Heat shock factor 4a (HSF4a) represses HSF2 expression and HSF2-mediated transcriptional activity

Journal of Cellular Physiology

Volumn 227, Issue 1, 2012, Pages 1-6

  Kim, Soo A ^a   Yoon, Jung Hoon ^b   Ahn, Sang Gun ^b  

^a Dongguk University   (South Korea)

^b Chosun University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK FACTOR 2; HEAT SHOCK FACTOR 4A; HEAT SHOCK PROTEIN 70; HEAT SHOCK TRANSCRIPTION FACTOR 1; HEMIN; MESSENGER RNA; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROCESSING; TRANSCRIPTION INITIATION;

DNA-BINDING PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEAT-SHOCK PROTEINS; HEAT-SHOCK RESPONSE; HEK293 CELLS; HEMIN; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; REAL-TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 80054965160     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22948     Document Type: Article

References (27)

1. Ahn SG, Kim SA, Yoon JH, Vacratsis P. 2005. Heat-shock cognate 70 is required for the activation of heat-shock factor 1 in mammalian cells. Biochem J 392:145-152.
2. Akerfelt M, Trouillet D, Mezger V, Sistonen L. 2007. Heat shock factors at a crossroad between stress and development. Ann NY Acad Sci 1113:15-27.
3. Baler R, Dahl G, Voellmy R. 1993. Activation of human heat shock genes is accompanied by oligomerization, modification, and rapid translocation of heat shock transcription factor HSF1. Mol Cell Biol 13:2486-2496.
4. Bjork JK, Sandqvist A, Elsing AN, Kotaja N, Sistonen L. 2010. miR-18, a member of Oncomir-1, targets heat shock transcription factor 2 in spermatogenesis. Development 137:3177-3184.
5. Frejtag W, Zhang Y, Dai R, Anderson MG, Mivechi NF. 2001. Heat shock factor-4 (HSF-4a) represses basal transcription through interaction with TFIIF. J Biol Chem 276:14685-14694.
6. Kavak E, Najafov A, Ozturk N, Seker T, Cavusoglu K, Aslan T, Duru AD, Saygili T, Hoxhaj G, Hiz MC, Unal DO, Birgul-Iyison N, Ozturk M, Koman A. 2010. Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets. Cell Signal 22:1523-1535.
7. Liu PC, Thiele DJ. 1999. Modulation of human heat shock factor trimerization by the linker domain. J Biol Chem 274:17219-17225.
8. Mathew A, Mathur SK, Morimoto RI. 1998. Heat shock response and protein degradation: Regulation of HSF2 by the ubiquitin-proteasome pathway. Mol Cell Biol 18:5091-5098.
9. Mathew A, Mathur SK, Jolly C, Fox SG, Kim S, Morimoto RI. 2001. Stress-specific activation and repression of heat shock factors 1 and 2. Mol Cell Biol 21:7163-7171.
10. Mezger V, Rallu M, Morimoto RI, Morange M, Renard JP. 1994. Heat shock factor 2-like activity in mouse blastocysts. Dev Biol 166:819-822.
11. Morano KA, Thiele DJ. 1999. Heat shock factor function and regulation in response to cellular stress, growth, and differentiation signals. Gene Expr 7:271-282.
12. Morimoto RI. 1998. Regulation of the heat shock transcriptional response: Cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes Dev 12:3788-3796.
13. Morimoto RI. 2008. Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes Dev 22:1427-1438.
14. Morimoto RI, Kroeger PE, Cotto JJ. 1996. The transcriptional regulation of heat shock genes: A plethora of heat shock factors and regulatory conditions. EXS 77:139-163.
15. Murphy SP, Gorzowski JJ, Sarge KD, Phillips B. 1994. Characterization of constitutive HSF2 DNA-binding activity in mouse embryonal carcinoma cells. Mol Cell Biol 14:5309-5317.
16. Nakai A, Kawazoe Y, Tanabe M, Nagata K, Morimoto RI. 1995. The DNA-binding properties of two heat shock factors, HSF1 and HSF3, are induced in the avian erythroblast cell line HD6. Mol Cell Biol 15:5268-5278.
17. Ostling P, Bjork JK, Roos-Mattjus P, Mezger V, Sistonen L. 2007. Heat shock factor 2 (HSF2) contributes to inducible expression of hsp genes through interplay with HSF1. J Biol Chem 282:7077-7086.
18. Pirkkala L, Nykanen P, Sistonen L. 2001. Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. FASEB J 15:1118-1131.
19. Rallu M, Loones M, Lallemand Y, Morimoto R, Morange M, Mezger V. 1997. Function and regulation of heat shock factor 2 during mouse embryogenesis. Proc Natl Acad Sci USA 94:2392-2397.
20. Sarge KD, Park-Sarge OK, Kirby JD, Mayo KE, Morimoto RI. 1994. Expression of heat shock factor 2 in mouse testis: Potential role as a regulator of heat-shock protein gene expression during spermatogenesis. Biol Reprod 50:1334-1343.
21. Sistonen L, Sarge KD, Phillips B, Abravaya K, Morimoto RI. 1992. Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells. Mol Cell Biol 12:4104-4111.
22. Sorger PK. 1991. Heat shock factor and the heat shock response. Cell 65:363-366.
23. Tanabe M, Sasai N, Nagata K, Liu XD, Liu PC, Thiele DJ, Nakai A. 1999. The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing. J Biol Chem 274:27845-27856.
24. Theodorakis NG, Zand DJ, Kotzbauer PT, Williams GT, Morimoto RI. 1989. Hemin-induced transcriptional activation of the HSP70 gene during erythroid maturation in K562cells is due to a heat shock factor-mediated stress response. Mol Cell Biol 9:3166-3173.
25. Wu C. 1995. Heat shock transcription factors: Structure and regulation. Annu Rev Cell Dev Biol 11:441-469.
26. Xing D, Shapley RM, Hawken MJ, Ringach DL. 2005. Effect of stimulus size on the dynamics of orientation selectivity in Macaque V1. J Neurophysiol 94:799-812.
27. Zhang Y, Frejtag W, Dai R, Mivechi NF. 2001. Heat shock factor-4 (HSF-4a) is a repressor of HSF-1 mediated transcription. J Cell Biochem 82:692-703.