Amide isosteres in structure-activity studies of antibacterial minor groove binders

European Journal of Medicinal Chemistry

Volumn 46, Issue 11, 2011, Pages 5343-5355

  Khalaf, Abedawn I ^a   Anthony, Nahoum ^a   Breen, David ^a   Donoghue, Gavin ^a   MacKay, Simon P ^a   Scott, Fraser J ^a   Suckling, Colin J ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Antibacterial activity; Diazene isosteres; DNA; Minor groove binders

Indexed keywords

1 ISOPROPYL 4 [[[1 METHYL 4 [[4 [2 (3 QUINOLINYL)ETHENYL]BENZOYL]AMINO] 1H PYRROL 2 YL]CARBONYL]AMINO] N [2 (4 MORPHOLINYL)ETHYL] 1H PYRROLE 2 CARBOXAMIDE; 1 METHYL N [1 METHYL 5 [[[2 (4 MORPHOLINYL)ETHYL]AMINO]CARBONYL] 1H PYRROL 3 YL] 4 ([4 [3 QUINOLINYLDIAZENYL]BENZOYL]AMINO) 1H PYRROLE 2 CARBOXAMIDE; 1 SEC BUTYL 4 [[[1 METHYL 4 [[4 [2 (3 QUINOLINYL)ETHENYL]BENZOYL]AMINO] 1H PYRROL 2 YL]CARBONYL]AMINO] N [2 (4 MORPHOLINYL)ETHYL] 1H PYRROLE 2 CARBOXAMIDE; 4 (3 QUINOLINYLDIAZENYL)BENZOIC ACID; 4 [(4 [2 [4 (DIMETHYLAMINO)PHENYL]ETHENYL]BENZOYL]AMINO] 1 METHYL N [1 METHYL 5 [[[2 (4 MORPHOLINYL)ETHYL] AMINO]CARBONYL] 1H PYRROL 3 YL] 1H PYRROLE 2 CARBOXAMIDE; 4 [[4 [[4 (DIMETHYLAMINO)BENZOYL]AMINO]BENZOYL]AMINO] 1 METHYL N [1 METHYL 5 [[[2 (4 MORPHOLINYL)ETHYL]AMINO]CARBONYL] 1H PYRROL 3 YL] 1H PYRROLE 2 CARBOXAMIDE; 4 [[4 [[4 (DIMETHYLAMINO)PHENYL]DIAZENYL]BENZOYL]AMINO] 1 METHYL N [1 METHYL 5 [[[2 (4 MORPHOLINYL)ETHYL]AMINO]CARBONYL] 1H PYRROL 3 YL] 1H PYRROLE 2 CARBOXAMIDE; 4 [[[1 ISOPROPYL 4 [[4 [2 (3 QUINOLINYL)ETHENYL]BENZOYL]AMINO] 1H PYRROL 2 YL]CARBONYL]AMINO] 1 METHYL N [2 (4 MORPHOLINYL)ETHYL] 1H PYRROLE 2 CARBOXAMIDE; 4 [[[1 SEC BUTYL 4 [[4 [2 (3 QUINOLINYL)ETHENYL]BENZOYL]AMINO] 1H PYRROL 2 YL]CARBONYL]AMINO] 1 METHYL N [2 (4 MORPHOLINYL)ETHYL] 1H PYRROLE 2 CARBOXAMIDE; ALKENE DERIVATIVE; AMIDE; ANTIINFECTIVE AGENT; DNA; N [1 ISOPROPYL 5 [[[1 METHYL 5 [[[2 (4 MORPHOLINYL)ETHYL]AMINO]CARBONYL] 1H PYRROL 3 YL]AMINO]CARBONYL] 1H PYRROL 3 YL] 6 [2 (4 METHOXYPHENYL)ETHENYL]NICOTINAMIDE; N [1 SEC BUTYL 5 [[[1 METHYL 5 [[[2 (4 MORPHOLINYL)ETHYL]AMINO]CARBONYL] 1H PYRROL 3 YL]AMINO]CARBONYL] 1H PYRROL 3 YL] 6 [2 (4 METHOXYPHENYL)ETHENYL]NICOTINAMIDE; N [4 [[[1 METHYL 5 [[[1 METHYL 5 [[[2 (4 MORPHOLINYL)ETHYL]AMINO]CARBONYL] 1H PYRROL 3 YL]AMINO]CARBONYL] 1H PYRROL 3 YL]AMINO]CARBONYL)PHENYL] 3 QUINOLINE CARBOXAMIDE; N [5 [[[1 ISOPROPYL 5 [[[2 (4 MORPHOLINYL)ETHYL]AMINO]CARBONYL] 1H PYRROL 3 YL]AMINO]CARBONYL) 1 METHYL 1H PYRROL 3 YL] 6 [2 (4 METHOXYPHENYL)ETHENYL]NICOTINAMIDE; N [5 [[[1 SEC BUTYL 5 [[[2 (4 MORPHOLINYL)ETHYL]AMINO]CARBONYL] 1H PYRROL 3 YL]AMINO]CARBONYL] 1 METHYL 1H PYRROL 3 YL] 6 [2 (4 METHOXYPHENYL)ETHENYL]NICOTINAMIDE; POLYAMIDE; PROPANE; PYRROLE DERIVATIVE; QUINOLINE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; ASPERGILLUS NIGER; CANDIDA ALBICANS; DNA BINDING; ENTEROCOCCUS FAECALIS; MYCOBACTERIUM AURUM; NONHUMAN; STAPHYLOCOCCUS AUREUS; TUBERCULOSIS;

ALKANES; AMIDES; ANTI-BACTERIAL AGENTS; BACTERIA; DNA; DRUG DESIGN; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80054937485     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.08.035     Document Type: Article

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