Dalteparin dose-dependently increases ROTEM ® thrombelastography parameters only at supratherapeutic anti-factor Xa levels: An in vitro study

Clinical and Experimental Pharmacology and Physiology

Volumn 38, Issue 11, 2011, Pages 783-786

  Feuring, Martin ^a   Wehling, Martin ^a   Schultz, Armin ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Dalteparin; Low molecular weight heparin; ROTEM ; Thrombelastography

Indexed keywords

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 8; DALTEPARIN; LOW MOLECULAR WEIGHT HEPARIN;

ANALYZER; ANTICOAGULATION; ARTICLE; BLOOD CLOTTING; BLOOD CLOTTING TIME; CLINICAL TRIAL; CONCENTRATION (PARAMETERS); DEVICE; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MAXIMUM CLOT FIRMNESS; NORMAL HUMAN; THROMBOCYTE FUNCTION; THROMBOELASTOGRAPHY;

ADULT; ANTICOAGULANTS; BLOOD COAGULATION; BLOOD COAGULATION TESTS; BLOOD PLATELETS; DALTEPARIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FACTOR XA; GERMANY; HEPARIN, LOW-MOLECULAR-WEIGHT; HUMANS; MALE; PARTIAL THROMBOPLASTIN TIME; THROMBELASTOGRAPHY;

EID: 80054883842     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2011.05593.x     Document Type: Article

References (17)

1. US Food and Drug Administration. FDA Advisory Committee Briefing Document, Oncologic Drugs Advisory Meeting, September 6, 2006: Dalteparin Sodium (Fragemin) NDA 20-287 S-035. 2006. Available from: (accessed 5 February 2011).
2. Datapharm Communications Limited. Electronic Medicines Compendium (eMC). 2011. Available from: (accessed 5 February 2011).
3. Traverso CI, Caprini JA, Arcelus JI. The normal thromboelastogram and its interpretation. Semin. Thromb. Hemost. 1995; 21: 7-3.
4. Spiel AO, Mayr FB, Firbas C, Ouehenberger P, Jilma B. Validation of rotation thrombelastography in a model of systemic activation of fibrinolysis and coagulation in humans. J. Thromb. Haemost. 2005; 4: 411-6.
5. Tamura N, Kitajima I, Kawamura Y et al. Important regulatory role of activated platelet-derived procoagulant activity in the propagation of thrombi formed under arterial blood flow conditions. Circ. J. 2009; 73: 540-8.
6. Schobersberger W, Mittermayr M, Fries D et al. Changes in blood coagulation of arm and leg veins during a simulated long-haul flight. Thromb. Res. 2007; 119: 293-300.
7. Luddington RJ. Thrombelastography/thromboelastometry. Clin. Lab. Haematol. 2005; 27: 81-90.
8. Artang R, Frandsen NJ, Nielsen JD. Application of basic and composite thrombelastography parameters in monitoring of the antithrombotic effect of the low molecular weight heparin dalteparin: An in vivo study. Thromb. J. 2009; 7: 14.
9. May JA, Fox S, Glenn J, Craxford S, Heptinstall S. Platelet function reduces significantly during the morning. Platelets 2008; 19: 556-8.
10. Feuring M, Wehling M, Ruf A, Schultz A. Circadian variation of platelet function measured with the PFA-100. Platelets 2009; 20: 466-70.
11. Niemi TT, Kuitunen AH. Artificial colloids impair haemostasis. An in vitro study using thromboelastometry coagulation analysis. Acta Anaesthesiol. Scand. 2005; 49: 373-8.
12. Fries D, Innerhofer P, Reif C et al. The effect of fibrinogen substitution on reversal of dilutional coagulopathy: An in vitro model. Anesth. Analg. 2006; 102: 347-1.
13. Levrat A, Gros A, Rugeri L et al. Evaluation of rotation thrombelastography for the diagnosis of hyperfibrinolysis in trauma patients. Br. J. Anaesth. 2008; 100: 792-7.
14. Daudel F, Kessler U, Folly H, Lienert JS, Takala J, Jakob SM. Thromboelastometry for the assessment of coagulation abnormalities in early and established adult sepsis: A prospective cohort study. Crit. Care 2009; 13: R42.
15. Huissoud C, Carrabin N, Benchaib M et al. Coagulation assessment by rotation thrombelastometry in normal pregnancy. Thromb. Haemost. 2009; 101: 755-1.
16. Huissoud C, Carrabin N, Audibert F et al. Bedside assessment of fibrinogen level in postpartum haemorrhage by thrombelastometry. BJOG 2009; 116: 1097-2.
17. Akay OM, Ustuner Z, Canturk Z, Mutlu FS, Gulbas Z. Laboratory investigation of hypercoagulability in cancer patients using rotation thrombelastography. Med. Oncol. 2009; 26: 358-4.