Cytokine expression in the seminal plasma and its effects on fertilisation rates in an IVF cycle

Andrologia

Volumn 43, Issue 6, 2011, Pages 378-386

  Seshadri, S ^a   Bates, M ^b   Vince, G ^c   Lewis Jones, D I ^d  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^c LANCASTER UNIVERSITY   (United Kingdom)

^d LIVERPOOL WOMEN S HOSPITAL   (United Kingdom)

Author keywords

Cytokines; Fertilisation rates; In vitro fertilisation

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 11; INTERLEUKIN 12; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CELL INTERACTION; CLINICAL ARTICLE; FERTILIZATION; FERTILIZATION IN VITRO; HUMAN; MALE; MALE INFERTILITY; OOCYTE; PROTEIN EXPRESSION; SEMINAL PLASMA; SPERMATOZOON;

ADULT; CYTOKINES; FEMALE; FERTILIZATION; FERTILIZATION IN VITRO; HUMANS; MALE; MIDDLE AGED; PREGNANCY; PREGNANCY RATE; PROSPECTIVE STUDIES; SEMEN;

EID: 80054932255     PISSN: 03034569     EISSN: 14390272     Source Type: Journal    
DOI: 10.1111/j.1439-0272.2010.01042.x     Document Type: Article

References (52)

1. Alvarez JG, Sharma RK, Ollero M, Saleh RA, Lopez MC, Thomas AJ Jr, Evenson DP, Agarwal A (2002) Increased DNA damage in sperm from leukocytospermic semen samples as determined by the sperm chromatin structure assay. Fertil Steril 78:319-329.
2. Aziz N, Saleh RA, Sharma RK, Lewis-Jones I, Esfandiari N, Thomas AJ Jr, Agarwal A (2004) Novel association between sperm reactive oxygen species production, sperm morphological defects, and the sperm deformity index. Fertil Steril 81:349-354.
3. Ben-Chetrit A, Senoz S, Greenblatt EM, Casper RF (1995) In vitro fertilization outcome in the presence of severe male factor infertility. Fertil Steril 63:1032-1037.
4. Brackett NL, Cohen DR, Ibrahim E, Aballa TC, Lynne CM (2007) Neutralization of cytokine activity at the receptor level improves sperm motility in men with spinal cord injuries. J Androl 28:717-721.
5. Chaouat G, Ledee-Bataille N, Chea KB, Dubanchet S (2005) Cytokines and implantation. Chem Immunol Allergy 88:34-63.
6. Comhaire FH, Mahmoud AM, Depuydt CE, Zalata AA, Christophe AB (1999) Mechanisms and effects of male genital tract infection on sperm quality and fertilizing potential: the andrologist's viewpoint. Hum Reprod Update 5:393-398.
7. Diemer T, Hales DB, Weidner W (2003) Immune-endocrine interactions and Leydig cell function: the role of cytokines. Andrologia 35:55-63.
8. Donnelly ET, Lewis SE, McNally JA, Thompson W (1998) In vitro fertilization and pregnancy rates: the influence of sperm motility and morphology on IVF outcome. Fertil Steril 70:305-314.
9. Dousset B, Hussenet F, Daudin M, Bujan L, Foliguet B, Nabet P (1997) Seminal cytokine concentrations (IL-1beta, IL-2, IL-6, sR IL-2, sR IL-6), semen parameters and blood hormonal status in male infertility. Hum Reprod 12:1476-1479.
10. Eggert-Kruse W, Gerhard I, Tilgen W, Runnebaum B (1989) Clinical significance of crossed in vitro sperm-cervical mucus penetration test in infertility investigation. Fertil Steril 52:1032-1040.
11. Eggert-Kruse W, Boit R, Rohr G, Aufenanger J, Hund M, Strowitzki T (2001) Relationship of seminal plasma interleukin (IL) -8 and IL-6 with semen quality. Hum Reprod 16:517-528.
12. Eggert-Kruse W, Kiefer I, Beck C, Demirakca T, Strowitzki T (2007) Role for tumor necrosis factor alpha (TNF-alpha) and interleukin 1-beta (IL-1beta) determination in seminal plasma during infertility investigation. Fertil Steril 87:810-823.
13. Eisermann J, Register KB, Strickler RC, Collins JL (1989) The effect of tumor necrosis factor on human sperm motility in vitro. J Androl 10:270-274.
14. Estrada LS, Champion HC, Wang R, Rajasekaran M, Hellstrom WJ, Aggarwal B, Sikka SC (1997) Effect of tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on human sperm motility, viability and motion parameters. Int J Androl 20:237-242.
15. Fedder J, Ellerman-Eriksen S (1995) Effect of cytokines on sperm motility and ionophore-stimulated acrosome reaction. Arch Androl 35:173-185.
16. Friebe K, Bohring C, Skrzypek J, Krause W (2003) Levels of interleukin-6 and interleukin-8 in seminal fluid of men attending an andrological clinic. Andrologia 35:126-129.
17. Gruschwitz MS, Brezinschek R, Brezinschek HP (1996) Cytokine levels in the seminal plasma of infertile males. J Androl 17:158-163.
18. Heinrich PC, Behrmann I, Muller-Newen G, Schaper F, Graeve L (1998) Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J 334:297-314.
19. Hill JA, Haimovici F, Politch JA, Anderson DJ (1987) Effects of soluble products of activated lymphocytes and macrophages (lymphokines and monokines) on human sperm motion parameters. Fertil Steril 47:460-465.
20. Hill JA, Cohen J, Anderson DJ (1989) The effects of lymphokines and monokines on human sperm fertilizing ability in the zona-free hamster egg penetration test. Am J Obstet Gynecol 160:1154-1159.
21. Howard M, O'Garra A, Ishida H, de Waal MR, de VJ (1992) Biological properties of interleukin 10. J Clin Immunol 12:239-247.
22. Huleihel M, Lunenfeld E, Horowitz S, Levy A, Potashnik G, Mazor M, Glezerman M (1999) Expression of IL-12, IL-10, PGE2, sIL-2R and sIL-6R in seminal plasma of fertile and infertile men. Andrologia 31:283-288.
23. Hussenet F, Dousset B, Cordonnier JL, Jacob C, Foliguet B, Grignon G, Nabet P (1993) Tumour necrosis factor alpha and interleukin 2 in normal and infected human seminal fluid. Hum Reprod 8:409-411.
24. Jedrzejczak P, Fraczek M, Szumala-Kakol A, Taszarek-Hauke G, Pawelczyk L, Kurpisz M (2005) Consequences of semen inflammation and lipid peroxidation on fertilization capacity of spermatozoa in in vitro conditions. Int J Androl 28:275-283.
25. Kocak I, Yenisey C, Dundar M, Okyay P, Serter M (2002) Relationship between seminal plasma interleukin-6 and tumor necrosis factor alpha levels with semen parameters in fertile and infertile men. Urol Res 30:263-267.
26. Koumantakis E, Matalliotakis I, Kyriakou D, Fragouli Y, Relakis K (1998) Increased levels of interleukin-8 in human seminal plasma. Andrologia 30:339-343.
27. Leutscher PD, Pedersen M, Raharisolo C, Jensen JS, Hoffmann S, Lisse I, Ostrowski SR, Reimert CM, Mauclere P, Ullum H (2005) Increased prevalence of leukocytes and elevated cytokine levels in semen from Schistosoma haematobium-infected individuals. J Infect Dis 191:1639-1647.
28. Matalliotakis I, Kiriakou D, Fragouli I, Sifakis S, Eliopoulos G, Koumantakis E (1998a) Interleukin-6 in seminal plasma of fertile and infertile men. Arch Androl 41:43-50.
29. Matalliotakis I, Kyriakou D, Fragouli Y, Loutradis D, Goumenou A, Koumantakis E (1998b) Determination of interleukin-11 in seminal plasma and elevated IL-11 in seminal plasma of infertile patients with urogenital infection. Arch Androl 41:177-183.
30. Matalliotakis I, Arici A, Goumenou A, Koumantakis G, Selam B, Matalliotakis G, Koumantakis E (2002) Distinct expression pattern of cytokines in semen of men with genital infection and oligo-terato-asthenozoospermia. Am J Reprod Immunol 48:170-175.
31. Miller KF, Falcone T, Goldberg JM (1996) Variation in recovery of motile sperm after preparation by a simple Percoll gradient technique. J Assist Reprod Genet 13:485-488.
32. Motro B, Itin A, Sachs L, Keshet E (1990) Pattern of interleukin 6 gene expression in vivo suggests a role for this cytokine in angiogenesis. Proc Natl Acad Sci USA 87:3092-3096.
33. Naz RK, Evans L (1998) Presence and modulation of interleukin-12 in seminal plasma of fertile and infertile men. J Androl 19:302-307.
34. Naz RK, Kaplan P (1994a) Increased levels of interleukin-6 in seminal plasma of infertile men. J Androl 15:220-227.
35. Naz RK, Kaplan P (1994b) Interleukin-6 enhances the fertilizing capacity of human sperm by increasing capacitation and acrosome reaction. J Androl 15:228-233.
36. Naz RK, Evans L, Armstrong JS, Sikka SC (1998) Decreased levels of interleukin-12 are not correlated with leukocyte concentration and superoxide dismutase activity in semen of infertile men. Arch Androl 41:91-96.
37. O'Leary S, Jasper MJ, Warnes GM, Armstrong DT, Robertson SA (2004) Seminal plasma regulates endometrial cytokine expression, leukocyte recruitment and embryo development in the pig. Reproduction 128:237-247.
38. Orava M, Cantell K, Vihko R (1986) Treatment with preparations of human leukocyte interferon decreases serum testosterone concentrations in men. Int J Cancer 38:295-296.
39. Paradisi R, Capelli M, Mandini M, Bellavia E, Flamigni C (1996) Increased levels of interferon-gamma in seminal plasma of infertile men. Andrologia 28:157-161.
40. Paul WE, Seder RA (1994) Lymphocyte responses and cytokines. Cell 76:241-251.
41. Politch JA, Tucker L, Bowman FP, Anderson DJ (2007) Concentrations and significance of cytokines and other immunologic factors in semen of healthy fertile men. Hum Reprod 22:2928-2935.
42. Rajasekaran M, Hellstrom WJ, Naz RK, Sikka SC (1995) Oxidative stress and interleukins in seminal plasma during leukocytospermia. Fertil Steril 64:166-171.
43. Rajasekaran M, Hellstrom W, Sikka S (1996) Quantitative assessment of cytokines (GRO alpha and IL-10) in human seminal plasma during genitourinary inflammation. Am J Reprod Immunol 36:90-95.
44. Seshadri S, Bates M, Vince G, Jones DI (2009) The role of cytokine expression in different subgroups of subfertile men. Am J Reprod Immunol 62:275-282.
45. Shimoya K, Matsuzaki N, Tsutsui T, Taniguchi T, Saji F, Tanizawa O (1993) Detection of interleukin-8 (IL-8) in seminal plasma and elevated IL-8 in seminal plasma of infertile patients with leukospermia. Fertil Steril 59:885-888.
46. Sukcharoen N, Keith J, Irvine DS, Aitken RJ (1995) Predicting the fertilizing potential of human sperm suspensions invitro: importance of sperm morphology and leukocyte contamination. Fertil Steril 63:1293-1300.
47. Trinchieri G (1993) Interleukin-12 and its role in the generation of TH1 cells. Immunol Today 14:335-338.
48. Wang H, Dey SK (2006) Roadmap to embryo implantation: clues from mouse models. Nat Rev Genet 7:185-199.
49. Watson JM, Sensintaffar JL, Berek JS, Martinez-Maza O (1990) Constitutive production of interleukin 6 by ovarian cancer cell lines and by primary ovarian tumor cultures. Cancer Res 50:6959-6965.
50. Wincek TJ, Meyer TK, Meyer MR, Kuehl TJ (1991) Absence of a direct effect of recombinant tumor necrosis factor-alpha on human sperm function and murine preimplantation development. Fertil Steril 56:332-339.
51. Zalata A, Hafez T, Van Hoecke MJ, Comhaire F (1995) Evaluation of beta-endorphin and interleukin-6 in seminal plasma of patients with certain andrological diseases. Hum Reprod 10:3161-3165.
52. Zolti M, Ben-Rafael Z, Meirom R, Shemesh M, Bider D, Mashiach S, Apte RN (1991) Cytokine involvement in oocytes and early embryos. Fertil Steril 56:265-272.