Do patients with aggressive periodontitis have evidence of diabetes? A pilot study

Journal of Periodontal Research

Volumn 46, Issue 6, 2011, Pages 663-672

  Davies, R C ^a   Jaedicke, K M ^a   Barksby, H E ^a   Jitprasertwong, P ^a   Al Shahwani, R M ^a   Taylor, J J ^a   Preshaw, P M ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Adipokine; Aggressive periodontitis; Diabetes; Periodontal disease

Indexed keywords

ADIPOCYTOKINE; AUTACOID; CYTOKINE; GLYCOSYLATED HEMOGLOBIN; LIPID;

ADOLESCENT; ADULT; AGGRESSIVE PERIODONTITIS; ALVEOLAR BONE LOSS; ARTICLE; BLOOD; CASE CONTROL STUDY; DIABETES MELLITUS; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; MALE; MIDDLE AGED; NONPARAMETRIC TEST; PILOT STUDY; RADIOGRAPHY; STATISTICAL MODEL;

ADIPOKINES; ADOLESCENT; ADULT; AGGRESSIVE PERIODONTITIS; ALVEOLAR BONE LOSS; BLOOD GLUCOSE; CASE-CONTROL STUDIES; CYTOKINES; DIABETES COMPLICATIONS; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INFLAMMATION MEDIATORS; LINEAR MODELS; LIPIDS; MALE; MIDDLE AGED; PILOT PROJECTS; STATISTICS, NONPARAMETRIC; YOUNG ADULT;

EID: 80054912362     PISSN: 00223484     EISSN: 16000765     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2011.01388.x     Document Type: Article

References (72)

1. Armitage GC, Cullinan MP, Seymour GJ. Comparative biology of chronic and aggressive periodontitis: introduction. Periodontol 2000 2010;53:7-11.
2. Taylor GW, Borgnakke WS. Periodontal disease: associations with diabetes, glycemic control and complications. Oral Dis 2008;14:191-203.
3. Buhlin K, Hultin M, Norderyd O et al. Risk factors for atherosclerosis in cases with severe periodontitis. J Clin Periodontol 2009;36:541-549.
4. Hayashida H, Kawasaki K, Yoshimura A et al. Relationship between periodontal status and HbA1c in nondiabetics. J Public Health Dent 2009;69:204-206.
5. Nibali L, D'Aiuto F, Griffiths G, Patel K, Suvan J, Tonetti MS. Severe periodontitis is associated with systemic inflammation and a dysmetabolic status: a case-control study. J Clin Periodontol 2007;34:931-937.
6. Oliver RC, Tervonen T. Diabetes-a risk factor for periodontitis in adults? J Periodontol 1994;65:530-538.
7. Iwamoto Y, Nishimura F, Nakagawa M et al. The effect of antimicrobial periodontal treatment on circulating tumor necrosis factor-alpha and glycated hemoglobin level in patients with type 2 diabetes. J Periodontol 2001;72:774-778.
8. Kiran M, Arpak N, Unsal E, Erdogan MF. The effect of improved periodontal health on metabolic control in type 2 diabetes mellitus. J Clin Periodontol 2005;32:266-272.
9. Lopez NJ, Valenzuela CY, Jara L. Interleukin-1 gene cluster polymorphisms associated with periodontal disease in type 2 diabetes. J Periodontol 2009;80:1590-1598.
10. Preshaw PM, Foster N, Taylor JJ. Cross-susceptibility between periodontal disease and type 2 diabetes mellitus: an immunobiological perspective. Periodontol 2000 2007;45:138-157.
11. Cutler CW, Shinedling EA, Nunn M et al. Association between periodontitis and hyperlipidemia: cause or effect? J Periodontol 1999;70:1429-1434.
12. D'Aiuto F, Parkar M, Brett PM, Ready D, Tonetti MS. Gene polymorphisms in pro-inflammatory cytokines are associated with systemic inflammation in patients with severe periodontal infections. Cytokine 2004;28:29-34.
13. Iacopino AM. Periodontitis and diabetes interrelationships: role of inflammation. Ann Periodontol 2001;6:125-137.
14. Iacopino AM, Cutler CW. Pathophysiological relationships between periodontitis and systemic disease: recent concepts involving serum lipids. J Periodontol 2000;71:1375-1384.
15. Nishimura F, Iwamoto Y, Mineshiba J, Shimizu A, Soga Y, Murayama Y. Periodontal disease and diabetes mellitus: the role of tumor necrosis factor-alpha in a 2-way relationship. J Periodontol 2003;74:97-102.
16. Saito T, Shimazaki Y. Metabolic disorders related to obesity and periodontal disease. Periodontol 2000 2007;43:254-266.
17. Salvi GE, Yalda B, Collins JG et al. Inflammatory mediator response as a potential risk marker for periodontal diseases in insulin-dependent diabetes mellitus patients. J Periodontol 1997;68:127-135.
18. Dullaart RP, de Vries R, Sluiter WJ, Voorbij HA. High plasma C-reactive protein is related to low paraoxonase-I activity independently of high leptin and low adiponectin in Type 2 diabetes mellitus. Clin Endocrinol 2008;70:221-226.
19. Loos BG, Craandijk J, Hoek FJ, Wertheim-van Dillen PM, van der Velden U. Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. J Periodontol 2000;71:1528-1534.
20. Pickup JC, Chusney GD, Thomas SM, Burt D. Plasma interleukin-6, tumour necrosis factor alpha and blood cytokine production in type 2 diabetes. Life Sci 2000;67:291-300.
21. Salzberg TN, Overstreet BT, Rogers JD, Califano JV, Best AM, Schenkein HA. C-reactive protein levels in patients with aggressive periodontitis. J Periodontol 2006;77:933-939.
22. Liu R, Bal HS, Desta T et al. Diabetes enhances periodontal bone loss through enhanced resorption and diminished bone formation. J Dent Res 2006;85:510-514.
23. D'Aiuto F, Parkar M, Andreou G et al. Periodontitis and systemic inflammation: control of the local infection is associated with a reduction in serum inflammatory markers. J Dent Res 2004;83:156-160.
24. Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 2001;286:327-334.
25. Alexandraki K, Piperi C, Kalofoutis C, Singh J, Alaveras A, Kalofoutis A. Inflammatory process in type 2 diabetes: the role of cytokines. Ann N Y Acad Sci 2006;1084:89-117.
26. Altinova AE, Yetkin I, Akbay E, Bukan N, Arslan M. Serum IL-18 levels in patients with type 1 diabetes: relations to metabolic control and microvascular complications. Cytokine 2008;42:217-221.
27. Baker PJ, Dixon M, Evans RT, Dufour L, Johnson E, Roopenian DC. CD4(+) T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice. Infect Immun 1999;67:2804-2809.
28. Chen J, Liu X. The role of interferon gamma in regulation of CD4+ T-cells and its clinical implications. Cell Immunol 2009;254:85-90.
29. Graves DT, Cochran D. The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction. J Periodontol 2003;74:391-401.
30. Irwin CR, Myrillas TT. The role of IL-6 in the pathogenesis of periodontal disease. Oral Dis 1998;4:43-47.
31. Orozco A, Gemmell E, Bickel M, Seymour GJ. Interleukin 18 and periodontal disease. J Dent Res 2007;86:586-593.
32. Paraskevas S, Huizinga JD, Loos BG. A systematic review and meta-analyses on C-reactive protein in relation to periodontitis. J Clin Periodontol 2008;35:277-290.
33. Krauss RM. Lipids and lipoproteins in patients with type 2 diabetes. Diabetes Care 2004;27:1496-1504.
34. Losche W, Karapetow F, Pohl A, Pohl C, Kocher T. Plasma lipid and blood glucose levels in patients with destructive periodontal disease. J Clin Periodontol 2000;27:537-541.
35. Katz J, Flugelman MY, Goldberg A, Heft M. Association between periodontal pockets and elevated cholesterol and low density lipoprotein cholesterol levels. J Periodontol 2002;73:494-500.
36. Rufail ML, Schenkein HA, Koertge TE et al. Atherogenic lipoprotein parameters in patients with aggressive periodontitis. J Periodontal Res 2007;42:495-502.
37. Galic S, Oakhill JS, Steinberg GR. Adipose tissue as an endocrine organ. Mol Cell Endocrinol 2010;316:129-139.
38. Seufert J, Kieffer TJ, Leech CA et al. Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus. J Clin Endocrinol Metab 1999;84:670-676.
39. Welsh P, Murray HM, Buckley BM et al. Leptin predicts diabetes but not cardiovascular disease: results from a large prospective study in an elderly population. Diabetes Care 2009;32:308-310.
40. Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 2005;115:911-919.
41. Saito T, Yamaguchi N, Shimazaki Y et al. Serum levels of resistin and adiponectin in women with periodontitis: the Hisayama study. J Dent Res 2008;87:319-322.
42. Karthikeyan BV, Pradeep AR. Leptin levels in gingival crevicular fluid in periodontal health and disease. J Periodontal Res 2007;42:300-304.
43. Furugen R, Hayashida H, Yamaguchi N et al. The relationship between periodontal condition and serum levels of resistin and adiponectin in elderly Japanese. J Periodontal Res 2008;43:556-562.
44. Karthikeyan BV, Pradeep AR. Gingival crevicular fluid and serum leptin: their relationship to periodontal health and disease. J Clin Periodontol 2007;34:467-472.
45. Yamaguchi N, Kukita T, Li YJ et al. Adiponectin inhibits osteoclast formation stimulated by lipopolysaccharide from Actinobacillus actinomycetemcomitans. FEMS Immunol Med Microbiol 2007;49:28-34.
46. Kamio N, Akifusa S, Yamaguchi N, Nonaka K, Yamashita Y. Anti-inflammatory activity of a globular adiponectin function on RAW 264 cells stimulated by lipopolysaccharide from Aggregatibacter actinomycetemcomitans. FEMS Immunol Med Microbiol 2009;56:241-247.
47. Nishihara R, Sugano N, Takano M et al. The effect of Porphyromonas gingivalis infection on cytokine levels in type 2 diabetic mice. J Periodontal Res 2009;44:305-310.
48. Watanabe K, Petro BJ, Shlimon AE, Unterman TG. Effect of periodontitis on insulin resistance and the onset of type 2 diabetes mellitus in Zucker diabetic fatty rats. J Periodontol 2008;79:1208-1216.
49. Behle JH, Sedaghatfar MH, Demmer RT et al. Heterogeneity of systemic inflammatory responses to periodontal therapy. J Clin Periodontol 2009;36:287-294.
50. Kardesler L, Buduneli N, Cetinkalp S, Kinane DF. Adipokines and inflammatory mediators after initial periodontal treatment in patients with type 2 diabetes and chronic periodontitis. J Periodontol 2010;81:24-33.
51. Matsumoto S, Ogawa H, Soda S et al. Effect of antimicrobial periodontal treatment and maintenance on serum adiponectin in type 2 diabetes mellitus. J Clin Periodontol 2009;36:142-148.
52. Spencer EA, Appleby PN, Davey GK, Key TJ. Validity of self-reported height and weight in 4808 EPIC-Oxford participants. Public Health Nutr 2002;5:561-565.
53. WHO. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 2004;363:157-163.
54. Lang N, Bartold PM, Cullinan M et al. Consensus report: aggressive periodontitis. Ann Periodontol 1999;4:53.
55. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998;15:539-553.
56. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 2003;26(suppl 1):S5-S20.
57. WHO. Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycaemia. Report of A WHO/IDF Consultation. Geneva: WHO, 2006.
58. Peters AL, Davidson MB, Schriger DL, Hasselblad V. A clinical approach for the diagnosis of diabetes mellitus: an analysis using glycosylated hemoglobin levels. Meta-analysis Research Group on the Diagnosis of Diabetes Using Glycated Hemoglobin Levels. JAMA 1996;276:1246-1252.
59. Rohlfing CL, Little RR, Wiedmeyer HM et al. Use of GHb (HbA1c) in screening for undiagnosed diabetes in the U.S. population. Diabetes Care 2000;23:187-191.
60. Engebretson S, Chertog R, Nichols A, Hey-Hadavi J, Celenti R, Grbic J. Plasma levels of tumour necrosis factor-alpha in patients with chronic periodontitis and type 2 diabetes. J Clin Periodontol 2007;34:18-24.
61. Sun XJ, Meng HX, Shi D et al. Elevation of C-reactive protein and interleukin-6 in plasma of patients with aggressive periodontitis. J Periodontal Res 2009;44:311-316.
62. Duarte PM, da Rocha M, Sampaio E et al. Serum levels of cytokines in generalized chronic and aggressive periodontitis subjects before and after non-surgical periodontal therapy: a pilot study. J Periodontol 2010;81:1056-1063.
63. Havemose-Poulsen A, Sorensen LK, Stoltze K, Bendtzen K, Holmstrup P. Cytokine profiles in peripheral blood and whole blood cell cultures associated with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis. J Periodontol 2005;76:2276-2285.
64. Gorska R, Gregorek H, Kowalski J, Laskus-Perendyk A, Syczewska M, Madalinski K. Relationship between clinical parameters and cytokine profiles in inflamed gingival tissue and serum samples from patients with chronic periodontitis. J Clin Periodontol 2003;30:1046-1052.
65. Mengel R, Bacher M, Flores-De-Jacoby L. Interactions between stress, interleukin-1beta, interleukin-6 and cortisol in periodontally diseased patients. J Clin Periodontol 2002;29:1012-1022.
66. Orozco A, Gemmell E, Bickel M, Seymour GJ. Interleukin-1beta, interleukin-12 and interleukin-18 levels in gingival fluid and serum of patients with gingivitis and periodontitis. Oral Microbiol Immunol 2006;21:256-260.
67. Yamazaki K, Honda T, Oda T et al. Effect of periodontal treatment on the C-reactive protein and proinflammatory cytokine levels in Japanese periodontitis patients. J Periodontal Res 2005;40:53-58.
68. Ebersole JL, Cappelli D, Mott G, Kesavalu L, Holt SC, Singer RE. Systemic manifestations of periodontitis in the non-human primate. J Periodontal Res 1999;34:358-362.
69. Rufail ML, Schenkein HA, Barbour SE, Tew JG, van Antwerpen R. Altered lipoprotein subclass distribution and PAF-AH activity in subjects with generalized aggressive periodontitis. J Lipid Res 2005;46:2752-2760.
70. Monteiro AM, Jardini MA, Alves S et al. Cardiovascular disease parameters in periodontitis. J Periodontol 2009;80:378-388.
71. Demmer RT, Papapanou PN. Epidemiologic patterns of chronic and aggressive periodontitis. Periodontol 2000 2010;53:28-44.
72. Mombelli A, Casagni F, Madianos PN. Can presence or absence of periodontal pathogens distinguish between subjects with chronic and aggressive periodontitis? A systematic review J Clin Periodontol 2002;29(suppl 3):10-21.