Effects of nortriptyline on QT prolongation: A safety pharmacology study

Human and Experimental Toxicology

Volumn 30, Issue 10, 2011, Pages 1649-1656

  Jeon, Seol Hee ^a   Jaekal, Jun ^a   Lee, Seung Ho ^b   Choi, Bok Hee ^b   Kim, Ki Suk ^c   Jeong, Ho Sang ^a   Han, Soon Young ^a   Kim, Eun Jung ^a  

^a National Institute of Food and Drug Safety Evaluation   (South Korea)

^b Chonbuk National University Medical School   (South Korea)

^c Korea Institute of Toxicology   (South Korea)

Author keywords

nortriptyline; QT prolongation; safety pharmacology

Indexed keywords

NORTRIPTYLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG EFFECT; DRUG SAFETY; DRUG STRUCTURE; ELECTROCARDIOGRAM; ELECTROPHYSIOLOGY; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART MUSCLE POTENTIAL; HEART RATE; HEART REPOLARIZATION; HEART VENTRICLE PRESSURE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LOW DRUG DOSE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PHARMACOLOGY; PRIORITY JOURNAL; PURKINJE FIBER; QT INTERVAL; QT PROLONGATION; SYSTOLIC BLOOD PRESSURE;

ACTION POTENTIALS; ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BLOOD PRESSURE; DOGS; ELECTROCARDIOGRAPHY; ETHER-A-GO-GO POTASSIUM CHANNELS; HEART RATE; HEK293 CELLS; HUMANS; LONG QT SYNDROME; MALE; NORTRIPTYLINE; PURKINJE FIBERS; RABBITS;

CANIS FAMILIARIS; ORYCTOLAGUS CUNICULUS;

EID: 80054866175     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327110396528     Document Type: Article

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