Prostatic intraepithelial neoplasia: Its morphological and molecular diagnosis and clinical significance

BJU International

Volumn 108, Issue 9, 2011, Pages 1394-1401

  Montironi, Rodolfo ^a   Mazzucchelli, Roberta ^a   Lopez Beltran, Antonio ^b   Scarpelli, Marina ^a   Cheng, Liang ^c  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b Universidad de Cordoba   (Spain)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

adenosis; atypical adenomatous hyperplasia; high grade PIN; proliferative inflammatory atrophy; prostate cancer; prostatic intraepithelial neoplasia

Indexed keywords

CYTOKERATIN; MYC PROTEIN; PROTEIN BCL 2; PROTEIN P16; PROTEIN P27; PROTEIN P53;

ACINAR CELL CARCINOMA; BASAL CELL HYPERPLASIA; BENIGN TUMOR; CANCER INCIDENCE; CELL DIFFERENTIATION; CELL PROLIFERATION; CLEAR CELL CRIBRIFORM HYPERPLASIA; DIFFERENTIAL DIAGNOSIS; HIGH GRADE PROSTATIC INTRAEPITHELIAL NEOPLASIA; HUMAN; INTRADUCTAL CARCINOMA; MALIGNANT NEOPLASTIC DISEASE; MOLECULAR DIAGNOSIS; NEEDLE BIOPSY; PREDICTION; PRIORITY JOURNAL; PROSTATE BIOPSY; PROSTATE CANCER; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROTEIN EXPRESSION; REVIEW; RISK FACTOR; SECRETORY CELL; SIGNET RING CARCINOMA;

EID: 80055024575     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2011.010413.x     Document Type: Review

References (20)

1. McNeal JE, Bostwick DG,. Intraductal dysplasia: a premalignant lesion of the prostate. Hum Pathol 1986; 17: 64-71 (Pubitemid 16163546)
2. Ayala AG, Ro JY,. Prostatic intraepithelial neoplasia: recent advances. Arch Pathol Lab Med 2007; 131: 1257-6
3. Epstein JI,. Precursor lesions to prostatic adenocarcinoma. Virchows Arch 2009; 454: 1-16
4. Montironi R, Mazzucchelli R, Lopez-Beltran A, Cheng L, Scarpelli M,. Mechanisms of disease: high-grade prostatic intraepithelial neoplasia and other proposed preneoplastic lesions in the prostate. Nat Clin Pract Urol 2007; 4: 321-32 (Pubitemid 46901993)
5. Montironi R, Mazzucchelli R, Scarpelli M,. Precancerous lesions and conditions of the prostate: from morphological and biological characterization to chemoprevention. Ann N Y Acad Sci 2002; 963: 169-8
6. Kumaresan K, Kakkar N, Verma A, Mandal AK, Singh SK, Joshi K,. Diagnostic utility of alpha-methylacyl CoA racemase (P504S) & HMWCK in morphologically difficult prostate cancer. Diagn Pathol 2010; 5: 83
7. Wang X, Hickey RJ, Malkas LH, et al,. Elevated expression of cancer-associated proliferating cell nuclear antigen in high-grade prostatic intraepithelial neoplasia and prostate cancer. Prostate 2010; [Epub ahead of print]
8. Bostwick DG, Ma J,. Over-diagnosis of high-grade prostatic intraepithelial neoplasia: a prospective study of 251 cases. BJU Int 2007; 100: 1036-9 (Pubitemid 47537667)
9. Cohen RJ, Shannon BA, Weinstein SL,. Intraductal carcinoma of the prostate gland with transmucosal spread to the seminal vesicle: a lesion distinct from high-grade prostatic intraepithelial neoplasia. Arch Pathol Lab Med 2007; 131: 1122-5 (Pubitemid 47057904)
10. Tavora F, Epstein JI,. High-grade prostatic intraepithelial neoplasia like ductal adenocarcinoma of the prostate: a clinicopathologic study of 28 cases. Am J Surg Pathol 2008; 32: 1060-7
11. Mosquera JM, Perner S, Genega EM, et al,. Characterization of TMPRSS2-ERG fusion high-grade prostatic intraepithelial neoplasia and potential clinical implications. Clin Cancer Res 2008; 14: 3380-5
12. Eskicorapci SY, Guliyev F, Islamoglu E, Ergen A, Ozen H,. The effect of prior biopsy scheme on prostate cancer detection for repeat biopsy population: results of the 14-core prostate biopsy technique. Int Urol Nephrol 2007; 39: 189-95 (Pubitemid 46722965)
13. Srigley JR, Merrimen JL, Jones G, Jamal M,. Multifocal high-grade prostatic intraepithelial neoplasia is still a significant risk factor for adenocarcinoma. Can Urol Assoc J 2010; 4: 434
14. Epstein JI, Herawi M,. Prostate needle biopsies containing prostatic intraepithelial neoplasia or atypical foci suspicious for carcinoma: implications for patient care. J Urol 2006; 175: 820-34 (Pubitemid 43199991)
15. Laurila M, van der Kwast T, Bubendorf L, et al,. Detection rates of cancer, high grade PIN and atypical lesions suspicious for cancer in the European Randomized Study of Screening for Prostate Cancer. Eur J Cancer 2010; 46: 3068-72
16. Schlesinger C, Bostwick DG, Iczkowski KA,. High-grade prostatic intraepithelial neoplasia and atypical small acinar proliferation: predictive value for cancer in current practice. Am J Surg Pathol 2005; 29: 1201-7 (Pubitemid 41232993)
17. Morote J, Fernández S, Alaña L, et al,. PTOV1 expression predicts prostate cancer in men with isolated high-grade prostatic intraepithelial neoplasia in needle biopsy. Clin Cancer Res 2008; 14: 2617-22
18. Hull D, Ma J, Singh H, Hossain D, Qian J, Bostwick DG,. Precursor of prostate-specific antigen expression in prostatic intraepithelial neoplasia and adenocarcinoma: a study of 90 cases. BJU Int 2009; 104: 915-8
19. Lefkowitz GK, Taneja SS, Brown J, Melamed J, Lepor H,. Followup interval prostate biopsy 3 years after diagnosis of high grade prostatic intraepithelial neoplasia is associated with high likelihood of prostate cancer, independent of change in prostate specific antigen levels. J Urol 2002; 168: 1415-8 (Pubitemid 35034136)
20. Izawa JI, Lega I, Downey D, Chin JL, Luke PP,. Do all patients with high-grade prostatic intraepithelial neoplasia on initial prostatic biopsy eventually progress to clinical prostate cancer? BJU Int 2005; 96: 320-3 (Pubitemid 41097674)