Development of a negligible depletion-solid phase microextraction method to determine the free concentration of chlorpromazine in aqueous samples containing albumin

Journal of Chromatography A

Volumn 1218, Issue 47, 2011, Pages 8529-8535

  Broeders, Jessica J W ^a   Blaauboer, Bas J ^a   Hermens, Joop L M ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Albumin; Chlorpromazine; Free concentration; Nd SPME

Indexed keywords

ALBUMIN; AQUEOUS SAMPLES; BOVINE SERUM ALBUMINS; CHLORPROMAZINE; COATING THICKNESS; EXPOSURE-TIME; FREE CONCENTRATION; HPLC METHOD; IN-LINE; IN-VITRO; IN-VIVO; MICROEXTRACTION; ND-SPME; POLYACRYLATE COATINGS; POTENTIAL EFFECTS; PROTEIN BINDING; UPTAKE KINETICS;

BIOCHEMISTRY; BODY FLUIDS; COATINGS; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PROTEINS; THICKNESS MEASUREMENT;

CONCENTRATION (PROCESS);

BOVINE SERUM ALBUMIN; CHLORPROMAZINE; POLYACRYLIC ACID;

AQUEOUS SOLUTION; ARTICLE; CONCENTRATION (PARAMETERS); DRUG DETERMINATION; DRUG PROTEIN BINDING; DRUG UPTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; MATERIAL COATING; NEGLIGIBLE DEPLETION SOLID PHASE MICROEXTRACTION; PRIORITY JOURNAL; SOLID PHASE MICROEXTRACTION; THICKNESS;

ABSORPTION; ACRYLIC RESINS; ANIMALS; CATTLE; CHLORPROMAZINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CULTURE MEDIA; DRUG EVALUATION, PRECLINICAL; KINETICS; PROTEIN BINDING; SERUM ALBUMIN, BOVINE; SOLID PHASE MICROEXTRACTION;

BOVINAE;

EID: 80054979537     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.09.064     Document Type: Article

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