Development of N-[3-(2',4'-dichlorophenoxy)-2-18F-fluoropropyl]-N-methylpropargylamine (18F-fluoroclorgyline) as a potential PET radiotracer for monoamine oxidase-A

Nuclear Medicine and Biology

Volumn 26, Issue 6, 1999, Pages 619-625

  Mukherjee, Jogeshwar ^a   Yang, Zhi Ying ^a  

^a Franklin McLean Memorial Research Institute   (United States)

Author keywords

18F Fluoroclorgyline; Fluorine 18; Monoamine oxidase A

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; CLORGYLINE; ENZYME; FLUORINE 18; N (2 AMINOETHYL) 5 (3 FLUOROPHENYL) 4 THIAZOLECARBOXAMIDE; TRACER;

ANIMAL TISSUE; ARTICLE; BRAIN MEMBRANE; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOCHEMISTRY; RAT;

ANIMALS; BRAIN; CLORGYLINE; FLUORINE RADIOISOTOPES; KINETICS; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; SELEGILINE; THIAZOLES; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0032833323     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(99)00027-X     Document Type: Article

References (18)

1. 11C-labeled MAO-A inhibitors and their in vivo uptake kinetics in rhesus monkey brain. Nucl. Med. Biol. 24:1997;381-388.
2. 11C-Harmine as a tracer for monoamine oxidase A (MAO-A) In vitro and in vivo studies . Nucl. Med. Biol. 24:1997;287-293.
3. 11C-labeled suicide inactivators and PET. Science. 235:1987;481-485.
4. Hirata M., Magata Y., Ohmono Y., Saji H., Murakami K., Takagaki T., Yamamura N., Tanaka C., Konishi J., Yokoyama A. Evaluation of radioiodinated iodoclorgyline as a SPECT radiopharmaceutical for MAO-A in the brain. Nucl. Med. Biol. 22:1995;175-180.
5. Hirata M., Magata Y., Ohmono Y., Saji H., Tanaka C., Yokoyama A. Radiofluorinated clorgyline derivative for mapping MAO-A activity in brain with PET. J. Labelled Compd. Radiopharm. 35:1994;234-235.
6. Johnston J.P. Some observations upon a new inhibitor of monoamine oxidase in brain tissue. Biochem. Pharmacol. 17:1968;1285-1297.
7. Knoll J., Magyar K. Some puzzling pharmacological effects of monoamine oxidase inhibitors. Adv. Biochem. Psychopharmacol. 5:1972;393-408.
8. 11C]-L-deprenyl in mice Potential for measurement of functional monoamine oxidase activity in brain using positron emission tomography . Biochem. Pharmacol. 34:1985;3207-3210.
9. Munson P.J., Rodbard D. LIGAND A versatile approach for the characterisation of ligand binding systems . Anal. Biochem. 107:1980;220-239.
10. 14C-clorgyline autoradiography. Nucl. Med. Biol. 19:1992;619-626.
11. O'Brien E.M., Tipton K.F., Meroni M., Dostert P. Inhibition of monoamine oxidase by clorgyline analogues. J. Neural Trans. 41:(suppl.):1994;295-305.
12. Ohmono Y., Hirata M., Murakami K., Magata Y., Tanaka C., Yokoyama A. Synthesis of fluorine and iodine analogues of clorgyline and selective inhibition of monoamine oxidase A. Chem. Pharm. Bull. 39:1991;1038-1040.
13. 125I]iodoclorgyline, a selective monoamine oxidase A inhibitor, and its biodistribution in mice. Chem. Pharm. Bull. 39:1991;3343-3345.
14. 11C]fluoroclorgyline A monoamine oxidase A specific inhibitor for positron emission tomography . Chem. Pharm. Bull. 41:1993;1994-1997.
15. 3H]Ro 19-6327 in vitro Localization and abundance of MAO-A and MAO-B in rat CNS, peripheral organs, and human brain . J. Neurosci. 12:1992;1977-1999.
16. Walsh C. (1979) Enzymatic Reaction Mechanisms, Enzymatic Reaction Mechanisms, pp. 402-405. W.H. Freeman and Company, San Francisco.
17. Yu P.H., Davies B.A., Boulton A.A. Aliphatic propargylamines Potent, selective, irreversible monoamine oxidase B inhibitors . J. Med. Chem. 35:1992;3705-3713.
18. Yu P.H., Davies B.A., Boulton A.A. Effect of structural modification of alkyl N- propargylamines on the selective inhibition of monoamine oxidase B activity. Biochem. Pharmacol. 46:1993;753-757.