Novel acylated steroidal glycosides from Caralluma tuberculata induce caspase-dependent apoptosis in cancer cells

Journal of Ethnopharmacology

Volumn 137, Issue 3, 2011, Pages 1189-1196

  Waheed, Abdul ^a   Barker, James ^a   Barton, Stephen J ^a   Khan, Gul Majid ^b   Najm Us Saqib, Qazi ^c   Hussain, Manzoor ^d   Ahmed, Sabbir ^e   Owen, Caroline ^e   Carew, Mark A ^a  

^a KINGSTON UNIVERSITY   (United Kingdom)

^b GOMAL UNIVERSITY   (Pakistan)

^c Department of Pharmaceutical Sciences   (Pakistan)

^d HAZARA UNIVERSITY   (Pakistan)

^e UNIVERSITY OF THE WEST OF SCOTLAND   (United Kingdom)

Author keywords

Androstan glycosides; Asclepiadaceae; Breast cancer; Caralluma tuberculata; MTT assay; Neutral red uptake assay; Pregnane glycosides

Indexed keywords

12 O BENZOYL 20 O ACETYL 3BETA,12BETA,14BETA,20BETA TETRAHYDROXY PREGNAN 3 YL O BETA DEXTRO GLUCOPYRANOSYL (1-4) BETA DEXTRO GLUCOPYRANOSYL (1-4) 3 ETHOXY BETA DEXTRO RIBOPYRANOSIDE; 4',6 DIAMIDINO 2 PHENYLINDOLE; ACETIC ACID ETHYL ESTER; ANASTROZOLE; ANDROSTANE DERIVATIVE; ANTINEOPLASTIC AGENT; DACTINOMYCIN; NEUTRAL RED; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; TAMOXIFEN; UNCLASSIFIED DRUG;

ADSORPTION CHROMATOGRAPHY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CARALLUMA TUBERCULATA; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN CACO 2; CELL STRAIN MCF 7; CELL STRAIN U937; CELL VIABILITY; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG DESIGN; DRUG EFFICACY; DRUG ISOLATION; FEMALE; FRACTIONATION; HETERONUCLEAR MULTIPLE BOND CORRELATION; HUMAN; HUMAN CELL; MEDICINAL PLANT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CLEAVAGE; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; TIME OF FLIGHT MASS SPECTROMETRY; TREATMENT RESPONSE; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING;

ACYLATION; AMINO ACID CHLOROMETHYL KETONES; ANDROSTANOLS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; ASCLEPIADACEAE; BLOTTING, WESTERN; CACO-2 CELLS; CASPASES; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL FRACTIONATION; CHROMATOGRAPHY; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOSIDES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR STRUCTURE; NEOPLASMS; PLANTS, MEDICINAL; POLY(ADP-RIBOSE) POLYMERASES; PREGNANES; STRUCTURE-ACTIVITY RELATIONSHIP; U937 CELLS;

APOCYNACEAE; CARALLUMA;

EID: 80054956494     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.07.049     Document Type: Article

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