Diabetes Technol Ther 2005;7:253-263. (Pubitemid 40586369)
9. Kovatchev BP, Otto E, Cox D: Evaluation of a new measure of blood glucose variability in diabetes. Diabetes Care 2006;29:2433-2438. (Pubitemid 44912248)
10. McCall AL, Kovatchev BP: The median is not the only message. A clinician's perspective on mathematical analysis of glycemic variability and modeling in diabetes mellitus. J Diabetes Sci Technol 2009;3:3-11.
11. Amiel SA, Sinonson DC, Tamborlane WV, DeFronzo RA, Sherwin RS: Rate of glucose fall does not affect counterregulatory hormone responses to hypoglycemia in normal and diabetic humans. Diabetes 1987;36:518-522. (Pubitemid 18023198)
12. Lilavivathana U, Brodows RG, Woolf PD, Campbell RG: Counterregulatory hormonal responses to rapid glucose lowering in diabetic man. Diabetes 1979;28:873-877. (Pubitemid 10250228)
13. DeFronzo RA, Andres R, Bedsoe TA, Boden G, Faloona GA, Tobin JD: A test of the hypothesis that the rate of fall in glucose concentration triggers counterregulatory hormonal responses in man. Diabetes 1977;26:445-452. (Pubitemid 8104800)
14. Quagliaro L, Piconi L, Assaloni R, Martinelli L, Motz E, Ceriello A: Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells: the role of protein kinase C and NAD(P)Hoxidase activation. Diabetes 2003;52:2795-2804. (Pubitemid 37339710)
15. Quagliaro L, Piconi L, Assaloni R, Da Ros R, Maier A, Zuodar G, Ceriello A: Intermittent high glucose enhances ICAM-1, VCAM-1 and E-selectin expression in human umbilical vein endothelial cells in culture: the distinct role of protein kinase C and mitochondrial superoxide production. Atherosclerosis 2005;183:259-267. (Pubitemid 41579276)
16. Diabetes Research in Children Network (DirecNet) Study Group: The accuracy of the Guardian RT continuous glucose monitor in children with type 1 diabetes. Diabetes Technol Ther 2008;10:266-272.
17. Galassetti P, Tate D, Neill RA, Morrey S, Wasserman DH, Davis SN: Effect of antecedent hypoglycemia on counterregulatory responses to subsequent euglycemic exercise in type 1 diabetes. Diabetes 2003;52:1761-1769. (Pubitemid 36792468)
18. Rizza RA, Cryer PE, Gerich JE: Role of glucagon, catecholamines, and growth hormone in human glucose counterregulation. J Clin Invest 1979;64:62-71.
19. Diabetes Research in Children Network (DirecNet) Study Group: Impaired overnight counterregulatory hormone responses to spontaneous hypoglycemia in children with type 1 diabetes. Pediatr Diabetes 2007;8:199-205.