Antimalarial activity of imidazo[2,1-a]isoindol-5-ol derivatives and related compounds

European Journal of Medicinal Chemistry

Volumn 46, Issue 11, 2011, Pages 5379-5386

  Olmo, Esther Del ^a   Barboza, Bianca ^a   Chiaradia, Louise D ^b   Moreno, Alicia ^c   Carrero Lérida, Juana ^d   González Pacanowska, Dolores ^d   Muñoz, Victoria ^e   López Pérez, José L ^a   Giménez, Alberto ^e   Benito, Agustín ^c   Martínez, Antonio R ^f   Ruiz Pérez, Luis M ^d   San Feliciano, Arturo ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

^d INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^e UNIVERSIDAD MAYOR DE SAN ANDRÉS   (Bolivia)

^f UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Imidazoisoindoles; In vitro assays; In vivo assays; Mouse model; Plasmodium berghei; Plasmodium falciparum; Structure activity relationship; Synthesis

Indexed keywords

11 (2 NAPHTHYLMETHYL) 11H ISOINDOLO[2,1 A]BENZIMIDAZOL 11 OL; 11 (4 METHYLSULFANYLBENZYL) 11H ISOINDOLO[2,1 A]BENZIMIDAZOL 11 OL; 5 (1 NAPHTHYLMETHYL) 2,5 DIHYDRO 3H IMIDAZO[2,1 A]ISOINDOL 5 OL; 5 (1,3 BENZODIOXOL 5 YLMETHYL) 2,5 DIHYDRO 3H IMIDAZO[2,1 A]ISOINDOL 5 OL; 5 (2 CHLOROBENZYL) 2,5 DIHYDRO 3H IMIDAZO[2,1 A]ISOINDOL 5 OL; 5 (2 HYDROXYBENZYL) 2,5 DIHYDRO 3H IMIDAZO[2,1 A]ISINDOL 5 OL; 5 (2 METHOXYBENZYL) 2,5 DIHYDRO 3H IMIDAZO[2,1 A]ISOINDOL 5 OL; 5 (2 NAPHTHYLMETHYL) 2,5 DIHYDRO 3H IMIDAZO[2,1 A]ISOINDOL 5 OL; 5 (2 THIENYLMETHYL) 2,5 DIHYDRO 3H IMIDAZO[2,1 A]ISOINDOL 5 OL; 5 (2,4 DICHLOROBENZYL) 2,5 DIHYDRO 3H IMIDAZO[2,1 A]ISOINDOL 5 OL; 5 (2,4 DIFLUOROBENZYL) 2,5 DIHYDRO 3H IMIDAZO[2,1 A]ISOINDOL 5 OL; 5 (3 CHLORO 4 HYDROXYBENZYL) 2,5 DIHYDRO 3H IMIDAZO[2,1 A]ISOINDOL 5 OL; 5 (3 METHOXYBENZYL) 2,5 DIHYDRO 3H IMIDAZO[2,1 A]ISOINDOL 5 OL; 5 (3 THIENYLMETHYL) 2,5 DIHYDRO 3H IMIDAZO[2,1 A]ISOINDOL 5 OL; 5 (3,4 DICHLOROBENZYL) 2,5 DIHYDRO 3H IMIDAZO[2,1 A]ISOINDOL 5 OL; 5 (3,4 DIMETHOXYBENZYL) 2,5 DIHYDRO 3H IMIDAZO[2,1 A]ISOINDOL 5 OL; 5 (3,4,5 TRIMETHOXYBENZYL) 2,5 DIHYDRO 3H IMIDAZO[2,1 A]ISOINDOL 5 OL; 5 (3,5 DIFLUOROBENZYL) 2,5 DIHYDRO 3H IMIDAZO[2,1 A]ISOINDOL 5 OL; 5 (4 CHLOROBENZYL) 2,5 DIHYDRO 3H MIDAZO[2,1 A]ISOINDOL 5 OL; 5 (4 FLUOROBENZYL) 2,5 DIHYDRO 3H IMIDAZO[2,1 A]ISOINDOL 5 OL; 5 (4 METHOXYBENZYL) 2,5 DIHYDRO 3H IMIDAZO[2,1 A]ISOINDOL 5 OL; 5 (4 METHYLSULFANYLBENZYL) 2,5 DIHYDRO 3H IMIDAZO[2,1 A]ISOINDOL 5 OL; 5 [(1 METHYL 1H INDOL 2 YL)METHYL] 2,5 DIHYDRO 3H IMIDAZO[2,1 A]ISOINDOL 5 OL; 5 BENZYL 2,5 DIHYDRO 3H IMIDAZO[2,1 A]ISOINDOL 5 OL; 7 (8)METHYL 11 (2-NAPHTHYLMETHYL) 11H ISOINDOLO[2,1 A]BENZIMIDAZOL 11 OL; 7(8)METHYL 11 (4 METHYLSULFANYLBENZYL) 11H ISOINDOLO[2,1 A]BENZIMIDAZOL 11 OL; IMIDAZO[2,1 A]ISOINDOL 5 OL DERIVATIVE; IMIDAZOLE; IMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; DRUG EFFICACY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARASITEMIA; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; BENZENE; CELL LINE; IMIDAZOLES; INHIBITORY CONCENTRATION 50; ISOINDOLES; MALE; MICE; PARASITEMIA; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM;

EID: 80054907453     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.08.043     Document Type: Article

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