A novel compound inhibits reconstituted high-density lipoprotein assembly and blocks nascent high-density lipoprotein biogenesis downstream of apolipoprotein AI binding to atp-binding cassette transporter A1-expressing cells

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 31, Issue 11, 2011, Pages 2700-2706

  Lyssenko, Nicholas N ^a,b   Brubaker, Gregory ^a   Smith, Bradley D ^a,c   Smith, Jonathan D ^d  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF NOTRE DAME   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ABCA1; apoAI; nascent HDL; reverse cholesterol transport; rHDL

Indexed keywords

ABC TRANSPORTER A1; APOLIPOPROTEIN A1; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; PHOSPHOLIPID; TRANSFERRIN;

ANIMAL CELL; ARTICLE; BIOGENESIS; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; HYDROGEN BOND; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION;

ANIMALS; APOLIPOPROTEIN A-I; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE; CHOLATES; ETHYLENEDIAMINES; LIPOPROTEINS, HDL; LIPOSOMES; MACROPHAGES; MICE; MODELS, ANIMAL; PHOSPHOLIPID TRANSFER PROTEINS; PROTEIN BINDING; TRANSFERRIN;

EID: 80054895318     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.111.234906     Document Type: Article

References (33)

1. Cuchel M, Rader DJ. Macrophage reverse cholesterol transport: key to the regression of atherosclerosis? Circulation. 2006;113:2548-2555. (Pubitemid 43948034)
2. Yvan-Charvet L, Wang N, Tall AR. Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses. Arterioscler Thromb Vasc Biol. 2010;30:139-143.
3. Hamon Y, Broccardo C, Chambenoit O, Luciani MF, Toti F, Chaslin S, Freyssinet JM, Devaux PF, McNeish J, Marguet D, Chimini G. ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine. Nat Cell Biol. 2000;2:399-406.
4. Nandi S, Ma L, Denis M, Karwatsky J, Li Z, Jiang XC, Zha X. ABCA1-mediated cholesterol efflux generates microparticles in addition to HDL through processes governed by membrane rigidity. J Lipid Res. 2009;50:456-466.
5. Smith JD, Waelde C, Horwitz A, Zheng P. Evaluation of the role of phosphatidylserine translocase activity in ABCA1-mediated lipid efflux. J Biol Chem. 2002;277:17797-17803. (Pubitemid 34967587)
6. Smith JD, Le Goff W, Settle M, Brubaker G, Waelde C, Horwitz A, Oda MN. ABCA1 mediates concurrent cholesterol and phospholipid efflux to apolipoprotein A-I. J Lipid Res. 2004;45:635-644. (Pubitemid 38405669)
7. Jonas A. Reconstitution of high-density lipoproteins. Methods Enzymol. 1986;128:553-582. (Pubitemid 16100916)
8. Vedhachalam C, Duong PT, Nickel M, Nguyen D, Dhanasekaran P, Saito H, Rothblat GH, Lund-Katz S, Phillips MC. Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-I and formation of high density lipoprotein particles. J Biol Chem. 2007;282:25123-25130. (Pubitemid 47347535)
9. Sasaki Y, Shukla R, Smith BD. Facilitated phosphatidylserine flip-flop across vesicle and cell membranes using urea-derived synthetic translocases. Org Biomol Chem. 2004;2:214-219.
10. Lambert TN, Boon JM, Smith BD, Pérez-Payán MN, Davis AP. Facilitated phospholipid flip-flop using synthetic steroid-derived translocases. J Am Chem Soc. 2002;124:5276-5277. (Pubitemid 34506918)
11. Boon JM, Smith BD. Synthetic membrane transporters. Curr Opin Chem Biol. 2002;6:749-756. (Pubitemid 35449333)
12. DiVittorio KM, Hofmann FT, Johnson JR, Abu-Esba L, Smith BD. Facilitated phospholipid translocation in vesicles and nucleated cells using synthetic small molecule scramblases. Bioorg Med Chem. 2009;17:141-148.
13. Boon JM, Lambert TN, Sisson AL, Davis AP, Smith BD. Facilitated phosphatidylserine (PS) flip-flop and thrombin activation using a synthetic PS scramblase. J Am Chem Soc. 2003;125:8195-8201. (Pubitemid 36828582)
14. Fukuda M, Nakano M, Miyazaki M, Tanaka M, Saito H, Kobayashi S, Ueno M, Handa T. Conformational change of apolipoprotein A-I and HDL formation from model membranes under intracellular acidic conditions. J Lipid Res. 2008;49:2419-2426.
15. Macia E, Ehrlich M, Massol R, Boucrot E, Brunner C, Kirchhausen T. Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell. 2006;10: 839-850. (Pubitemid 43779110)
16. Massey JB, Pownall HJ. Cholesterol is a determinant of the structures of discoidal high density lipoproteins formed by the solubilization of phospholipid membranes by apolipoprotein A-I. Biochim Biophys Acta. 2008; 1781:245-253.
17. Jonas A, Mason WR. Interactions of dipalmitoyl-and dimyristoylphosphatidylcholines and their mixtures with apolipoprotein A-I. Biochemistry. 1981;20:3801-3805.
18. Tatulian SA. Ionization and ion binding. In: Cevc G, ed. Phospholipids Handbook. New York, NY: Marcel Dekker; 1993:511-552.
19. Boon JM, Lambert TN, Smith BD, Beatty AM, Ugrinova V, Brown SN. Structure/activity study of tris(2-aminoethyl)amine-derived translocases for phosphatidylcholine. J Org Chem. 2002;67:2168-2174. (Pubitemid 34293000)
20. Wen N, Brooker MH. Urea protonation: Raman and theoretical study. J Phys Chem. 1993;97:8608-8616.
21. Lentz BR. Use of fluorescent probes to monitor molecular order and motions within liposome bilayers. Chem Phys Lipids. 1993;64:99-116. (Pubitemid 23290868)
22. Duong PT, Collins HL, Nickel M, Lund-Katz S, Rothblat GH, Phillips MC. Characterization of nascent HDL particles and microparticles formed by ABCA1-mediated efflux of cellular lipids to apoA-I. J Lipid Res. 2006;47:832-843.
23. Tang C, Vaughan AM, Anantharamaiah GM, Oram JF. Janus kinase 2 modulates the lipid-removing but not protein-stabilizing interactions of amphipathic helices with ABCA1. J Lipid Res. 2006;47:107-114. (Pubitemid 43107454)
24. Nagao K, Zhao Y, Takahashi K, Kimura Y, Ueda K. Sodium taurocholate-dependent lipid efflux by ABCA1: effects of W590S mutation on lipid translocation and apolipoprotein A-I dissociation. J Lipid Res. 2009;50:1165-1172.
25. Oram JF, Lawn RM, Garvin MR, Wade DP. ABCA1 is the cAMPinducible apolipoprotein receptor that mediates cholesterol secretion from macrophages. J Biol Chem. 2000;275:34508-34511.
26. Faulkner LE, Panagotopulos SE, Johnson JD, Woollett LA, Hui DY, Witting SR, Maiorano JN, Davidson WS. An analysis of the role of a retroendocytosis pathway in ABCA1-mediated cholesterol efflux from macrophages. J Lipid Res. 2008;49:1322-1332.
27. Chroni A, Liu T, Fitzgerald ML, Freeman MW, Zannis VI. Cross-linking and lipid efflux properties of apoA-I mutants suggest direct association between apoA-I helices and ABCA1. Biochemistry. 2004;43:2126-2139. (Pubitemid 38233274)
28. Lu R, Arakawa R, Ito-Osumi C, Iwamoto N, Yokoyama S. ApoA-I facilitates ABCA1 recycle/accumulation to cell surface by inhibiting its intracellular degradation and increases HDL generation. Arterioscler Thromb Vasc Biol. 2008;28:1820-1824.
29. Schubert R, Schmidt KH. Structural changes in vesicle membranes and mixed micelles of various lipid compositions after binding of different bile salts. Biochemistry. 1988;27:8787-8794. (Pubitemid 19008195)
30. Vedhachalam C, Ghering AB, Davidson WS, Lund-Katz S, Rothblat GH, Phillips MC. ABCA1-induced cell surface binding sites for ApoA-I. Arterioscler Thromb Vasc Biol. 2007;27:1603-1609. (Pubitemid 46986116)
31. Andrieux K, Forte L, Lesieur S, Paternostre M, Ollivon M, Grabielle-Madelmont C. Solubilisation of dipalmitoylphosphatidylcholine bilayers by sodium taurocholate: a model to study the stability of liposomes in the gastrointestinal tract and their mechanism of interaction with a model bile salt. Eur J Pharm Biopharm. 2009;71:346-355.
32. Dathe M, Schümann M, Wieprecht T, Winkler A, Beyermann M, Krause E, Matsuzaki K, Murase O, Bienert M. Peptide helicity and membrane surface charge modulate the balance of electrostatic and hydrophobic interactions with lipid bilayers and biological membranes. Biochemistry. 1996;35:12612-12622. (Pubitemid 26318059)
33. Drin G, Antonny B. Amphipathic helices and membrane curvature. FEBS Lett. 2010;584:1840-1847.