Selective inhibition of DNA gyrase in vitro by a GC specific eight-ring hairpin polyamide at nanomolar concentration

FEBS Letters

Volumn 471, Issue 2-3, 2000, Pages 173-176

  Simon, H ^a   Kittler, L ^b   Baird, E ^c   Dervan, P ^c   Zimmer, C ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b FRITZ LIPMANN INSTITUTE   (Germany)

^c California Institute of Technology ^*  (United States)

Author keywords

DNA gyrase; Inhibition; Minor groove binder

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); ENZYME INHIBITOR; POLYAMIDE;

ARTICLE; DNA CLEAVAGE; ENZYME INHIBITION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL;

BASE SEQUENCE; BINDING SITES; DEOXYRIBONUCLEASE I; DNA; DNA FOOTPRINTING; DNA TOPOISOMERASES, TYPE II; DNA, SUPERHELICAL; ESCHERICHIA COLI; INHIBITORY CONCENTRATION 50; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; NYLONS; PLASMIDS; REGULATORY SEQUENCES, NUCLEIC ACID; STREPTOMYCES; SUBSTRATE SPECIFICITY;

EID: 0034647098     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(00)01390-9     Document Type: Article

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