In vivo bioluminescence imaging of tumor hypoxia dynamics of breast cancer brain metastasis in a mouse model

Journal of Visualized Experiments

Volumn , Issue 56, 2011, Pages

  Saha, Debabrata ^a   Dunn, Henry ^a   Zhou, Heling ^a   Harada, Hiroshi ^b   Hiraoka, Masahiro ^b   Mason, Ralph P ^a   Zhao, Dawen ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

(HIF 1 945; ); Bioluminescence imaging (BLI); Breast cancer brain metastasis; Hypoxia inducible factor 1 945; ; Issue 56; Medicine; Tumor hypoxia dynamics

Indexed keywords

EID: 80054951634     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/3175     Document Type: Article

References (12)

1. Harada, H., et al. The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts. Biochem Biophys Res Commun. 360 (4), 791-796 (2007).
2. Ou, G., et al. Usefulness of HIF-1 imaging for determining optimal timing of combining bevacizumab and radiotherapy. Int J Radiat Oncol Biol Phys. 75 (2), 463-467 (2009).
3. Zhou, H., et al. Dynamic near-infrared optical imaging of 2-deoxyglucose uptake by intracranial glioma of athymic mice. PLoS One. 4 (11), e8051 (2009).
4. Contero, A., Richer, E., Gondim, A., & Mason, R.P. High-throughput quantitative bioluminescence imaging for assessing tumor burden. Methods Mol Biol. 574, 37-45 (2009).
5. Zhao, D., Richer, E., Antich, P.P., & Mason, R.P. Antivascular effects of combretastatin A4 phosphate in breast cancer xenograft assessed using dynamic bioluminescence imaging and confirmed by MRI. FASEB J. 22, 2245-2451 (2008).
6. Chang, E.L. & Lo, S., Diagnosis and management of central nervous system metastases from breast cancer. Oncologist. 8 (5), 398-410 (2003).
7. Palmieri, D., et al. Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks. Clin Cancer Res. 15 (19), 6148-6157 (2009).
8. Mason, R.P., et al. Multimodality imaging of hypoxia in preclinical settings. Q J Nucl Med Mol Imaging. 54 (3), 259-280 (2010).
9. Tatum, J.L., et al. Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int J Radiat Biol. 82 (10), 699-757 (2006).
10. Moeller, B.J., et al. Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Cancer Cell. 8 (2), 99-110 (2005).
11. Lu, X., et al. In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer. Cancer Res. 70 (10), 3905-3914 (2010).
12. Zhao, D., Chang, C.H., Kim, J.G., Liu, H., & Mason, R.P. In vivo Near-Infrared Spectroscopy and Magnetic Resonance Imaging Monitoring of Tumor Response to Combretastatin A-4-Phosphate Correlated With Therapeutic Outcome. Int J Radiat Oncol Biol Phys. 80 (2), 574-81 (2011).