Sulf2 gene is alternatively spliced in mammalian developing and tumour tissues with functional implications

Biochemical and Biophysical Research Communications

Volumn 414, Issue 3, 2011, Pages 468-473

  Gill, Rai B S ^a   Day, Amy ^a   Barstow, Amy ^a   Liu, Hongxiang ^b   Zaman, Gul ^a   Dhoot, Gurtej K ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Alternative splicing; CMet; EGFR; Fetal development; PAKT; PERK; Sulf2; Tumour growth

Indexed keywords

EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SCATTER FACTOR; SULFATASE; SULFATASE 1; SULFATASE 2; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; DOWNSTREAM PROCESSING; GENE DELETION; HUMAN; HUMAN TISSUE; LUNG TUMOR; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR GROWTH;

ALTERNATIVE SPLICING; ANIMALS; CHICK EMBRYO; DOGS; EXONS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG; LUNG NEOPLASMS; MICE; SIGNAL TRANSDUCTION; SULFOTRANSFERASES;

AVES; MAMMALIA;

EID: 80054955844     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.09.088     Document Type: Article

References (19)

1. Dhoot G.K., Gustafsson M.K., Ai X., Sun W., Standiford D.M., Emerson C.P. Regulation of Wnt signaling and embryo patterning by an extracellular sulfatase. Science 2001, 293:1663-1666.
2. Morimoto-Tomita M., Uchimura K., Werb Z., Hemmerich S., Rosen S.D. Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. J. Biol. Chem. 2002, 2771:49175-49185.
3. Ai X., Do A.T., Lozynska O., Kusche-Gullberg M., Lindahl U., Emerson C.P. QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signaling. J. Cell Biol. 2003, 162:341-351.
4. Nawroth R., van Zante A., Cervantes S., McManus M., Hebrok M., Rosen S.D. Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells. PLoS One 2007, 2(4):e392.
5. Wang S., Ai X., Freeman S.D., Pownall M.E., Lu Q., Kessler D.S., Emerson C.P. QSulf1, a heparan sulfate 6-O-endosulfatase, inhibits fibroblast growth factor signaling in mesoderm induction and angiogenesis. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:4833-4848.
6. Lai J.P., Chien J., Staub J., Avula R., Greene E.L., Matthews T.A., Smith D.I., Kaufman S.H., Roberts L.R., Shridhar V. Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer. J. Biol. Chem. 2003, 278:23107-23117.
7. Lai J.P., Chien J., Strome J.S.E., Staub J., Montoya D.P., Greene E.L., Smith D.I., Roberts L.R., Shridhar V. HSulf-1 modulates HGF-mediated tumor cell invasion and signaling in head and neck squamous carcinoma. Oncogene 2004, 23:1439-1447.
8. Ai X., Kitazawa T., Do A.T., Kusche-Gullberg M., Labosky P.A., Emerson C.P. SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation. Development 2007, 134:3327-3338.
9. Sahota A.P., Dhoot G.K. A novel SULF1 splice variant inhibits Wnt signalling but enhances angiogenesis by opposing SULF1 activity. Exp. Cell Res. 2009, 315:2752-2764.
10. Rosen S.D., Lemjabbar-Alaoui H. Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate. Expert. Opin. Ther. Targets 2010, 14:935-949.
11. Yang J.D., Sun Z., Hu C., Lai J., Dove R., Nakamura I., Lee J.S., Thorgeirsson S.S., Kang K.J., Chu I.S., Roberts L.R. Sulfatase 1 and sulfatase 2 in hepatocellular carcinoma: associated signaling pathways, tumor phenotypes, and survival. Genes Chromos. Cancer 2011, 50:122-135.
12. Bret C., Moreaux J., Schved J.F., Hose D., Klein B. SULFs in human neoplasia: implication as progression and prognosis factors. J. Transl. Med. 2011, 9:72. 10.1186/1479-58769-7.
13. Armstrong V.J., Muzylak M., Sunters A., Zaman G., Saxon L.K., Price J.S., Lanyon L.E. Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha. J. Biol. Chem. 2007, 282:20715-20727.
14. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
15. Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. 1979, 76:4350-4354.
16. Gill R., Hitchins L., Fletcher F., Dhoot G.K. Sulf1A and HGF regulate satellite-cell growth. J. Cell Sci. 2010, 123:1873-1883.
17. Knaust A., Schmidt B., Dierks T., von Bulow R., von Figura K. Residues critical for formylglycine formation and/or catalytic activity of arylsulfatase A. Biochemistry 1998, 37:13941-13946.
18. Matsubara D., Ishikawa S., Sachiko O., Aburatani H., Fukayama M., Niki T. Co-activation of epidermal growth factor receptor and c-MET defines a distinct subset of lung adenocarcinomas. Am. J. Pathol. 2010, 177:2191-2204.
19. Song J., Li M., Tretiakova M., Salgia R., Cagle P.T., Husain A.N. Expression patterns of PAX5, c-Met, and paxillin in neuroendocrine tumors of the lung. Arch. Pathol. Lab Med. 2010, 134:1702-1705.