Effect of rickettsial toxin vapC on its eukaryotic host

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Audoly, Gilles ^a   Vincentelli, Renaud ^b   Edouard, Sophie ^a   Georgiades, Kalliopi ^a   Mediannikov, Oleg ^a   Gimenez, Grégory ^a   Socolovschi, Cristina ^a   Mège, Jean Louis ^a   Cambillau, Christian ^b   Raoult, Didier ^a  

^a CNRS   (France)

^b Centre National de la Recherche Scientifique   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; CHLORAMPHENICOL; DEXAMETHASONE; RIBONUCLEASE; UNCLASSIFIED DRUG; VAPC TOXIN;

ANTIBACTERIAL ACTIVITY; APOPTOSIS; ARTICLE; BACTERIAL GENE; BACTERIAL VIRULENCE; CELL STRAIN L 929; CONTROLLED STUDY; CYTOLYSIS; CYTOPLASM; ENDOTHELIUM CELL; ENZYME ACTIVITY; ESCHERICHIA COLI; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; GENE IDENTIFICATION; GENE STRUCTURE; GENE TRANSFER; GENOME ANALYSIS; HOST CELL; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; MAMMAL CELL; NICK END LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; OPERON; PLAQUE FORMING CELL; PROTEIN SECRETION; RICKETTSIA; RICKETTSIA BELLII; RICKETTSIA CONORII; RICKETTSIA FELIS; RICKETTSIA PROWAZEKII; SACCHAROMYCES CEREVISIAE; TOXIN ANTITOXIN ELEMENT; TRANSCRIPTION REGULATION; VAPB GENE; VAPC GENE; DRUG EFFECT; EUKARYOTE; PATHOGENICITY;

ARTHROPODA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; EUKARYOTA; MAMMALIA; RICKETTSIA; SACCHAROMYCES CEREVISIAE;

APOPTOSIS; BACTERIAL TOXINS; DEXAMETHASONE; EUKARYOTA; HOST-PATHOGEN INTERACTIONS; HUMANS; RICKETTSIA;

EID: 80055037194     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026528     Document Type: Article

References (37)

1. Raoult D, Roux V, (1997) Rickettsioses as paradigms of new or emerging infectious diseases. Clin Microbiol Rev 10: 694-719.
2. Merhej V, Raoult D, (2010) Rickettsial evolution in the light of comparative genomics. Biol Rev Camb Philos Soc BRV151 [pii];10.1111/j.1469-185X.2010.00151.x [doi].
3. Renvoise A, Merhej V, Georgiades K, Raoult D, (2011) Intracellular Rickettsiales: Insights into manipulators of eukaryotic cells. Trends Mol Med S1471-4914(11)00096-7 [pii];10.1016/j.molmed.2011.05.009 [doi].
4. Rovery C, Raoult D, (2008) Mediterranean spotted fever. Infect Dis Clin North Am 22: 515-30, ix S0891-5520(08)00022-6 [pii];10.1016/j.idc.2008.03.003 [doi].
5. Paddock CD, Greer PW, Ferebee TL, Singleton J Jr, McKechnie DB, et al. (1999) Hidden mortality attributable to Rocky Mountain spotted fever: immunohistochemical detection of fatal, serologically unconfirmed disease. J Infect Dis 179: 1469-1476 JID981267 [pii];10.1086/314776 [doi].
6. LaScola B, Meconi S, Fenollar F, Rolain JM, Roux V, et al. (2002) Emended description of Rickettsia felis (Bouyeret al. 2001), a temperature-dependent cultured bacterium. Int J Syst Evol Microbiol 52: 2035-2041.
7. Rolain JM, Franc M, Davoust B, Raoult D, (2003) Molecular detection of Bartonella quintana, B. koehlerae, B. henselae, B. clarridgeiae, Rickettsia felis, and Wolbachia pipientis in cat fleas, France. Emerg Infect Dis 9: 338-342.
8. Eremeeva ME, Madan A, Shaw CD, Tang K, Dasch GA, (2005) New perspectives on rickettsial evolution from new genome sequences of rickettsia, particularly R. canadensis, and Orientia tsutsugamushi. Ann N Y Acad Sci 1063: 47-63 1063/1/47 [pii];10.1196/annals.1355.006 [doi].
9. Ogata H, La SB, Audic S, Renesto P, Blanc G, et al. (2006) Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens. PLoS Genet 2: e76 10.1371/journal.pgen.0020076 [doi].
10. Ogata H, Renesto P, Audic S, Robert C, Blanc G, et al. (2005) The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite. PLoS Biol 3: e248 05-PLBI-RA-0181R2 [pii];10.1371/journal.pbio.0030248 [doi].
11. Pandey DP, Gerdes K, (2005) Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes. Nucleic Acids Res 33: 966-976 33/3/966 [pii];10.1093/nar/gki201 [doi].
12. Szekeres S, Dauti M, Wilde C, Mazel D, Rowe-Magnus DA, (2007) Chromosomal toxin-antitoxin loci can diminish large-scale genome reductions in the absence of selection. Mol Microbiol 63: 1588-1605 MMI5613 [pii];10.1111/j.1365-2958.2007.05613.x [doi].
13. Buts L, Lah J, Dao-Thi MH, Wyns L, Loris R, (2005) Toxin-antitoxin modules as bacterial metabolic stress managers. Trends Biochem Sci 30: 672-679 S0968-0004(05)00296-3 [pii];10.1016/j.tibs.2005.10.004 [doi].
14. Gerdes K, Christensen SK, Lobner-Olesen A, (2005) Prokaryotic toxin-antitoxin stress response loci. Nat Rev Microbiol 3: 371-382 nrmicro1147 [pii];10.1038/nrmicro1147 [doi].
15. Goulard C, Langrand S, Carniel E, Chauvaux S, (2010) The Yersinia pestis chromosome encodes active addiction toxins. J Bacteriol 192: 3669-3677 JB.00336-10 [pii];10.1128/JB.00336-10 [doi].
16. Georgiades K, Raoult D, (2011) Genomes of the most dangerous epidemic bacteria have a virulence repertoire characterized by fewer genes but more toxin-antitoxin modules. PLoS One 6: e17962 10.1371/journal.pone.0017962 [doi].
17. Sat B, Hazan R, Fisher T, Khaner H, Glaser G, et al. (2001) Programmed cell death in Escherichia coli: some antibiotics can trigger mazEF lethality. J Bacteriol 183: 2041-2045 10.1128/JB.183.6.2041-2045.2001 [doi].
18. Nieto C, Sadowy E, de la Campa AG, Hryniewicz W, Espinosa M, (2010) The relBE2Spn toxin-antitoxin system of Streptococcus pneumoniae: role in antibiotic tolerance and functional conservation in clinical isolates. PLoS One 5: e11289 10.1371/journal.pone.0011289 [doi].
19. Hood RD, Singh P, Hsu F, Guvener T, Carl MA, et al. (2010) A type VI secretion system of Pseudomonas aeruginosa targets a toxin to bacteria. Cell Host Microbe 7: 25-37 S1931-3128(09)00417-X [pii];10.1016/j.chom.2009.12.007 [doi].
20. Kristoffersen P, Jensen GB, Gerdes K, Piskur J, (2000) Bacterial toxin-antitoxin gene system as containment control in yeast cells. Appl Environ Microbiol 66: 5524-5526.
21. Picardeau M, Le DC, Richard GF, Saint GI, (2003) The spirochetal chpK-chromosomal toxin-antitoxin locus induces growth inhibition of yeast and mycobacteria. FEMS Microbiol Lett 229: 277-281 S0378109703008486 [pii].
22. Yamamoto TA, Gerdes K, Tunnacliffe A, (2002) Bacterial toxin RelE induces apoptosis in human cells. FEBS Lett 519: 191-194 S0014579302027643 [pii].
23. Workman JB, Hightower JA, Borges FJ, Furman JE, Parker RT, (1952) Cortisone as an Adjunct to Chloramphenicol in the Treatment of Rocky Mountain Spotted Fever. New England Journal of Medicine 246: 962-966 doi:10.1056/NEJM195206192462503.
24. Woodward TE, (1978) Rocky Mountain spotted fever. Med Times 106: 90.
25. Ogata H, Audic S, Renesto-Audiffren P, Fournier PE, Barbe V, et al. (2001) Mechanisms of evolution in Rickettsia conorii and R. prowazekii. Science 293: 2093-2098 10.1126/science.1061471 [doi];293/5537/2093 [pii].
26. Merhej V, El Karkouri K, Raoult D, (2009) Whole genome-based phylogenetic analysis of Rickettsiae. Clin Microbiol Infect 15 (Suppl 2): 336-337 CLM2265 [pii];10.1111/j.1469-0691.2008.02265.x [doi].
27. Raoult D, Yeaman MR, Baca OG, (1989) Susceptibility of Coxiella burnetii to pefloxacin and ofloxacin in ovo and in persistently infected L929 cells. Antimicrob Agents Chemother 33: 621-623.
28. Saisongkorh W, Robert C, La SB, Raoult D, Rolain JM, (2010) Evidence of transfer by conjugation of type IV secretion system genes between Bartonella species and Rhizobium radiobacter in amoeba. PLoS One 5: e12666 10.1371/journal.pone.0012666 [doi].
29. Merhej V, Royer-Carenzi M, Pontarotti P, Raoult D, (2009) Massive comparative genomic analysis reveals convergent evolution of specialized bacteria. Biol Direct 4: 13 1745-6150-4-13 [pii];10.1186/1745-6150-4-13 [doi].
30. Hoffman SL, Punjabi NH, Kumala S, Moechtar MA, Pulungsih SP, et al. (1984) Reduction of mortality in chloramphenicol-treated severe typhoid fever by high-dose dexamethasone. N Engl J Med 310: 82-88 10.1056/NEJM198401123100203 [doi].
31. Botelho-Nevers E, Rolain JM, Espinosa L, Raoult D, (2008) Statins limit Rickettsia conorii infection in cells. Int J Antimicrob Agents 32: 344-348 S0924-8579(08)00227-6 [pii];10.1016/j.ijantimicag.2008.04.027 [doi].
32. Edgar R, Domrachev M, Lash AE, (2002) Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 30: 207-210.
33. Vincentelli R, Bignon C, Gruez A, Canaan S, Sulzenbacher G, et al. (2003) Medium-scale structural genomics: strategies for protein expression and crystallization. Acc Chem Res 36: 165-172 10.1021/ar010130s [doi].
34. Mattison K, Wilbur JS, So M, Brennan RG, (2006) Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs. J Biol Chem 281: 37942-37951 M605198200 [pii];10.1074/jbc.M605198200 [doi].
35. Renesto P, Samson L, Ogata H, Azza S, Fourquet P, et al. (2006) Identification of two putative rickettsial adhesins by proteomic analysis. Res Microbiol 157: 605-612 S0923-2508(06)00057-X [pii];10.1016/j.resmic.2006.02.002 [doi].
36. Pudney M, Varma MG, Leake CJ, (1973) Establishment of a cell line (XTC-2) from the South African clawed toad, Xenopus laevis. Experientia 29: 466-467.
37. Zarda B, Amann R, Wallner G, Schleifer KH, (1991) Identification of single bacterial cells using digoxigenin-labelled, rRNA-targeted oligonucleotides. J Gen Microbiol 137: 2823-2830.