Lymphotoxin-beta receptor blockade reduces CXCL13 in lacrimal glands and improves corneal integrity in the NOD model of Sjögren's syndrome

Arthritis Research and Therapy

Volumn 13, Issue 6, 2011, Pages

  Fava, Roy A ^a,b   Kennedy, Susan M ^a   Wood, Sheryl G ^a   Bolstad, Anne I ^c   Bienkowska, Jadwiga ^d   Papandile, Adrian ^d   Kelly, John A ^a,b   Mavragani, Clio P ^e   Gatumu, Margaret ^c   Skarstein, Kathrine ^c   Browning, Jeffrey L ^d  

^a VA MEDICAL CENTER   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF BERGEN   (Norway)

^d BIOGEN   (United States)

^e UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Chemokine; CXCL13; Keratoconjuntivitis sicca; Lymphotoxin beta; NOD mouse; Sjogren's syndrome

Indexed keywords

CXCL13 CHEMOKINE; FLUORESCEIN ISOTHIOCYANATE; LYMPHOTOXIN BETA RECEPTOR; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; MESSENGER RNA; MONOCLONAL ANTIBODY; MUCIN; SULFATED GLYCOPROTEIN P50;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; BIOACCUMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORNEA; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENE; GLYCAM1 GENE; HIGH ENDOTHELIAL VENULE; HOMOGENATE; HUMAN; IMMUNOHISTOCHEMISTRY; LACRIMAL GLAND; LIMIT OF QUANTITATION; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN RNA BINDING; REAL TIME POLYMERASE CHAIN REACTION; SECRETION (PROCESS); SJOEGREN SYNDROME; SLIT LAMP MICROSCOPY; STAINING; VENULE; AGED; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETICS; IMMUNOLOGY; KERATOCONJUNCTIVITIS SICCA; LACRIMAL APPARATUS; LACRIMAL FLUID; METABOLISM; MIDDLE AGED; NONOBESE DIABETIC MOUSE; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIUM;

ADULT; AGED; ANIMALS; ANTIBODIES, MONOCLONAL; CHEMOKINE CXCL13; CORNEA; ENDOTHELIUM, VASCULAR; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; KERATOCONJUNCTIVITIS SICCA; LACRIMAL APPARATUS; LYMPHOTOXIN BETA RECEPTOR; MALE; MICE; MICE, INBRED NOD; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; MUCINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SJOGREN'S SYNDROME; TEARS; VENULES;

EID: 80055039818     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3507     Document Type: Article

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