Primary vascular tumors of bone: A spectrum of entities?

International Journal of Clinical and Experimental Pathology

Volumn 4, Issue 6, 2011, Pages 541-551

  Verbeke, Sofie L J ^a,b   Bovée, Judith V M G ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ANTWERP UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Angiosarcoma; Bone tumor; Epithelioid hemangioendothelioma; Epithelioid hemangioma; Hemangioma; Vascular tumor of bone

Indexed keywords

TUMOR MARKER;

ANGIOSARCOMA; BONE; BONE TUMOR; CLASSIFICATION; FEMALE; HEMANGIOENDOTHELIOMA; HUMAN; MALE; METABOLISM; REVIEW; VASCULARIZATION;

BONE AND BONES; BONE NEOPLASMS; FEMALE; HEMANGIOENDOTHELIOMA, EPITHELIOID; HEMANGIOSARCOMA; HUMANS; MALE; TUMOR MARKERS, BIOLOGICAL;

EID: 80055048349     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Review

References (72)

1. Wells HG. Relations of Multiple Vascular Tumors of Bone to Myeloma. Arch Surg 1921; 2: 435-442.
2. Dorfman HD, Steiner GC, and Jaffe HL. Vascular tumors of bone. Hum Pathol 1971; 2: 349-376.
3. Evans HL, Raymond AK, and Ayala AG. Vascular tumors of bone: A study of 17 cases other than ordinary hemangioma, with an evaluation of the relationship of hemangioendothelioma of bone to epithelioid hemangioma, epithelioid hemangioendothelioma, and high-grade angiosarcoma. Hum Pathol 2003; 34: 680-689.
4. O'Connell JX, Nielsen GP, and Rosenberg AE. Epithelioid vascular tumors of bone: a review and proposal of a classification scheme. Adv Anat Pathol 2001; 8: 74-82.
5. Unni KK, Ivins JC, Beabout JW, and Dahlin DC. Hemangioma, hemangiopericytoma, and hemangioendothelioma (angiosarcoma) of bone. Cancer 1971; 27: 1403-1414.
6. Wenger DE and Wold LE. Malignant vascular lesions of bone: radiologic and pathologic features. Skeletal Radiol 2000; 29: 619-631.
7. Bruder E, Perez-Atayde AR, Jundt G, Alomari AI, Rischewski J, Fishman SJ, Mulliken JB, and Kozakewich HP. Vascular lesions of bone in children, adolescents, and young adults. A clinicopathologic reappraisal and application of the ISSVA classification. Virchows Arch 2009; 454: 161-179.
8. Wenger DE and Wold LE. Benign vascular lesions of bone: radiologic and pathologic features. Skeletal Radiol 2000; 29: 63-74.
9. Damiani S, Corti B, Neri F, Collina G, and Bertoni F. Primary angiosarcoma of the parotid gland arising from benign congenital hemangioma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003; 96: 66-69.
10. Damiani S, Salfi NC, Collina G, and Neri F. Angiosarcoma of the parotid gland arising in congenital nonirradiated hemangioma. A case with adverse outcome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004; 97: 665-666.
11. Handfield-Jones SE, Kennedy CT, and Bradfield JB. Angiosarcoma arising in an angiomatous naevus following irradiation in childhood. Br J Dermatol 1988; 118: 109-112.
12. Mandahl N, Jin YS, Heim S, Willen H, Wennerberg J, Biorklund A, and Mitelman F. Trisomy 5 and loss of the Y chromosome as the sole cytogenetic anomalies in a cavernous hemangioma/ angiosarcoma. Genes Chromosomes Cancer 1990; 1: 315-316.
13. McRae RD, Gatland DJ, McNab Jones RF, and Khan S. Malignant transformation in a laryngeal hemangioma. Ann Otol Rhinol Laryngol 1990; 99: 562-565.
14. Obana Y, Tanji K, Furuta I, Yamazumi T, Hashimoto S, Kikuchi H, Tanaka S, and Ohba Y. A case of malignant transformation in thoracic vertebral hemangioma following repetitive irradiation and extraction. Pathol Int 1996; 46: 71-78.
15. Rossi S and Fletcher CD. Angiosarcoma arising in hemangioma/vascular malformation: report of four cases and review of the literature. Am J Surg Pathol 2002; 26: 1319-1329.
16. Yamamoto T, Iwasaki Y, Kurosaka M, and Minami R. Angiosarcoma arising from skeletal haemangiomatosis in an atomic bomb survivor. J Clin Pathol 2001; 54: 716-717.
17. Carter JH, Dickerson R, and Needy C. Angiosarcoma of bone: a review of the literature and presentation of a case. Ann Surg 1956; 144: 107-117.
18. Adler CP and Wold LE. Haemangioma and related lesions. 2002; 320-321.
19. Mulder JD, Schütte HE, Kroon HM, and Taconis WK. Benign vascular tumors: hemangioma. 1993; first edition: 507-516.
20. Fletcher CDM, Unni KK, and Mertens F. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. 2002.
21. Vermaat M, Vanel D, Kroon HM, Verbeke SLJ, Alberghini M, Bovée JVMG, and Bloem JL. Vascular tumors of bone: Imaging findings. Eur J Radiol 2010.
22. Kuzu I, Bicknell R, Harris AL, Jones M, Gatter KC, and Mason DY. Heterogeneity of vascular endothelial cells with relevance to diagnosis of vascular tumours. J Clin Pathol 1992; 45: 143-148.
23. Miettinen M, Lindenmayer AE, and Chaubal A. Endothelial cell markers CD31, CD34, and BNH9 antibody to H- and Y-antigens--evaluation of their specificity and sensitivity in the diagnosis of vascular tumors and comparison with von Willebrand factor. Mod Pathol 1994; 7: 82-90.
24. Pusztaszeri MP, Seelentag W, and Bosman FT. Immunohistochemical expression of endothelial markers CD31, CD34, von Willebrand factor, and Fli-1 in normal human tissues. J Histochem Cytochem 2006; 54: 385-395.
25. Verbeke SLJ, Bertoni F, Bacchini P, Sciot R, Fletcher CDM, Kroon HM, Hogendoorn PCW, and Bovée JVMG. Distinct Histologic Features Characterize Primary Angiosarcoma of Bone. Histopathology 2011;58:254-264.
26. Mankey CC, McHugh JB, Thomas DG, and Lucas DR. Can lymphangiosarcoma be resurrected? A clinicopathological and immunohistochemical study of lymphatic differentiation in 49 angiosarcomas. Histopathology 2010; 56: 364-371.
27. Miettinen M and Fetsch JF. Distribution of keratins in normal endothelial cells and a spectrum of vascular tumors: implications in tumor diagnosis. Hum Pathol 2000; 31: 1062-1067.
28. Ohsawa M, Naka N, Tomita Y, Kawamori D, Kanno H, and Aozasa K. Use of immunohistochemical procedures in diagnosing angiosarcoma. Evaluation of 98 cases. Cancer 1995; 75: 2867-2874.
29. Mirra JM, Picci P, and Gold RH. Vascular tumors. 1989; 20: 1335-1478.
30. Soler R, Pombo F, Bargiela A, Grana J, and Arnal F. Diffuse skeletal cystic angiomatosis: MR and CT findings. Eur J Radiol 1996; 22: 149-151.
31. Malik R, Malik R, Tandon S, and Tandon P. Skeletal angiomatosis - rare cause of bone destruction: a case report with review of literature. Indian J Pathol Microbiol 2008; 51: 515-518.
32. Levey DS, MacCormack LM, Sartoris DJ, Haghighi P, Resnick D, and Thorne R. Cystic angiomatosis: case report and review of the literature. Skeletal Radiol 1996; 25: 287-293.
33. Lateur L, Simoens CJ, Gryspeerdt S, Samson I, Mertens V, and Van DB. Skeletal cystic angiomatosis. Skeletal Radiol 1996; 25: 92-95.
34. Choi JJ and Murphey MD. Angiomatous skeletal lesions. Semin Musculoskelet Radiol 2000; 4: 103-112.
35. Dorfman HD and Czerniak B. Vascular lesions. 1998; 1st: 729-814.
36. Unni KK, Inwards CY, Bridge JA, Kindblom LG, and Wold LE. Vascular Tumors. 2005; 10: 261-279.
37. Shives TC, Beabout JW, and Unni KK. Massive osteolysis. Clin Orthop Relat Res 1993; 294: 267-276.
38. Murphey MD, Fairbairn KJ, Parman LM, Baxter KG, Parsa MB, and Smith WS. From the archives of the AFIP. Musculoskeletal angiomatous lesions: radiologic-pathologic correlation. Radiographics 1995; 15: 893-917.
39. Govani FS and Shovlin CL. Hereditary haemorrhagic telangiectasia: a clinical and scientific review. Eur J Hum Genet 2009; 17: 860-871.
40. Shehata BM, Stockwell CA, Castellano-Sanchez AA, Setzer S, Schmotzer CL, and Robinson H. Von Hippel-Lindau (VHL) disease: an update on the clinico-pathologic and genetic aspects. Adv Anat Pathol 2008; 15: 165-171.
41. von Knoch F, Grill F, Herneth AM, Kainberger F, Lang S, Ploier R, and von Knoch M. Skeletal cystic angiomatosis with severe hip joint deformation resembling massive osteolysis. Arch Orthop Trauma Surg 2001; 121: 485-488.
42. Nielsen GP, Srivastava A, Kattapuram S, Deshpande V, O'Connell JX, Mangham CD, and Rosenberg AE. Epithelioid hemangioma of bone revisited: a study of 50 cases. Am J Surg Pathol 2009; 33: 270-277.
43. Trindade F, Haro R, and Requena L. Giant angiolymphoid hyperplasia with eosinophilia on the chest. J Cutan Pathol 2009; 36: 493-496.
44. Busquets AC and Sanchez JL. Angiolymphoid hyperplasia with eosinophilia induced by trauma. Int J Dermatol 2006; 45: 1211-1214.
45. Tsuneyoshi M, Dorfman HD, and Bauer TW. Epithelioid hemangioendothelioma of bone. A clinicopathologic, ultrastructural, and immunohistochemical study. Am J Surg Pathol 1986; 10: 754-764.
46. Boudousquie AC, Lawce HJ, Sherman R, Olson S, Magenis RE, and Corless CL. Complex translocation [7; 22] identified in an epithelioid hemangioendothelioma. Cancer Genet Cytogenet 1996; 92: 116-121.
47. Mendlick MR, Nelson M, Pickering D, Johansson SL, Seemayer TA, Neff JR, Vergara G, Rosenthal H, and Bridge JA. Translocation t(1; 3) (p 36.3; q 25) is a nonrandom aberration in epithelioid hemangioendothelioma. Am J Surg Pathol 2001; 25: 684-687.
48. Kleer CG, Unni KK, and McLeod RA. Epithelioid hemangioendothelioma of bone. Am J Surg Pathol 1996; 20: 1301-1311.
49. Ramer MA, Lumerman H, Kopp W, Fisher KS, and Cohen SA. Epithelioid hemangioendothelioma of the maxilla: case report and review of literature. Periodontal Clin Investig 2001; 23: 31-35.
50. Dunlap JB, Magenis RE, Davis C, Himoe E, and Mansoor A. Cytogenetic analysis of a primary bone angiosarcoma. Cancer Genet Cytogenet 2009; 194: 1-3.
51. Hollstein M, Marion MJ, Lehman T, Welsh J, Harris CC, Martel-Planche G, Kusters I, and Montesano R. p53 mutations at A:T base pairs in angiosarcomas of vinyl chloride-exposed factory workers. Carcinogenesis 1994; 15: 1-3.
52. Soini Y, Welsh JA, Ishak KG, and Bennett WP. p53 mutations in primary hepatic angiosarcomas not associated with vinyl chloride exposure. Carcinogenesis 1995; 16: 2879-2881.
53. Weihrauch M, Markwarth A, Lehnert G, Wittekind C, Wrbitzky R, and Tannapfel A. Abnormalities of the ARF-p53 pathway in primary angiosarcomas of the liver. Hum Pathol 2002; 33: 884-892.
54. Domfeh AB, Fichera M, and Hunt JL. Allelic loss of 3 different tumor suppressor gene loci in benign and malignant endothelial tumors of the head and neck. Arch Pathol Lab Med 2006; 130: 1184-1187.
55. Naka N, Tomita Y, Nakanishi H, Araki N, Hongyo T, Ochi T, and Aozasa K. Mutations of p53 tumor-suppressor gene in angiosarcoma. Int J Cancer 1997; 71: 952-955.
56. Garcia JM, Gonzalez R, Silva JM, Dominguez G, Vegazo IS, Gamallo C, Provencio M, Espana P, and Bonilla F. Mutational status of K-ras and TP53 genes in primary sarcomas of the heart. Br J Cancer 2000; 82: 1183-1185.
57. Zu Y, Perle MA, Yan Z, Liu J, Kumar A, and Waisman J. Chromosomal abnormalities and p53 gene mutation in a cardiac angiosarcoma. Appl Immunohistochem Mol Morphol 2001; 9: 24-28.
58. Antonescu CR, Yoshida A, Guo T, Chang NE, Zhang L, Agaram NP, Qin LX, Brennan MF, Singer S, and Maki RG. KDR activating mutations in human angiosarcomas are sensitive to specific kinase inhibitors. Cancer Res 2009; 69: 7175-7179.
59. Manner J, Radlwimmer B, Hohenberger P, Mossinger K, Kuffer S, Sauer C, Belharazem D, Zettl A, Coindre JM, Hallermann C, Hartmann JT, Katenkamp D, Katenkamp K, Schoffski P, Sciot R, Wozniak A, Lichter P, Marx A, and Strobel P. MYC high level gene amplification is a distinctive feature of angiosarcomas after irradiation or chronic lymphedema. Am J Pathol 2010; 176: 34-39.
60. Przygodzki RM, Finkelstein SD, Keohavong P, Zhu D, Bakker A, Swalsky PA, Soini Y, Ishak KG, and Bennett WP. Sporadic and Thorotrastinduced angiosarcomas of the liver manifest frequent and multiple point mutations in K-ras -2. Lab Invest 1997; 76: 153-159.
61. O'Connell JX, Kattapuram SV, Mankin HJ, Bhan AK, and Rosenberg AE. Epithelioid hemangioma of bone. A tumor often mistaken for low-grade angiosarcoma or malignant hemangioendothelioma. Am J Surg Pathol 1993; 17: 610-617.
62. Campanacci M, Boriani S, and Giunti A. Hemangioendothelioma of bone: a study of 29 cases. Cancer 1980; 46: 804-814.
63. Stout AP and Murray MR. Hemangiopericytoma: a vascular tumor featuring Zimmermann's pericytes. Ann Surg 1942; 116: 26-33.
64. Fletcher CD. Haemangiopericytoma - A dying breed? Reappraisal of an 'entity' and its variants: a hypothesis. Current Diagnostic Pathology 1994; 1: 19-23.
65. Gengler C and Guillou L. Solitary fibrous tumour and haemangiopericytoma: evolution of a concept. Histopathology 2006; 48: 63-74.
66. Nappi O, Ritter JH, Pettinato G, and Wick MR. Hemangiopericytoma: histopathological pattern or clinicopathologic entity? Semin Diagn Pathol 1995; 12: 221-232.
67. Guillou L, Fletcher JA, Fletcher CD, and Mandahl N. Extrapleureal solitary fibrous tumour and haemangiopericytoma. 2002.
68. Mentzel T, Calonje E, Nascimento AG, and Fletcher CD. Infantile hemangiopericytoma versus infantile myofibromatosis. Study of a series suggesting a continuous spectrum of infantile myofibroblastic lesions. Am J Surg Pathol 1994; 18: 922-930.
69. Miettinen MM, el-Rifai W, Sarlomo-Rikala M, Andersson LC, and Knuutila S. Tumor sizerelated DNA copy number changes occur in solitary fibrous tumors but not in hemangiopericytomas. Mod Pathol 1997; 10: 1194-1200.
70. Bovée JVMG, Hogendoorn PCW, Wunder JS, and Alman BA. Cartilage tumours and bone development: molecular pathology and possible therapeutic targets. Nat Rev Cancer 2010; 10: 481-488.
71. Mentzel T, Palmedo G, and Kuhnen C. Welldifferentiated spindle cell liposarcoma ('atypical spindle cell lipomatous tumor') does not belong to the spectrum of atypical lipomatous tumor but has a close relationship to spindle cell lipoma: clinicopathologic, immunohistochemical, and molecular analysis of six cases. Mod Pathol 2010; 23: 729-736.
72. Walther A, Johnstone E, Swanton C, Midgley R, Tomlinson I, and Kerr D. Genetic prognostic and predictive markers in colorectal cancer. Nat Rev Cancer 2009; 9: 489-499.