High IGFBP2 expression correlates with tumor severity in pediatric rhabdomyosarcoma

American Journal of Pathology

Volumn 179, Issue 5, 2011, Pages 2611-2624

  Tombolan, Lucia ^a   Orso, Francesca ^b   Guzzardo, Vincenza ^a   Casara, Silvia ^a   Zin, Angelica ^a   Bonora, Massimo ^c   Romualdi, Chiara ^a   Giorgi, Carlotta ^c   Bisogno, Gianni ^a   Alaggio, Rita ^a   Pinton, Paolo ^c   De Pitt, Cristiano ^a   Taverna, Daniela ^b   Rosolen, Angelo ^a   Lanfranchi, Gerolamo ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c UNIVERSITY OF FERRARA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; AEQUORIN; SOMATOMEDIN BINDING PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CANCER INVASION; CARCINOGENESIS; CELL CYCLE; CONTROLLED STUDY; CYTOSKELETON; DISEASE SEVERITY; FEMALE; GOLGI COMPLEX; HUMAN; HUMAN CELL; IN VIVO STUDY; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RHABDOMYOSARCOMA;

ANIMALS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL MOVEMENT; CHILD; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; GENE SILENCING; GOLGI APPARATUS; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 2; MICE; NEOPLASM INVASIVENESS; NEOPLASM SEEDING; PAIRED BOX TRANSCRIPTION FACTORS; RHABDOMYOSARCOMA; RNA, SMALL INTERFERING; TUMOR MARKERS, BIOLOGICAL;

EID: 80054998863     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.07.018     Document Type: Article

References (57)

1. S.B. Wheatcroft, and M.T. Kearney IGF-dependent and IGF-independent actions of IGF-binding protein-1 and -2: implications for metabolic homeostasis Trends Endocrinol Metab 20 2009 153 162
2. S.M. Firth, and R.C. Baxter Cellular actions of the insulin-like growth factor binding proteins Endocr Rev 23 2002 824 854
3. K.W. Frommer, K. Reichenmiller, B.S. Schutt, A. Hoeflich, M.B. Ranke, G. Dodt, and M.W. Elmlinger IGF-independent effects of IGFBP-2 on the human breast cancer cell line Hs578T J Mol Endocrinol 37 2006 13 23
4. B.S. Schutt, M. Langkamp, U. Rauschnabel, M.B. Ranke, and M.W. Elmlinger Integrin-mediated action of insulin-like growth factor binding protein-2 in tumor cells J Mol Endocrinol 32 2004 859 868
5. V.C. Russo, B.S. Schutt, E. Andaloro, S.I. Ymer, A. Hoeflich, M.B. Ranke, L.A. Bach, and G.A. Werther Insulin-like growth factor binding protein-2 binding to extracellular matrix plays a critical role in neuroblastoma cell proliferation, migration, and invasion Endocrinology 146 2005 4445 4455
6. J.J. Pereira, T. Meyer, S.E. Docherty, H.H. Reid, J. Marshall, E.W. Thompson, J. Rossjohn, and J.T. Price Bimolecular interaction of insulin-like growth factor (IGF) binding protein-2 with alphavbeta3 negatively modulates IGF-I-mediated migration and tumor growth Cancer Res 64 2004 977 984
7. G.N. Fuller, C.H. Rhee, K.R. Hess, L.S. Caskey, R. Wang, J.M. Bruner, W.K. Yung, and W. Zhang Reactivation of insulin-like growth factor binding protein 2 expression in glioblastoma multiforme: a revelation by parallel gene expression profiling Cancer Res 59 1999 4228 4232
8. H. Wang, W. Shen, H. Huang, L. Hu, L. Ramdas, Y.H. Zhou, W.S. Liao, G.N. Fuller, and W. Zhang Insulin-like growth factor binding protein 2 enhances glioblastoma invasion by activating invasion-enhancing genes Cancer Res 63 2003 4315 4321
9. G.K. Wang, L. Hu, G.N. Fuller, and W. Zhang An interaction between insulin-like growth factor-binding protein 2 (IGFBP2) and integrin alpha5 is essential for IGFBP2-induced cell mobility J Biol Chem 281 2006 14085 14091
10. T. Fukushima, T. Tezuka, T. Shimomura, S. Nakano, and H. Kataoka Silencing of insulin-like growth factor-binding protein-2 in human glioblastoma cells reduces both invasiveness and expression of progression-associated gene CD24 J Biol Chem 282 2007 18634 18644
11. S.W. Song, G.N. Fuller, A. Khan, S. Kong, W. Shen, E. Taylor, L. Ramdas, F.F. Lang, and W. Zhang IIp45, an insulin-like growth factor binding protein 2 (IGFBP-2) binding protein, antagonizes IGFBP-2 stimulation of glioma cell invasion Proc Natl Acad Sci U S A 100 2003 13970 13975
12. L.M. Moore, K.M. Holmes, S.M. Smith, Y. Wu, E. Tchougounova, L. Uhrbom, R. Sawaya, J.M. Bruner, G.N. Fuller, and W. Zhang IGFBP2 is a candidate biomarker for Ink4a-Arf status and a therapeutic target for high-grade gliomas Proc Natl Acad Sci U S A 106 2009 16675 16679
13. C.M. Perks, E.G. Vernon, A.H. Rosendahl, D. Tonge, and J.M. Holly IGF-II and IGFBP-2 differentially regulate PTEN in human breast cancer cells Oncogene 26 2007 5966 5972
14. R. Mehrian-Shai, C.D. Chen, T. Shi, S. Horvath, S.F. Nelson, J.K. Reichardt, and C.L. Sawyers Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K/Akt pathway activation in glioblastoma and prostate cancer Proc Natl Acad Sci U S A 104 2007 5563 5568
15. S.M. Dunlap, J. Celestino, H. Wang, R. Jiang, E.C. Holland, G.N. Fuller, and W. Zhang Insulin-like growth factor binding protein 2 promotes glioma development and progression Proc Natl Acad Sci U S A 104 2007 11736 11741
16. D.J. Degraff, A.A. Aguiar, and R.A. Sikes Disease evidence for IGFBP-2 as a key player in prostate cancer progression and development of osteosclerotic lesions Am J Transl Res 1 2009 115 130
17. E.J. Lee, C. Mircean, I. Shmulevich, H. Wang, J. Liu, A. Niemistö, J.J. Kavanagh, J.H. Lee, and W. Zhang Insulin-like growth factor binding protein 2 promotes ovarian cancer cell invasion Mol Cancer 4 2005 7
18. J.L. Martin, and R.C. Baxter Expression of insulin-like growth factor binding protein-2 by MCF-7 breast cancer cells is regulated through the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway Endocrinology 148 2007 2532 2541
19. J.L. Eiseman, J. Guo, R.K. Ramanathan, C.P. Belani, D.B. Solit, H.I. Scher, S.P. Ivy, E.G. Zuhowski, and M.J. Egorin Evaluation of plasma insulin-like growth factor binding protein 2 and Her-2 extracellular domain as biomarkers for 17-allylamino-17-demethoxygeldanamycin treatment of adult patients with advanced solid tumors Clin Cancer Res 13 2007 2121 2127
20. A.I. So, R.J. Levitt, B. Eigl, L. Fazli, M. Muramaki, S. Leung, M.C. Cheang, T.O. Nielsen, M. Gleave, and M. Pollak Insulin-like growth factor binding protein-2 is a novel therapeutic target associated with breast cancer Clin Cancer Res 14 2008 6944 6954
21. S.V. Allander, P.B. Illei, Y. Chen, C.R. Antonescu, M. Bittner, M. Ladanyi, and P.S. Meltzer Expression profiling of synovial sarcoma by cDNA microarrays: association of ERBB2, IGFBP2, and ELF3 with epithelial differentiation Am J Pathol 161 2002 1587 1595
22. K. Tschoep, A. Kohlmann, M. Schlemmer, T. Haferlach, and R.D. Issels Gene expression profiling in sarcomas Crit Rev Oncol Hematol 63 2007 111 124
23. R. Dagher, and L. Helman Rhabdomyosarcoma: an overview Oncologist 4 1999 34 44
24. F.G. Barr Molecular genetics and pathogenesis of rhabdomyosarcoma J Pediatr Hematol Oncol 19 1997 483 491
25. J. Anderson, A. Ramsay, S. Gould, and K. Pritchard-Jones PAX3-FKHR induces morphological change and enhances cellular proliferation and invasion in rhabdomyosarcoma Am J Pathol 159 2001 1089 1096
26. P.H. Sorensen, J.C. Lynch, S.J. Qualman, R. Tirabosco, J.F. Lim, H.M. Maurer, J.A. Bridge, W.M. Crist, T.J. Triche, and F.G. Barr PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group J Clin Oncol 20 2002 2672 2679
27. C. Keller, and M.R. Capecchi New genetic tactics to model alveolar rhabdomyosarcoma in the mouse Cancer Res 65 2005 7530 7532
28. E. Davicioni, F.G. Finckenstein, V. Shahbazian, J.D. Buckley, T.J. Triche, and M.J. Anderson Identification of a PAX-FKHR gene expression signature that defines molecular classes and determines the prognosis of alveolar rhabdomyosarcomas Cancer Res 66 2006 6936 6946
29. C. De Pitta, L. Tombolan, G. Albiero, F. Sartori, C. Romualdi, G. Jurman, M. Carli, C. Furlanello, G. Lanfranchi, and A. Rosolen Gene expression profiling identifies potential relevant genes in alveolar rhabdomyosarcoma pathogenesis and discriminates PAX3-FKHR positive and negative tumors Int J Cancer 118 2006 2772 2781
30. E. Charytonowicz, C. Cordon-Cardo, I. Matushansky, and M. Ziman Alveolar rhabdomyosarcoma: is the cell of origin a mesenchymal stem cell? Cancer Lett 279 2009 126 136
31. M.W. Pfaffl A new mathematical model for relative quantification in real-time RT-PCR Nucleic Acids Res 29 2001 e45
32. -ΔΔCT Method Methods 25 2001 402 408
33. A.I. Saeed, V. Sharov, J. White, J. Li, W. Liang, N. Bhagabati, J. Braisted, M. Klapa, T. Currier, M. Thiagarajan, A. Sturn, M. Snuffin, A. Rezantsev, D. Popov, A. Ryltsov, E. Kostukovich, I. Borisovsky, Z. Liu, A. Vinsavich, V. Trush, and J. Quackenbush TM4: a free, open-source system for microarray data management and analysis Biotechniques 34 2003 374 378
34. V.G. Tusher, R. Tibshirani, and G. Chu Significance analysis of microarrays applied to the ionizing radiation response Proc Natl Acad Sci U S A 98 2001 5116 5121
35. A.I. Saeed, N.K. Bhagabati, J.C. Braisted, W. Liang, V. Sharov, E.A. Howe, J. Li, M. Thiagarajan, J.A. White, and J. Quackenbush TM4 microarray software suite Methods Enzymol 411 2006 134 193
36. W. Huang da, B.T. Sherman, R. Stephens, M.W. Baseler, H.C. Lane, and R.A. Lempicki DAVID gene ID conversion tool Bioinformation 2 2008 428 430
37. R. Edgar, M. Domrachev, and A.E. Lash Gene Expression Omnibus: NCBI gene expression and hybridization array data repository Nucleic Acids Res 30 2002 207 210
38. P. Pinton, T. Pozzan, and R. Rizzuto The Golgi apparatus is an inositol 1,4,5-trisphosphate-sensitive Ca2+ store, with functional properties distinct from those of the endoplasmic reticulum EMBO J 17 1998 5298 5308
39. P. Pinton, A. Rimessi, A. Romagnoli, A. Prandini, and R. Rizzuto Biosensors for the detection of calcium and pH Methods Cell Biol 80 2007 297 325
40. M.V. Schiaffino, and C. Tacchetti The ocular albinism type 1 (OA1) protein and the evidence for an intracellular signal transduction system involved in melanosome biogenesis Pigment Cell Res 18 2005 227 233
41. T. Dull, R. Zufferey, M. Kelly, R.J. Mandel, M. Nguyen, D. Trono, and L. Naldini A third-generation lentivirus vector with a conditional packaging system J Virol 72 1998 8463 8471
42. Y. Misumi, K. Miki, A. Takatsuki, G. Tamura, and Y. Ikehara Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes J Biol Chem 261 1986 11398 11403
43. J.F. Presley, N.B. Cole, T.A. Schroer, K. Hirschberg, K.J. Zaal, and J. Lippincott-Schwartz ER-to-Golgi transport visualized in living cells Nature 389 1997 81 85
44. E. Kuismanen, and J. Saraste Low temperature-induced transport blocks as tools to manipulate membrane traffic Methods Cell Biol 32 1989 257 274
45. C. Romualdi, C. De Pitt, L. Tombolan, S. Bortoluzzi, F. Sartori, A. Rosolen, and G. Lanfranchi Defining the gene expression signature of rhabdomyosarcoma by meta-analysis BMC Genomics 7 2006 287
46. T. Babiá, I. Ayala, F. Valderrama, E. Mato, M. Bosch, J.F. Santarén, J. Renau-Piqueras, J.W. Kok, T.M. Thomson, and G. Egea N-Ras induces alterations in Golgi complex architecture and in constitutive protein transport J Cell Sci 112 Pt 4 1999 477 489
47. S.L. Forsburg Eukaryotic MCM proteins: beyond replication initiation Microbiol Mol Biol Rev 68 2004 109 131
48. K.E. Tachibana, M.A. Gonzalez, and N. Coleman Cell-cycle-dependent regulation of DNA replication and its relevance to cancer pathology J Pathol 205 2005 123 129
49. J.K. Kim, and J.A. Diehl Nuclear cyclin D1: an oncogenic driver in human cancer J Cell Physiol 220 2009 292 296
50. Z. Li, C. Wang, G.C. Prendergast, and R.G. Pestell Cyclin D1 functions in cell migration Cell Cycle 5 2006 2440 2442
51. M. Oser, and J. Condeelis The cofilin activity cycle in lamellipodia and invadopodia J Cell Biochem 108 2009 1252 1262
52. C.B. Guo, S. Wang, C. Deng, D.L. Zhang, F.L. Wang, and X.Q. Jin Relationship between matrix metalloproteinase 2 and lung cancer progression Mol Diagn Ther 11 2007 183 192
53. S. Makawita, M. Ho, A.D. Durbin, P.S. Thorner, D. Malkin, and G.R. Somers Expression of insulin-like growth factor pathway proteins in rhabdomyosarcoma: IGF-2 expression is associated with translocation-negative tumors Pediatr Dev Pathol 12 2009 127 135
54. G. Brady, E. O'Regan, I. Miller, A. Ogungbowale, S. Kapas, and S.J. Crean Serum levels of insulin-like growth factors (IGFs) and their binding proteins (IGFBPs), -1, -2, -3, in oral cancer Int J Oral Maxillofac Surg 36 2007 259 262
55. S.F. Shariat, D.J. Lamb, M.W. Kattan, C. Nguyen, J. Kim, J. Beck, T.M. Wheeler, and K.M. Slawin Association of preoperative plasma levels of insulin-like growth factor I and insulin-like growth factor binding proteins-2 and -3 with prostate cancer invasion, progression, and metastasis J Clin Oncol 20 2002 833 841
56. Y. Lin, T. Jiang, K. Zhou, L. Xu, B. Chen, G. Li, X. Qiu, T. Jiang, W. Zhang, and S.W. Song Plasma IGFBP-2 levels predict clinical outcomes of patients with high-grade gliomas Neuro Oncol 11 2009 468 476
57. P. Vorwerk, K. Mohnike, H. Wex, F.W. Rohl, M. Zimmermann, W.F. Blum, and U. Mittler Insulin-like growth factor binding protein-2 at diagnosis of childhood acute lymphoblastic leukemia and the prediction of relapse risk J Clin Endocrinol Metab 90 2005 3022 3027