T-cell signalling in antiretroviral-treated, aviraemic HIV-1-positive individuals is present in a raised state of basal activation that contributes to T-cell hyporesponsiveness

AIDS

Volumn 25, Issue 16, 2011, Pages 1981-1986

  Downey, Jocelyn S ^a   Attaf, Meriem ^a   Moyle, Graeme ^b   Gazzard, Brian ^b   Gotch, Frances ^a   Imami, Nesrina ^a  

^a CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

^b Chelsea and Wesminster Hospital   (United Kingdom)

Author keywords

c Jun N terminal kinases; extracellular signal regulated kinases; HIV; interleukin 2; phosphorylation; T cells; zeta chain associated protein kinase 70

Indexed keywords

ANTIRETROVIRUS AGENT; CD28 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; I KAPPA B KINASE BETA; INTERLEUKIN 2; LAT PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE ZAP 70; RNA; STRESS ACTIVATED PROTEIN KINASE; SUPPRESSOR OF CYTOKINE SIGNALING; SYNAPTOPHYSIN; T LYMPHOCYTE RECEPTOR;

ADULT; AGED; ARTICLE; BASAL CELL; CELL ACTIVATION; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; IMMUNE SYSTEM; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING; MALE; NERVE CELL MEMBRANE STEADY POTENTIAL; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PHOSPHORYLATION; PRIORITY JOURNAL; T LYMPHOCYTE;

ADULT; AGED; ANTI-HIV AGENTS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; FLOW CYTOMETRY; HIV INFECTIONS; HIV-1; HUMANS; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; PHENOTYPE; PHOSPHORYLATION; SIGNAL TRANSDUCTION; UP-REGULATION; VIRAL LOAD;

EID: 80054966953     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32834b35a9     Document Type: Article

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